People infected with HIV are twice as likely to suffer from heart disease, research has found. Analysis of global figures reveals that HIV-associated cardiovascular disease has more than tripled in the past 20 years as more people are living longer with the virus. The greatest impact is in sub-Saharan Africa and Asia Pacific regions, with Swaziland, Botswana and Lesotho particularly affected.
New study calls for human-based tools to unravel the pathogenesis of non-alcoholic steatohepatitis (NASH). The contribution of in silico, in vitro and pathways-based systems biology approaches to unraveling the pathogenesis of this disease are described, and how this human-relevant research can be used for anti-NASH drug development.
Voluntary medical male circumcision could impact Zimbabwe's HIV epidemic in the coming years, and this investment may save costs in the longer term. These findings were reported by Jessica McGillen of Imperial College London and colleagues on July 18 in the open-access journal PLOS ONE.
Men may recover more quickly from influenza infections because they produce more of a key lung-healing protein, a study from scientists at Johns Hopkins Bloomberg School of Public Health suggests.
Recent Ebola virus disease (EVD) outbreaks highlight the need for licensed treatments. ZMapp, an experimental therapy, has shown promise in a clinical trial, but targets only one of five known species of Ebola virus. Now NIAID-supported scientists have discovered powerful, broadly neutralizing antibodies (bNAbs) in the blood of EVD survivors. In animal studies, two of these antibodies provided substantial protection against disease caused by the three species known to cause fatal human illness.
The estimates for global tuberculosis deaths by the World Health Organisation (WHO) and the Institute for Health Metrics and Evaluation (IHME) differ considerably for a dozen countries, according to a study led by ISGlobal. The results highlight the need to improve the modeling approaches in these countries in order to understand the true burden of the disease and design adequate health policies.
Death due to cardiovascular disease is on the rise in India, causing more than one quarter of all deaths in the country in 2015 and affecting rural populations and young adults the most, suggests a new study.
A Yale-led team of researchers have created a vaccine that protects against malaria infection in mouse models, paving the way for the development of a human vaccine that works by targeting the specific protein that parasites use to evade the immune system. The study was published by Nature Communications.
Experts are drawing on lessons learned from the early days of the HIV epidemic to address the current opioid epidemic. As a result of widespread opioid abuse, new epidemics of hepatitis C virus (HCV) and HIV infection have arisen and hospitalizations for related infections have increased. An expert panel convened by the National Academies of Sciences, Engineering, and Medicine (NASEM) recommends five crucial steps for clinicians treating patients affected by opioid addiction and these intersecting infections.
A new scientific study finds 93 people live in remote areas with venomous snakes and, if bitten, face a greater likelihood of dying than those in urban settings because of poor access to anti-venom medications.