Researchers explain a cell differentiation mechanism in Nature Genetics.
Researchers at The Scripps Research Institute recently published a study in the journal Cell Death and Differentiation identifying factors crucial to mesenchymal stem cell differentiation, providing insight into how these cells should be studied for clinical purposes.
A team led by the Department of Energy's Oak Ridge National Laboratory has uncovered how certain soil microbes cope in a phosphorus-poor environment to survive in a tropical ecosystem. Their novel approach could be applied in other ecosystems to study various nutrient limitations and inform agriculture and terrestrial biosphere modeling.
A study headed by ICREA researcher Roger Gomis at the Institute for Research in Biomedicine (IRB Barcelona) has identified the genes involved in the latent asymptomatic state of breast cancer metastases. The work sheds light on the molecular basis underlying how the expression of certain genes facilitates the spread of metastatic lesions.
As obesity continues to rise in the US, non-alcoholic fatty liver disease (NAFLD) has become a major public health issue, increasingly leading to cancer and liver transplants.
Localized gene delivery to diseased joints to achieve sustained drug production at the site of osteoarthritis or rheumatoid arthritis is gaining momentum, with clinical trials underway in the US and the first arthritis gene therapy recently approved in Korea.
In the analysis of the human genome, one question researchers have so far left unanswered is how to differentiate the variants of a gene inherited from the mother and father. Such information would increase the likelihood of treating certain diseases successfully. The so-called third generation of sequencing technologies is now making this possible.
UZH plant researchers have tested newly developed wheat lines with improved resistance in field trials. They have demonstrated that a combination of two variations of a resistance gene provides wheat with better protection against the fungal disease.
Growing in crocodile infested billabongs in the remote North of the country, Australia's wild rice has been confirmed as the most closely related to the ancient ancestor of all rices. The unique genetics of the Australian rice may help breed disease resistance and climate adaptation into rice modern production species.
A University of Queensland discovery has deepened our understanding of the genetic mutations that arise in different tissues, and how these are inherited. Researchers from UQ's Queensland Brain Institute, led by Dr. Steven Zuryn, found the rates of genetic mutations in mitochondrial DNA vary across differing tissue types, with the highest rate occurring in reproductive cells.