Relying strictly on genetic data from those of European descent, rather than more diverse populations, can exacerbate existing disease and increase health care disparities, according to new research.
A UC Berkeley team with NSF funding has compiled a roadmap for the future of synthetic or engineering biology, based on the input of 80 leaders in the field from more than 30 institutions. The report provides a strong case that the federal government should invest in this area, not only to improve public health, food crops and the environment, but also to fuel the economy and maintain the country's leadership in synthetic/engineering biology.
Cohesin is a protein complex that plays a key role in cell division; its role in 3D genome structure was described in recent years. Researchers at CNIO have found new functions in the peculiar 3D genome structure of mouse embryonic stem cells. Research on cohesin will help understand how its malfunction contributes to tumorigenesis in some types of cancer, as well as to rare diseases such as Cornelia de Lange syndrome.
A drug that helps regulate bone development has boosted growth rates in children with achondroplasia -- the most common type of dwarfism -- in a trial by Melbourne's Murdoch Children's Research Institute. Phase 2 trial results in children aged 5 to 14 years are published today in the New England Journal of Medicine. The project is now in Phase 3 to test the drug, vosoritide, in a larger group of patients aged 5 to 18 years.
A therapeutic gene delivered into the spinal canal of infant rhesus monkeys was still being expressed after nearly 4 years, with no evidence of acute or chronic neuronal tox-icity, according to a new study published in Human Gene Therapy.
A UCLA-led research team has developed a faster and more accurate way to determine where the many bacteria that live in, and on, humans come from. Broadly, the tool can deduce the origins of any microbiome, a localized and diverse community of microscopic organisms.
Scientists at Columbia have developed a gene-editing tool -- using jumping genes -- that inserts any DNA sequence into the genome without cutting, fixing a major shortcoming of existing CRISPR technology.
A China-US joint research team reported the generation of germline-transmittable cynomolgus macaques with Shank3 mutations, known to cause a form of autism.
The ability to hear depends on proteins to reach the outer membrane of sensory cells in the inner ear. But in certain types of hereditary hearing loss, mutations in the protein prevent it from reaching these membranes. Using a zebrafish model, researchers at Case Western Reserve University School of Medicine have found that an anti-malarial drug called artemisinin may help prevent hearing loss associated with this genetic disorder.
An international team of researchers led by the University of British Columbia has made a scientific advance they hope will lead to the development of preventative treatments for multiple sclerosis (MS).