Live, single-cell imaging shows cellular 'memory' of growth factor availability throughout the cell cycle (and not just snapshot of growth factor availability) influences cells' decision to replicate.
Researchers from King's College London have shown that how we respond to changes in nutrients at a molecular level plays an important role in the aging process, and this is directed by some key genetic mechanisms.
The DNA sequencing of a healthy German shepherd offers scientists new insight into the evolution of the domestic dog while also enabling dogs to be screened for hip and other diseases much more accurately.
Collaboration co-led by researchers at St. Jude Children's Research Hospital discovers a novel predisposition gene in pediatric medulloblastoma.
Houston Methodist nanomedicine researchers are studying a new drug delivery system that transports oral medication via triglycerides that could eliminate the need for injections or IV treatments of some biologic drugs for rheumatoid arthritis and other autoimmune diseases. They're doing this with a diabetes drug that resulted in approximately 25% absorption in mice models, considered very high for an oral drug. The research will appear in Science Advances April 1.
The causes of 40% of all cases of certain medulloblastomas -- dangerous brain tumors affecting children -- are hereditary. These are the findings of a recent genetic analysis carried out by scientists from the European Molecular Biology Laboratory (EMBL) and numerous colleagues around the world. A genetic defect that occurs in 15% of these children plays a key role by destabilizing the production of proteins. The researchers suspect that protein metabolism defects could be a previously underestimated cause of other types of cancer.
Researchers from the University of British Columbia (UBC) and the Central South University (CSU) in China have for the first time identified a gene that increases the risk of Alzheimer's disease.
In a new study, researchers from the University of Copenhagen have mapped how a potent neuropeptide binds to a brain receptor involved in causing human pain. The researchers expect that the mechanism could be exploited as a new avenue for painkilling medicine.
HIV infection and replication within a human cell is a complex mechanism that involves multiple steps and several biochemical factors such as nucleic acids and proteins. Understanding the interplay between these factors has helped researchers to create drugs that target specific viral proteins to drastically slow down viral replication and effectively the progression of AIDS in patients.
They identified a protein that, like a switch, controls the onset of cell death processes in cancer cells, which are regulated by p53, the protein known as 'the guardian of the genome.' The findings will be used to develop more tailored and effective cancer treatments.