Scientists who highlighted the bug-busting properties of bacteria in Northern Irish soil have made another exciting discovery in the quest to discover new antibiotics.
A new computational technique that uses heat map data to reverse engineer highly detailed models of chromosomes and researchers have uncovered new information about the close spatial relationships that chromatin folding creates between genes.
The intestines and their bacteria are sometimes called our 'second brain', but studying these bacteria in their natural environment is difficult. Now researchers from the University of Copenhagen have developed a method that uses artificial intelligence to map intestinal bacteria using faeces. The researchers thus hope to gain more knowledge of the role played by these bacteria in various diseases.
Researchers have developed a highly sensitive technique to quantitatively evaluate the extent of cytoskeleton bundling from microscopic images. Until now, analysis of cytoskeleton organization was typically made by manually checking microscopic images. The new method uses microscopic image analysis techniques to automatically measure the cytoskeleton organization. The researchers expect it to dramatically improve our understanding of various cellular phenomena related to cytoskeletal bundling.
DNA from various oral bacterial pathogens has been found in tumors from esophageal cancer patients. Researchers led by Tokyo Medical and Dental University (TMDU) examined bacterial pathogens in plaque and saliva from esophageal cancer patients, determining that a prevalence of three species in particular, along with alcohol consumption, is associated with a high risk of esophageal cancer. Screening of oral pathogens could therefore be used for early disease detection.
Researchers from the University of Tsukuba identified a novel mechanism by which bacteria form membrane vesicles, which bacteria employ to communicate with each other or to defend themselves against antibiotics. By studying mycolic acid-containing bacteria (MCB), which also includes tuberculosis-causing bacteria, the researchers demonstrated that environmental stimuli dictate the route by which the MCB form membrane vesicles. Further, their observations were consistent among various MCB. This study has implications for vaccine development as well as novel therapies.
The descendants of regular wild-type bacteria can evolve to survive for a long time on metallic copper surfaces that would usually kill them within a few minutes. An international research team led by Martin Luther University Halle-Wittenberg (MLU) and the Bundeswehr Institute of Microbiology was able to produce these tiny survivalists in the lab and has been able to study them more closely. The team reports on its findings in Applied and Environmental Microbiology.
A new paper describes how researchers at MBARI, the University of Hawai'i at Mānoa (UH Mānoa), and Woods Hole Oceanographic Institution, enabled a trio of self-driving robots to locate, follow, and sample a layer of oceanic microbes as they drifted in an open-ocean eddy north of the Hawaiian islands.
Researchers have found a simple way to eliminate almost all sequencing errors produced by a widely used portable DNA sequencer (Oxford Nanopore Technologies' MinION device).
Scientists have used gene-editing advances to achieve a tenfold increase in the production of super-bug targeting formicamycin antibiotics.