Researchers at Indiana University School of Medicine have published their work about a specific type of childhood cancer in the peer-reviewed, international oncology journal, Cancers. This research involves a combination therapy that significantly slows tumor growth in models, which includes a model established from cells taken from tumors donated by Tyler Trent.
A team of LSU Health New Orleans researchers reports for the first time that deleting one of the inhibitors of the RPE65 gene in a mouse model that carries a human disease mutation prevents degeneration of cone photoreceptors that are used for daytime high-resolution color vision.
New research found that wild cousins of sorghum, the fifth-most important cereal crop globally, are most concentrated in Australia, despite having been domesticated in Africa. But with 12 of the total 23 wild relative species possibly endangered, four vulnerable, and four near threatened, these economically important wild plants are in peril.
Taking a major step forward in HIV research, scientists at the Lewis Katz School of Medicine at Temple University have successfully edited SIV - a virus closely related to HIV, the cause of AIDS - from the genomes of non-human primates. The breakthrough brings Temple researchers and their collaborators closer than ever to developing a cure for human HIV infection.
A team co-led by a scientist at the University of California, Riverside, has developed a method to study how HIV mutates to escape the immune system in multiple individuals, which could inform HIV vaccine design.
A team of researchers have experimentally measured the social networks of honey bees and how they develop over time. They discovered that there are detailed similarities with the social networks of humans and that these similarities are completely explained by new theoretical modeling, which adapts the tools of statistical physics for biology. The theory, confirmed in experiments, implies that there are individual differences between honey bees, just as there are between humans.
A UCLA study publishing Nov. 27 in Science supports a new conservation strategy. Climate change increasingly makes relocating threatened species necessary, despite the frequently low success rate. The study found tortoises with lots of genetic variation were much more likely to survive after their relocation. The research supports this fast, inexpensive conservation tool, and upends the conventional wisdom suggesting that tortoises from areas moved from close by would fare best.
Scientists from Trinity College Dublin have developed a new gene therapy approach that offers promise for one day treating an eye disease that leads to a progressive loss of vision and affects thousands of people across the globe. The study, which involved a collaboration with clinical teams in the Royal Victoria Eye and Ear Hospital and the Mater Hospital, also has implications for a much wider suite of neurological disorders associated with ageing.
Wheat researchers at the John Innes Centre are pioneering a new technique that promises to improve gene discovery for the globally important crop.
Ataxia is a minority disease with genetic origins, known for its neuromuscular alterations due to the selective loss of neurons in the cerebellum. University of Barcelona researchers have identified new functions in the ataxin 3 gene (ATXN3) -which causes Machado-Joseph disease, the most common type of ataxia- in the development of retina photoreceptors. These results are relevant also to understand other diseases, such as macular degenerations.