Scientists have found that deleting a single gene in a particular strain of gut bacteria causes changes in metabolism and reduced weight gain in mice.
An international team of scientists led by Helmholtz Zentrum München and University of Copenhagen has presented the largest study so far on allergic rhinitis in the journal 'Nature Genetics'. The data of nearly 900,000 participants revealed loci in the human genome whose changes significantly increase the risk of disease.
In a large international study involving almost 900,000 participants, researchers from the University of Copenhagen and COPSAC have found new risk genes for hay fever. It is the largest genetic study so far on this type of allergy, which affects millions of people around the world.
Recent research undertaken by University of Otago Cure Kids Professor Paediatric Genetics, Stephen Robertson, highlights the world-leading discoveries he is making regarding rare genetic disorders affecting children and the opportunity genomic analysis is providing.
In a new study, a team led by University of Utah biologists has discovered that different versions of a single gene, called NDP (Norrie Disease Protein), have unexpected links between color patterns in pigeons, and vision defects in humans. These gene variations were likely bred into pigeons by humans from a different pigeon species and are now evolutionarily advantageous in wild populations of feral pigeons living in urban environments.
How do scale patterns on fish provide understanding of the development of feathers, fur -- and even cancer? Biologists are investigating.
Scientists have long known that RNA encodes instructions to make proteins. The building blocks that comprise RNA--A, U, C, and Gs--form a blueprint for the protein-making machinery in cells. In a new study published in Nature, scientists describe how the protein-making machinery identifies alternative initiation sites from which to start protein synthesis.
A new machine learning framework, dubbed ExPecto, can predict the effects of genetic mutations in the so-called 'dark matter' regions of the human genome. ExPecto pinpoints how specific mutations can disrupt the way genes express throughout your body. Using the method, its creators computed the genetic ramifications of more than 140 million mutations in different tissues. The researchers also precisely pinpointed mutations potentially responsible for increasing the risk of several immune-related diseases, including Crohn's disease.
An international consortium tested nine different methods for RNA sequencing to understand and standardize the best way to sequence small RNAs. The goal was to create a process that could be reproduced from one lab to the next to advance the field of liquid biopsies.
Homology Medicines, Inc., a genetic medicines company, announced today a peer-reviewed publication demonstrating that Homology's technology induces efficient and precise in vivo gene editing. The publication, by senior author Saswati Chatterjee, Ph.D., Department of Surgery, member of the Beckman Research Institute at City of Hope in California, and scientific co-founder of Homology, also highlights the platform's use of homologous recombination, the cells' natural DNA correction pathway, for nuclease-free gene editing.