Is there a link between differences in IQ test performance and the activity of certain genes? Researchers from Charité -- Universitätsmedizin Berlin have shown that modifications in the structure of a specific gene have a negative impact on individual test performance. This suggests that environmentally-induced epigenetic changes to our genetic material have a greater impact on intelligence than previously thought. Results from this study have been published in Translational Psychiatry.
Scientists at Sanford Burnham Prebys Medical Discovery Institute (SBP) have developed new single-cell approaches wedded to machine learning that allow detection of CNVs below one million base pairs. This has revealed thousands of previously unknown DNA changes arising during prenatal life in the developing mouse brain. The researchers also identified when these changes peaked: evidence that potential regulatory mechanisms -- which remain unknown -- are involved. The study published today in PNAS.
Researchers have developed a genome-editing tool for the potential treatment of mitochondrial diseases: serious and often fatal conditions which affect 1 in 5,000 people.
In a paper published Sept. 24 in the journal Nature Plants, an international team of researchers has discovered that the gene FT -- the primary driver of the transition to flowering in plants each spring -- does something unexpected in Arabidopsis thaliana plants grown in natural environments, with implications for the artificial growing conditions scientists commonly used in the lab.
Researchers from Michigan State University College of Human Medicine and physicians from Spectrum Health have identified for the first time in a human patient a genetic disorder only previously described in animal models.
Diabetes is not the only disease on which insulin has an effect, it appears. In a new study that involved tests on mice researchers from the University of Copenhagen, among others, have discovered a new method for treating chronic colitis with regular insulin. The researchers have set up a company with a view to testing the treatment and hopefully making it available to patients.
Genomic screening of more than 50,000 people shows that more than 80 percent of those who carry an identifiable genetic risk for breast, ovarian, prostate, and pancreatic cancer don't know it despite frequent interaction with the healthcare system.
A new study explores the mystery of what drives eating past the point of fullness, at the most basic level in the brain. It shows that two tiny clusters of cells battle for control of feeding behavior -- and the one that drives eating overpowers the one that says to stop. It also shows that the brain's own natural opioid system gets involved -- and that blocking it with the drug naloxone can stop over-eating.
IL1b, a member of the interleukin 1 family of cytokines (proteins released by certain cells of the immune system) drives the inflammation often found in cancer, and appears as an 'IL1 signature' in women with HER2-negative metastatic breast cancer. This signature can not only serve as a diagnostic tool for HER2-negative cancers but also offer an effective treatment target.
A rapid genetic test developed by Newcastle researchers has identified the first four patients with inherited mutations in a new disease gene, a building block of complex I called NDUFA6.