When cells become stressed, they activate specific response patterns. Würzburg researchers have identified new details of these responses, which can help to get a better understanding of neurodegenerative diseases.
Some cancers express unusually high levels of a neural calcium channel known as the 'wasabi receptor,' which plays a role in detecting pain, cold and other sensations. New research finds cancer cells co-opt this neural channel to increase their tolerance against toxic oxidative stress. Blocking the activity of this channel in mice curbs tumor growth and makes cancer cells more sensitive to chemotherapy.
p38 blockage has been shown to increase the death of tumor cells, thus causing tumors to shrink. The combination of p38 inhibitors with chemotherapeutic drugs (taxanes) strengthens, accelerates or prolongs the antitumor effect in patient-derived tumors grown in mice.
Researchers at the University of Michigan Rogel Cancer Center have discovered that tumor cells reprogram metabolic pathways to gain control over a type of immune cell that allows cancer growth.
Scientists have found a connection between bacteria in the gut and antitumor immune responses in the liver. Bacteria found in the gut of mice affect the liver's antitumor immune function. The findings have implications for understanding the mechanisms that lead to liver cancer and for therapeutic approaches to treat them.
Antimicrobial resistance (AMR) is a major medical problem worldwide, impacting both human health and economic well-being. A new strategy for fighting bacteria has now been reported in the latest online issue of Nature by a research group headed by Professor Ivan Dikic at the Goethe University Frankfurt. The scientists revealed the molecular action mechanism of a Legionella toxin and developed a first inhibitor.
Antimicrobial resistance is on the rise worldwide. This is becoming a problem for infectious diseases like tuberculosis as there are only a few active substances available to combat such diseases. Pharmacists at Martin Luther University Halle-Wittenberg (MLU) have now found a way to increase the efficacy of a common tuberculosis agent while, at the same time, reducing resistance to it. The research group presents its latest developments in the international journal Molecules.
We know that hundreds of genes contribute to a wave of activity linked to cell division, but to generate that wave new research shows that cells must first grow large enough to produce four key proteins in adequate amounts, according to research published in Cell Systems.
For the first time, scientists have shown that a small cluster of cells in the human embryo dictates the fate of other embryonic cells. The discovery of this developmental 'organizer' could advance research into 'any human diseases, and it suggests we have more in common with birds than meets the eye.
This study provides a blueprint of how fruit flies can be used as a rapid screening tool to identify potentially pathogenic human genes.