Gut bacteria at a young age can contribute to multiple sclerosis disease onset and progression.
Scientists at Newcastle University, UK have developed a revolutionary technique to allow the continuous production and collection of cells.
Biologists at Berkeley Lab and UC Berkeley used cryo-EM to resolve the structure of a ring of proteins used by the immune system to summon support when under attack, providing new insight into potential strategies for protection from pathogens. The researchers captured the high-resolution image of a protein ring, called an inflammasome, as it was bound to flagellin, a protein from the whiplike tail used by bacteria to propel themselves forward.
Scientists have identified a set of biomarkers that indicate which patients infected with the Ebola virus are most at risk of dying from the disease. The results come from one of the most in-depth studies ever of blood samples from patients with Ebola. Researchers found 11 biomarkers that distinguish fatal infections from non-fatal ones and two that, when screened for early upon symptom onset, accurately predict which patients are likely to die.
A leaf-eating beetle has evolved a symbiotic relationship that allows the insect to break down pectin. The journal Cell published the findings on the novel function of the bacterium, which has a surprisingly tiny genome -- much smaller than previous reports on the minimum size required for an organism not subsisting within a host cell.
Researchers have found that diffusion plays an unexpected role in cell differentiation during the early stages of development in the embryos of Drosophila, or fruit flies. Instead of spreading a molecular signal out, it was found that diffusion, facilitated through a carrier molecule, actually concentrates the signal in one place.
Multidrug resistance of microbes poses a serious global threat to human health. Resistant strains of Klebsiella pneumoniae significantly reduce therapeutic options for the treatment of potentially fatal pneumonia or sepsis. Pavel Kovarik and his team now report new insights into how immune cells communicate at the site of infection and join forces in the fight against Klebsiella infections. Their results might be used for the development of alternatives to ineffective anti-microbial drugs.
New research could boost the development of a more potent vaccine against the global killer.
Pam Silver's research team reports in Molecular Cell two new types of kill switches that address these challenges. The new kill switches are self-sufficient and highly stable in bacterial populations that evolve, and they last over many generations. They can ensure that only bacteria with intact synthetic gene circuits survive, or confine bacteria to a target environment at 37°C (body temperature) while inducing them to die at lower temperatures, as demonstrated during bacterial exit from a mouse intestinal tract.
In a comprehensive and complex molecular study of blood samples from Ebola patients in Sierra Leone, published today (Nov. 16, 2017) in Cell Host and Microbe, a scientific team led by the University of Wisconsin-Madison has identified signatures of Ebola virus disease that may aid in future treatment efforts.