On May 5, 2020, news broke about a reportedly more contagious variant of SARS-CoV-2 based on a preprint posted to bioRxiv. On July 2, the journal Cell published a peer-reviewed version of the paper that offers additional experimental and clinical data about the D614G variant suggesting that it may be more infectious, but concludes that we still cannot be certain about whether the variant makes SARS-CoV-2 more transmissible or leads to more severe disease.
A research led by biomedical scientists from City University of Hong Kong (CityU) has developed a novel detection method, called CARPID, to identify binding proteins of specific RNAs in the living cells. It is expected the innovation can be applied in various cell researches, from identifying biomarkers of cancer diagnosis to detecting potential drug targets for treating viral diseases.
Researchers from the MDS Group of the Josep Carreras Leukaemia Research Institute and the Munich Leukemia Laboratory map the mutations that can ease and accelerate the diagnosis of Myelodysplastic/Myeloproliferative Neoplasms rare malignancies.
Problems with brain folding are linked with neurological conditions like autism, anorexia and schizophrenia, but there are currently no ways to detect, prevent or treat misfolding. New research offers genetic insights into the folding process, an important step towards developing potential treatments.
Researchers from the Moscow Institute of Physics and Technology and their colleagues have developed the first technique for personalizing stomach cancer therapy based on RNA sequencing of tumor cells. The study, supported by the Russian Science Foundation, was published in Cold Spring Harbor Molecular Case Studies.
Among a new study's many surprises about synaptic plasticity may be a new approach to addressing Fragile X syndrome: Finding and targeting a "Protein X" that appears to promote shrinkage of dendritic spines.
Researchers have designed a potential new treatment for one of the most common forms of muscular dystrophy, according to a new study published today in the Proceedings of the National Academy of Sciences. Toshifumi Yokota, professor of medical genetics at the University of Alberta, led a team from Canada and the U.S. to create and test synthetic DNA-like molecules that interfere with the production of a toxic protein that destroys the muscles of people who have facioscapulohumeral muscular dystrophy (FSHD).
Many parts of the world are in the midst of a deadly pandemic of cholera, an extreme form of watery diarrhea. UC Riverside scientists have discovered specific gut bacteria make some people resistant to it -- a finding that could save lives.
A new study analyzes the genomes of 29,255 E. coli strains collected between 1884 and 2018 to examine the evolution of 409 different genes that enable the bacterium to resist various antibiotics. The researchers examined whether the genes that confer antibiotic resistance, once acquired, tended to unusually accumulate -- a phenomenon known as "genetic capitalism" -- or disappear because they are unused, through a normal evolutionary process known as "stabilizing selection." Recently, genetic capitalism is found common.
Some neuron types are particularly prone to Alzheimer's, and a new study suggests that those neurons are vulnerable because they regularly remodel. The work is the first to track the progression of Alzheimer's at the genetic and molecular levels within the neurons most susceptible to the disease. The findings suggest that aging and the accumulation amyloid-beta can cause the remodeling process to go awry, creating tangles of tau proteins that lead to neuron death.