A new study published in Nature, conducted by an alliance between industry and academia involving the University of Liverpool, highlights a new approach to targeting key cancer-linked proteins, thought to be 'undruggable'.
A study by UC San Diego biologists uncovered a new mechanism linking a human gene's function to chronic inflammation. Through large-scale genomic analyses, the researchers discovered that 'mutant p53' amplifies the impact of inflammation, leading to increases in the invasive behavior of cancer. Thus, rather than fighting tumor growth, mutant forms of p53 appear to be tapping into the body's immune response system to fuel pro-inflammatory responses that increase cancer growth.
Two UA materials science and engineering researchers have experimentally verified the electrochemical processes that control charge transfer rate from an organic polymer to a biomarker molecule. Their findings, reported in Nature Communications, may enhance selectivity for biomarkers in bioelectronic devices.
UAB researchers have solved the last unknown protein structure of HIV-1, the retrovirus that can cause AIDS. Knowledge of this structure, called the cytoplasmic tail of gp41 protein, will further explain how the virus infects human cells and how progeny viruses are assembled and released from infected cells. The cytoplasmic tail appears to play a key role in virus assembly to help incorporate the envelope spike structures into the surface of viral particles.
Breast cancer cells recycle ammonia, a waste byproduct of cell metabolism, and use it as a source of nitrogen to fuel tumor growth, report scientists from Harvard Medical School. The insights shed light on the biological role of ammonia in cancer and may inform the design of new therapeutic strategies to slow tumor growth.
Using a revolutionary live-cell microscopy technique, an international team of scientist has observed for the first time individual receptors for hormones and widely used drugs at work in intact cells.
New findings by a Harvard Medical School team suggest that palbociclib, a drug that is FDA-approved to treat advanced breast cancer, may be able to overcome vemurafenib resistance in PTC.
In a paper published in Nature Communications, Christoph Adami, professor of microbiology and molecular genetics, and graduate student Thomas LaBar have provided a look at how certain species survive by evolving a greater ability to weed out harmful mutations -- a new concept called 'drift robustness.'
Could studying molecular biology ever be as fun as watching a Star Wars movie? Two scientists from the Wyss Institute at Harvard University decided to create their own science film to entertain viewers, and ended up making new scientific discoveries in the process. The researchers-turned-filmmakers used a novel combination of computer animation and simulation softwares to create a scientific model that is accurate down to the atomic scale, and hope that their success inspires more scientists to approach their work like artists.
A Northwestern University research team has discovered how scalding heat and tissue injury activate an ancient 'pain' receptor in simple animals. The findings, from a study of flatworms, could lead to new strategies for analgesic drug design for the treatment of humans. That planarian flatworms use the same molecular receptor as flies, mice and humans to detect potentially damaging or noxious stimuli from the environment shows a remarkable level of evolutionary conservation, the researchers say.