A TGen-led team has identified how DNA methylation is associated with a condition known as non-alcoholic fatty liver disease (NAFLD), which can lead to liver cirrhosis and death, and is one of the leading indicators for liver transplants. In one of the most exacting studies of its kind, TGen scientists found evidence that DNA methylation has a role in the initiation of NAFLD-related fibrosis, according to a study published in the journal Clinical Epigenetics.
A study detected in tumoral tissue hundreds of RNAs that do not encode proteins but appear to regulate effects of androgens and androgen receptors on gene expression in tumors. By investigating the connection between the presençe of these molecules and tumor aggressiveness, the research paves the way for new scientific approaches focusing on the transcription process of noncoding RNA.
Research led by Suresh Alahari, PhD, Professor of Biochemistry and Molecular Biology at LSU Health New Orleans School of Medicine, has shown for the first time that a tiny piece of RNA deregulates energy metabolism, an emerging hallmark of cancer. The finding identifies a new target for therapeutic intervention in breast cancer.
Memorization test and non linear EEG analysis could be helpful in identifying subjects at high risk of dementia at the very early stages of cognitive impairment.
Researchers from the University of Liverpool have identified a new compound that protects against neurodegeneration in nematode worms. The discovery may enable novel treatments for human neurodegenerative diseases to be developed in the future.
New study calls for human-based tools to unravel the pathogenesis of non-alcoholic steatohepatitis (NASH). The contribution of in silico, in vitro and pathways-based systems biology approaches to unraveling the pathogenesis of this disease are described, and how this human-relevant research can be used for anti-NASH drug development.
A new Osaka-centered study identified the mechanisms of high-fat diet (HFD)-induced prostate cancer progression. They observed in a mouse model that HFD accelerated tumor growth and increased the myeloid-derived suppressor cells fraction and M2/M1 macrophage ratio. Additionally, the anti-inflammatory drug celecoxib suppressed tumor growth. Their results suggest that HFD-induced prostate cancer growth via cytokine IL6 signaling could also exist in obese humans, and celecoxib may have clinical benefits for obese patients with prostate cancer.
A new study by researchers at Okinawa Institute of Science and Technology Graduate University (OIST), provides evidence towards selection in mtDNA due to variations in temperature.
In a new study, a team led by University of Utah biologists has discovered that different versions of a single gene, called NDP (Norrie Disease Protein), have unexpected links between color patterns in pigeons, and vision defects in humans. These gene variations were likely bred into pigeons by humans from a different pigeon species and are now evolutionarily advantageous in wild populations of feral pigeons living in urban environments.
Studying the photochemistry has shown that ultraviolet radiation can set off harmful chemical reactions in the human body and, alternatively, can provide 'photo-protection' by dispersing extra energy. To better understand the dynamics of these photochemical processes, a group of scientists irradiated the RNA base uracil with ultraviolet light and documented its behavior on a picosecond timescale. They discuss their work this week in The Journal of Chemical Physics.