Salk Institute scientists studying the relationship of telomeres to cancer made a surprising discovery: a cellular recycling process called autophagy -- generally thought of as a survival mechanism -- actually promotes the death of cells, thereby preventing cancer initiation.
Scientists at USC Michelson Center and Japan's Nagoya University find and test a promising drug that stops cancer by interfering with the cancer cells' metabolism and other circadian-related functions.
For children--whose tiny bodies are still growing--chemotherapy and radiation treatments can cause lifelong damage. Now, scientists at Sanford Burnham Prebys Medical Discovery Institute (SBP) have reported that a targeted therapy that blocks a protein called LSD1 was able to shrink tumors in mice with a form of pediatric brain cancer known as medulloblastoma. LSD1 inhibitors are currently under evaluation in clinical trials for other cancers. The study was published in Nature Communications.
Normal gut bacteria are instrumental in inducing an immune response in the presence of invading pathogens. However, exactly how commensal bacteria cause CX3CR1+ macrophages in the intestine to protrude their tentacle-like dendrites to capture antigens, triggering the immune response, was unclear. Now, an Osaka University-led research team has shown that common bacterial metabolites pyruvate and lactate interact with the GPR31 receptor on CX3CR1+ cells, enhancing the immune response and protecting against gut pathogens.
Using multiple genomic sequencing tests, TGen identified a specific non-polio enterovirus -- EV-D68 -- among at least four children, according to a study published today in the scientific journal mBio. The finding is significant because AFM cases are continuing to increase and there has been no official recognition that this disease is being caused by EV-D68, which limits the research community's ability to develop preventative measures, such as new vaccines.
An approved drug that blocks an integrated stress response shows promise in preliminary tests against ALS and frontotemporal dementia.
Advanced technologies that read long strings of DNA can produce flawed data that could affect genetic studies, research from the University of Edinburgh's Roslin Institute suggests.
Exercise can protect both muscle and nerves from damage caused by the restoration of blood flow after injury or surgery, new research from the University of Virginia School of Medicine shows.
A small change in the genetic makeup of the South African Cape bee turns the socially organised animal into a fighting parasite. This change ensures that infertile worker bees begin to lay their own eggs and fight other colonies. In the current issue of the journal 'Molecular Biology and Evolution', an international research team led by Martin Luther University Halle-Wittenberg (MLU) outlines for the first time the genetic basis for this rare phenomenon.
Using a tool first used for strep throat in horses, Houston Methodist researchers unveiled the secret life of flesh-eating bacteria, learning how it causes severe disease while living deep within muscle. The team focused on necrotizing myositis. The study appears Jan. 22 in the Journal of Clinical Investigation. Corresponding author James M. Musser says his team now has an in-depth understanding of the precise genes group A streptococcus uses to cause this deadly infection.