Researchers have developed a quality control method to evaluate the pharmacological activity and potential effectiveness of different preparations of the therapeutic agent methyl-β-cyclodextrin (MβCD).
Treatment of heart attack patients depends on their history of cancer, according to research published today in European Heart Journal: Acute Cardiovascular Care. The study in more than 35,000 heart attack patients found they were less likely to receive recommended drugs and interventions, and more likely to die in hospital if they had cancer than if they did not.
Data released today from the US President's Emergency Plan for AIDS Relief (PEPFAR) show that the HIV epidemic is coming under control in Lesotho. These results add to prior PEPFAR-supported Population-based HIV Impact Assessments (PHIAs) announced in the last nine months for Malawi, Swaziland, Zambia, and Zimbabwe. Together, these data demonstrate impressive progress toward controlling the HIV epidemics in the five countries.
India has avoided about 1 million deaths of children under age five since 2005, driven by significant reductions in mortality from pneumonia, diarrhea, tetanus and measles, according to new research published today.
Scientists at the University of Southampton have made a significant discovery in efforts to develop a vaccine against Zika, dengue and Hepatitis C viruses that affect millions of people around the world.
An international research team has shown for the first time that carbohydrates on the surface of malaria parasites play a critical role in malaria's ability to infect mosquito and human hosts. The discovery also suggests steps that may improve the only malaria vaccine approved to protect people against Plasmodium falciparum malaria -- the most deadly form of the disease.
Researchers from South Africa and Canada have carried out a Cochrane review update to assess the safety and effectiveness of corticosteroids for treating tuberculous pericarditis.
A University of Colorado Anschutz Medical Campus study finds sotagliflozin helps control glucose and reduces the need for insulin in patients with type 1 diabetes. Principal results were published today in the New England Journal of Medicine of a global Phase 3 clinical trial in patients with type 1 diabetes treated with sotagliflozin. Sotagliflozin has shown promise in improving glucose control without any increase in severe hypoglycemia or diabetic ketoacidosis compared to insulin alone.
There is a broad collection of anomalies now known as congenital Zika syndrome (CZS). Some of the most serious are ophthalmologic. Two papers published in the Journal of the American Association for Pediatric Ophthalmology and Strabismus (AAPOS) evaluated visual function among infants with suspected and confirmed CZS. Both studies found that while about 40 percent of patients had ocular abnormalities, 100 percent of children tested had visual impairment. Thus, cortical visual impairment might be the most common cause of blindness among children with CZS.
If untreated, severe combined immune deficiency (SCID) syndrome -- or 'bubble baby disease' -- is often fatal within the first year of a infant's life. A checklist of SCID markers could make diagnosis faster, allowing more babies to receive treatment within a critical timeframe.