A method for large-scale production of extracellular vesicles enriched with specific microRNAs (miRNAs) has been developed in the Wake Forest Institute for Regenerative Medicine (WFIRM) labs, offering a manufacturing standardization process which may have therapeutic applications and clinical impact.
A team headed by ICREA researchers Salvador Aznar Benitah and Fran Supek concludes that care should be taken with drugs that inhibit epigenetic factors. Published in Nature Cell Biology, the study is a collaboration between a biomedical lab and a computational lab at IRB Barcelona.
A team of scientists at the Research Institute of the McGill University Health Centre (RI-MUHC) and McGill University have identified three genes responsible for recurrent molar pregnancies, a rare complication that occurs when a non-viable pregnancy with no embryo implants in the uterus. The results of this study, published in The American Journal of Human Genetics, could have important implications, since until now very little is known about the genetic causes of all forms of fetal loss.
New research from King's College London and UCL challenges the idea that a child's weight largely reflects the way their parents feed them. Instead, parents appear to adopt feeding styles in response to their children's natural body weight, which is largely genetically influenced.
Melanoma skin cancer tumors grow larger and are more likely to metastasize due to interactions between a pair of molecules, according to experiments in mice and human cells. The results may restore the potential for a type of cancer therapy previously abandoned in clinical trials. The results also implicate one molecule already connected to obesity and dementia as a potential cause of metastasis, or spread of cancer cells to other areas of the body.
Researchers and clinicians through a multicenter collaboration have identified a novel multisystem disorder caused by bi-allelic variants in the CCDC47 gene. Their findings are reported in the American Journal of Human Genetics. In this study, detailed clinical characterization and functional studies were performed on four unrelated individuals with a complex multisystem disorder characterized by woolly hair, liver dysfunction, itchy skin, unusual facial features, low muscle tone, and global developmental delay.
Researchers at Portland State University discover that vitamin D plays a key role in embryonic development in vertebrates and by blocking vitamin D in embryos of zebrafish, researchers were able to induce dormancy in a species that doesn't enter dormancy. The discovery could have major implications in human health research.
Scientists at the University of Liverpool have uncovered some unexpected 'foreign' genes in the tiny itch-inducing chigger mite and its more benign but enormous cousin, the giant velvet mite. Genome sequencing of these mites, both members of the trombidid mite family, reveals them to have functional genes for producing terpenes -- naturally occurring and often fragrant compounds that are commonly found in plants, but extremely rare in the animal world.
Having certain specific variants of the PATJ gene predisposes to worse recovery from ischemic stroke. 7 out of 10 patients with these variants suffer severe sequelae three months after having a stroke, in other words, they are in a situation of dependence, compared to less than half of patients who do not present these variants.These variants could indicate targets for future treatments that improve stroke prognosis, and enable personalised rehabilitation strategies
A previously unappreciated interaction in the genome turns out to have possibly been one of the driving forces in the emergence of advanced life. This discovery began with a curiosity for retrotransposons, known as "jumping genes," which are DNA sequences that copy and paste themselves within the genome, multiplying rapidly. Researchers inserted a retrotransposon into bacteria, and the results could give depth to the history of how advanced life may have emerged billions of years ago.