Researchers have shown there may be key genetic differences in the causes of attention-deficit hyperactivity disorder (ADHD) between African Americans and people of European ancestry, which may play an important part in how patients of different ethnic backgrounds respond to treatments for this condition.
Researchers from the Structural Bioinformatics and Network Biology Laboratory at IRB Barcelona develop a system to predict tumour response to different treatments. Called Targeted Cancer Therapy for You (TCT4U), this system has allowed them to identify a set of complex biomarkers that are available to the medical-scientific community. The work has been published in the journal Genome Medicine.
In a recent collaboration between the Chinese Academy of Agricultural Sciences and the James Hutton institute, scientists identified a diploid wild potato with a high resistance to Phytophthora infestans. They discovered novel R genes in this potato using dRenSeq analysis, and further transcriptional analysis revealed the essential role of multiple signal transduction pathways and secondary metabolic pathways in plant immunity in the wild potato.
* The researchers studied more than 600,000 genetic variants in the genome of 166 patients treated with the chemotherapy drug capecitabine * Before undergoing treatment, the patients carrying the risk alleles for the hand-foot syndrome had low levels of two proteins that are key to the effective functioning of the skin barrier * The finding may help classify patients according to their genetic risk for developing this side effect of some cancer treatments
Addressing concerns about gene drive releases in the wild, UC San Diego scientists and their colleagues have developed two new genetic systems that halt or eliminate gene drives after release. Created in fruit flies, the e-CHACRs and ERACRs are powerful gene drive control mechanisms that were meticulously developed and tested at the genetic and molecular levels.
By comparing genetic variants differing in the two fly populations, researchers found that polygenic traits led to the quickness of adaptation; many genes, each with very small effects, worked together to determine the rate of development. The research illustrates that crop pests and insect disease vectors with similar biology may rapidly respond to changing climates by a similar genetic mechanism.
A team of international collaborators identifies a new cause of syndromic microcephaly caused by LMNB1 mutations that disrupt the nuclear envelope. The report is published in the October issue of the American Journal of Human Genetics.
For the first time, scientists have studied the early effects of time-restricted feeding on the daily periodic oscillations of metabolites and genes in muscle, and metabolites in blood. The findings by scientists at the University of Copenhagen, the Australian Catholic University and Karolinska Institutet find that time-restricted feeding does not influence the muscle's core clock, and opens the door to more research on how these observed changes improve health.
Princeton researchers Rachel Kaletsky, Rebecca Moore, Coleen Murphy and colleagues have discovered that the microscopic roundworm Caenorhabditis elegans recognizes a small RNA made by a pathogenic bacterium, and uses that RNA to convey learned avoidance of the bacterium to offspring. Their work appears in the Sept. 9, 2020 issue of Nature.
Healthy NEMF helps the cell recycle garbled protein fragments. But several mutant forms resulted in neuromuscular, neurodegenerative or other ALS-like disease, the scientists found.