A team of researchers in Japan developed a synthetic molecular code to script gene activation. The process, described in the Journal of the American Chemical Society, could help lead to future gene-based therapies for a wide array of diseases.
Michel Sadelain, M.D., Ph.D., Director, Center for Cell Engineering, Memorial Sloan-Kettering Cancer Center in New York City, offers a fascinating perspective on the re-markable progress being made in the field of chimeric antigen receptor (CAR) engineered T-cell therapies to treat cancer.
Researchers from Case Western Reserve University School of Medicine have discovered how unusually long strands of RNA help colon cancer cells avoid death, allowing unregulated growth. Unlike other RNAs, the intriguing strands do not appear to encode proteins and are termed 'long non-coding RNAs' or 'lincRNAs. 'A new study showed some lincRNAs could be targeted by drug developers to halt colon cancer.
A study from Drexel University showed that restoring a balance between two epigenetic regulator enzymes restored learning and memory function in flies that displayed symptoms of Alzheimer's disease.
Researchers from Columbia University have developed a new technique for the powerful gene editing tool CRISPR to restore retinal function in mice afflicted by a degenerative retinal disease, retinitis pigmentosa.
Findings could allow doctors to predict resistance and lead to changes in treatment. New gene editing technique used to unearth mutation linked to resistance to targeted PARP inhibitor treatments. Scientists have identified a mutation that gives cancer cells resistance to the breakthrough cancer treatment olaparib and other PARP inhibitors.
Scientists investigate new strategy to treat spinal muscular atrophy in infants.
Our bodies are extremely efficient at storing fat from food into our fat tissue. In a new study, researchers from the University of Copenhagen have managed to completely block the development of obesity. The researchers deleted an enzyme and made it impossible for mice to increase their amount of fat tissue, despite the mice eating an extremely fatty diet. They are hoping the findings will open new avenues for better treatment of obesity.
A research team including a researcher from the Faculty of Health and Medical Sciences has discovered a circuit in the brains of mice connecting circadian rhythm to aggressive behaviour. The discovery is particularly interesting to Alzheimer's patients who experience increased aggression at night. The researchers have developed special protein tools capable of turning off the cells in the brain causing the behaviour.
New research published in Nature Communications outlines a strategy that in mouse models significantly delayed the onset of blindness from inherited retinal degeneration such as retinitis pigmentosa.