Although many organisms capture and respond to sunlight, enzymes - proteins that catalyze biochemical reactions - are rarely driven by light. A new study captures the full cycle of complex structural changes in an enzyme called FAP as it transforms a fatty acid into alkanes or alkenes.
Research has identified critical factors that enable dangerous bacteria to spread disease by surviving on surfaces in hospitals and kitchens.
Genome wide analyses have revealed that MSEI, a gene linked with anemia is also associated with insomnia. The correlation between the two conditions, however, remains largely unexplored in adults. Thus, in a cross-sectional study, researchers assessed the relation between anemia and insomnia in a large Chinese cohort. Their findings, published in Chinese Medical Journal, suggest that anemia increases the risk of insomnia. Further studies can help elucidate the underlying molecular and physiological associations.
Researchers have found that a natural molecule can effectively block the binding of a subset of human antibodies to SARS-CoV-2. The discovery may help explain why some COVID-19 patients can become severely ill despite having high levels of antibodies against the virus.
Researchers led by Professors Ivan Berg (University of Münster) and Wolfgang Eisenreich (Technical University of Munich) have new insights into the citric acid cycle: Certain bacteria can use this central metabolic pathway "backwards", but to do so they must have very high concentrations of the enzyme citrate synthase and of carbon dioxide. This pathway may be a relic from the early development of life.
The conversion of light into chemical energy by plants and photosynthetic microorganisms is one of the most important processes in nature, removing climate-damaging CO2 from the atmosphere. Protein complexes, so-called photosystems, play the key role in this process. An international research team shed light for the first time on the structure and function of a transition state in the synthesis of photosystem II.
A research group led by Prof. Hiroyasu Nakano of Department of Biochemistry, Toho University Faculty of Medicine, found that interleukin 11 (IL-11)-positive cells rapidly appear in the colons of mice with colitis and colitis-associated colorectal cancers. In RNA-seq analysis of the gene expression profiles, they found that high expression of enriched genes in IL-11-positive fibroblasts correlated with short duration of disease-free survival in human colorectal cancer patients.
Scientists have shown that the biological molecule PD-L1 is a potential target for the treatment of metastasized oral malignant melanoma in dogs.
A mitochondrial peptide called MOCCI has a surprising sidekick, and they work together to regulate inflammation and immunity, Singapore researchers reveal.
Optimizing manufacturing of rare precursors to drugs has implications in making medications more globally accessible, affordable Microbial production of drug precursors makes product cycle more sustainable Eliminating need for yew trees that take 80 years to grow makes development of taxol, an anti-cancer drug ingredient, possible for more companies