A bone cancer known as osteosarcoma is genetically similar in dogs and human children, according to the results of a study published today by Tufts University and the Translational Genomics Research Institute (TGen), an affiliate of City of Hope. The findings could help break the logjam in the treatment of this deadly disease, which hasn't seen a significant medical breakthrough in nearly three decades.
3q29 deletion syndrome is a strong risk factor for both schizophrenia and autism spectrum disorder. People with the rare condition have a distinct neuropsychiatric profile, researchers found.
A research team led by Leonor Saúde, Principal Investigator at Instituto de Medicina Molecular, in partnership with the company Technophage, SA, has designed a simple and efficient platform that uses zebrafish to discover and identify new drugs to treat spinal cord lesions. This study, published today in Scientific Reports, is the proof-of-concept for the use of this zebrafish platform that, combined with drug repurposing, has the potential to accelerate the translation period from the discovery to the clinics.
Researchers at NHGRI have performed the largest GWAS study on type 2 diabetes in the sub-Saharan African populations, revealing an association between the disease and previously unlinked ZRANB3 gene. By using animal models, their results show that dysfunction of the ZRANB3 gene has major repercussions on insulin production. This link may hold key answers to the treatment of type 2 diabetes in all populations.
Researchers have found that a gene known as AEBP1 may play a central role in the development, severity and potential treatment of liver disease, according to a study by Temple University, the Geisinger Obesity Institute and the Translational Genomics Research Institute (TGen), an affiliate of City of Hope. One of the study's major findings is that AEBP1 regulates the expression of a network of at least nine genes related to fibrosis: AKR1B10, CCDC80, DPT, EFEMP1, ITGBL1, LAMC3, MOXD1, SPP1, and STMN2.
Neuroscientists from the Salk Institute and UC San Diego have discovered that at least six types of mammals -- from mice to cats -- distinguish odors in roughly the same way, using circuitry in the brain that's evolutionarily preserved across species.
An international team of researchers have identified and described two new frog species and have named one of them after a University of Central Florida professor.
KAIST researchers have identified somatic mutations in the brain that could contribute to the development of Alzheimer's disease (AD).
An international Research Team led by Dr. Jeong Yoon-ha at Korea Brain Research Institute has published the results of its research in 'Autophagy'. Expected to develop the treatment for neurodegenerative disease utilizing TDP-43 protein.
Low doses of radiation equivalent to three CT scans, which are considered safe, give cancer-capable cells a competitive advantage over normal cells. Researchers studied the effects of low doses of radiation in mice and found it increases the number of cells with mutations in p53, a well-known genetic change associated with cancer. However, giving the mice an antioxidant before radiation promoted the growth of healthy cells, which outcompeted and replaced the p53 mutant cells.