This study explores for the first time how the mutation-independent effect of environmental carcinogens leads to the recruitment of CD8+ T cells, the dominant antitumor cell type. Research raises the possibility of an injection of a chemokine known as CCL21 into a tumor to induce an antitumor response through CD8+ T cells.
Genetics plays a major role in determining a person's risk of developing type 1 diabetes, but environmental and lifestyle factors are also important. In an article recently published in Chinese Medical Journal, a team of researchers explore the interplay of genetic and environmental factors by summarizing the literature on type 1 diabetes and epigenetics -- the study of how gene expression patterns can be modified. These findings have important implications in treating type 1 diabetes.
Using neural networks, researchers from the University of Copenhagen have developed a new method to search the human genome for beneficial mutations from Neanderthals and other archaic humans. These humans are known to have interbred with modern humans, but the overall fate of the genetic material inherited from them is still largely unknown. Among others, the researchers found previously unreported mutations involved in core pathways in metabolism, blood-related diseases and immunity.
The extramitochondrial cytochrome C protein may play a protective role in cells subject to low levels of DNA damage, but sentence them to death if the level of damage reaches a tipping point after which repair is impossible.
Researchers from Hiroshima University now have a better understanding of the mechanism underlying how certain bacteria can transfer genetic material across taxonomic kingdoms, including to fungi and protists. Their work, published in Frontiers in Microbiology, could have applications in changing how bacteria perform certain functions or react to changes in their environment.
Forsight to present clinical data of their blood-based MRD detection platform for DLBCL that detects relapse 200 days earlier than other methods.
Scientists have identified key molecular events in the developing human embryo between days 7 and 14 -- one of the most mysterious, yet critical, stages of our development.
The yellow fever mosquito (scientific name, Aedes aegypti) spreads multiple untreatable viruses in humans and is primarily controlled using a pesticide called permethrin. However, many mosquitoes are evolving resistance to the pesticide. A new study by Karla Saavedra-Rodriguez of Colorado State University and colleagues, published in the journal PLOS Genetics, identifies mutations linked to different permethrin resistance strategies, which threaten our ability to control disease outbreaks.
Researchers from Osaka University, along with international collaborators in Europe, have identified Thrombospondin-2 as a serum biomarker that confirms and stratifies the progressive complications of nonalcoholic fatty liver disease. This research may form the basis of a new noninvasive approach that can provide an early warning system for nonalcoholic steatohepatitis and advanced fibrosis and may predict progression to cirrhosis, liver failure and even cancer.
A Clemson University researcher has developed a protein which links natural killer cells in the human body's immune system to breast cancer cells. It's a novel approach to developing breast cancer-specific immunotherapy and could lead to new treatment options for the world's most common cancer.