The biodistribution of adeno-associated virus (AAV) gene transfer vectors can be measured in nonhuman primates using a new method. The method quantifies whole-body and organ-specific AAV capsids from 1 to 72 hours after administration
To date, paralysis resulting from spinal cord damage has been irreparable. With a new therapeutic approach, scientists from the Department for Cell Physiology at Ruhr-Universität Bochum (RUB) headed by Professor Dietmar Fischer have succeeded for the first time in getting paralyzed mice to walk again. The keys to this are the protein hyper-interleukin-6, which stimulates nerve cells to regenerate, and the way how it is supplied to the animals.
Having genitals of a certain shape and size gives male flies a major reproductive advantage, new research shows.
Researchers at RIKEN, Japan successfully created a larger strain of zooplankton by creating mutations with a heavy ion beam, which contributes to improving the survival rate and growth of juvenile fish in aquaculture.
Some organisms evolve an internal switch that can remain hidden for generations until stress flicks it on.
Just like humans trying to stick to New Year's resolutions, guppies have varying levels of self-control, a new study shows.
Using data from RNA-folding experiments, the researchers generated the first-ever data-driven movies of how RNA folds as it is made by cellular machinery. By watching their videos of this folding occur, the researchers discovered that RNA often folds in surprising, perhaps unintuitive ways, such as tying itself into knots.
Molybdenum cofactor (Moco) is a compound that is little known but is essential for life. Children born without the ability to synthesize Moco die young. It has not been possible to create Moco supplements because the compound is so unstable. Studies in the nematode Caenorhabditis elegans suggest that by combining, Moco with certain proteins, it becomes stable and can repair deficiency.
Scientists have found a new species of fleshy verdigris lichen, thanks to DNA analysis of museum specimens. Misidentified by its original collectors, the lichen is only known from 32 specimens collected in North and Central Florida scrubland between 1885 and 1985. Now the hunt is on to find it in the wild -- if it still exists.
A new computational technique that uses heat map data to reverse engineer highly detailed models of chromosomes and researchers have uncovered new information about the close spatial relationships that chromatin folding creates between genes.