A team led by Van Andel Research Institute (VARI) scientists has revealed for the first time the atomic-level structure of TRPM2, a protein that may be a promising drug target for conditions such as Alzheimer's disease and bipolar disorder.
Researchers have eliminated caged mosquitoes using 'gene drive' technology to spread a genetic modification that blocks female reproduction.
New paper calls for the use of advances human-relevant methods to enable understanding of the initiation and progression of Parkinson's disease.
Scientists at Sanford Burnham Prebys Medical Discovery Institute (SBP) have developed new single-cell approaches wedded to machine learning that allow detection of CNVs below one million base pairs. This has revealed thousands of previously unknown DNA changes arising during prenatal life in the developing mouse brain. The researchers also identified when these changes peaked: evidence that potential regulatory mechanisms -- which remain unknown -- are involved. The study published today in PNAS.
In a paper published Sept. 24 in the journal Nature Plants, an international team of researchers has discovered that the gene FT -- the primary driver of the transition to flowering in plants each spring -- does something unexpected in Arabidopsis thaliana plants grown in natural environments, with implications for the artificial growing conditions scientists commonly used in the lab.
Researchers at University of Tsukuba showed that mutation of a single amino acid in the SIK3 protein caused mice to exhibit more non-REM sleep and increased 'sleep need,' including when awake, reflected in particular patterns of brainwave activity. The findings could help research on human sleep disorders given the similarity of this protein to that in humans.
Researchers have discovered that the protein ASTN2 shuttles receptors away from the surface of neurons, a process that facilitates efficient brain activity.
Fast-breeding zebrafish, combined with fluorescent tagging, could be a powerful way to find new cancer drugs. This study tested >3,800 drugs in high-throughput fashion and found that retinoic acid, best known as an acne treatment, may be effective for adenoid cystic carcinoma. A clinical trial is now being planned at the Dana-Farber Cancer Institute.
Imagine your liver being just a big puddle. Some organelles in your cells are exactly that including prominent ones like the nucleolus. Now a synthetic organelle engineered in a lab at Georgia Tech shows how such puddle organs can carry out complex life-sustaining reaction chains.
Using a bioinformatics approach, University of California San Diego School of Medicine researchers found that CD4+ T cell's binding partner, a molecule called MHC-II, may have even more influence on emerging tumors than MHC-I, the better known partner of CD8+ T cells. The finding, published September 20 in Cell, may help researchers improve cancer immunotherapies and predict which patients will respond best.