Researchers from Gero, Skolkovo Institute of Science and Technology (Skoltech), Moscow Institute of Physics and Technology (MIPT), and University of Arkansas for Medical Sciences (UAMS) collaborated to derive a transcriptomic signature of aging, which they confirmed using large transcriptomic databases. They discovered that aging in nematodes is partially programmed and can be therapeutically reversed by a number of FDA-approved drugs.
Genome-wide association studies (GWAS) often turn up a long list of genes that MIGHT help cause the trait of interest. Many algorithms can help scientists prioritize which genes to pursue further, but which one to choose? Borrowing from machine learning, and singling out one chromosome at a time, a new tool called Benchmarker helps scientists evaluate existing algorithms to guide their search for relevant genes.
The anti-tumor protein p53 can decide on the life or death of a cell: If it detects damage in the cell's genome, the protein pushes the cell to suicide. New research conducted at Technical University of Munich (TUM) shows that this inborn cancer prevention only works when special proteins, known as chaperones, allow it to take place.
People who sleep fewer than 7 hours per night have lower levels of gene-regulating molecules, or microRNAs, which help dampen down inflammation in cells and support vascular health.
Most living things have a suite of genes dedicated to repairing their DNA, limiting the rate at which their genomes change through time. But scientists at Vanderbilt and University of Wisconsin-Madison have discovered an ancient lineage of budding yeasts that appears to have accumulated a remarkably high load of mutations due to the unprecedented loss of dozens of genes involved in repairing errors in DNA and cell division, previously thought to be essential.
UC San Diego researchers discover new role for epidermal growth factor receptor in blood stem cell development, a crucial key to being able to generate them in the laboratory, and circumvent the need for bone marrow donation.
An important class of drug used to treat cancer patients could be used to treat brain aneurysms, according to new research published this week.
Investigators at the University of British Columbia (UBC)/Centre for Molecular Medicine & Therapeutics (CMMT) and BC Children's Hospital have examined more than 25 years of data to reveal new insights into predicting the age of onset for Huntington disease.
Fainting is not solely caused by external factors. Your genes also play a part. This has recently been documented by research team from the University of Copenhagen, Statens Serum Institut and Rigshospitalet. Based on data from more than 400,000 individuals they have identified the first gene that predisposes to fainting.
Scientists at the University of Sheffield have discovered how genes create proteins in research which could aid the development of treatments for human diseases.