Researchers from the Centre for Genomic Regulation (CRG) have launched a new database to advance the international research efforts studying COVID-19. The publicly available, free-to-use resource an be used by researchers from around the world to study how different variations of the virus grow, mutate and make proteins.
As COVID-19 spreads worldwide, leaders are relying on mathematical models to make public health and economic decisions. A new model developed by Princeton and Carnegie Mellon researchers improves tracking of epidemics by accounting for mutations in diseases. Now, the researchers are working to apply their model to allow leaders to evaluate the effects of countermeasures to epidemics before they deploy them.
Unlocking the full potential of cannabis for agriculture and human health will require a co-ordinated scientific effort to assemble and map the cannabis genome, says a just-published international study led by University of Saskatchewan researchers.
In a new study, researchers have computationally modeled the various brains and bodies of a species of weakly electric fish, the glass knifefish (Eigenmannia virescens), to successfully simulate 'fish brain transplants' and investigate.
For the first time ever, researchers are looking at the molecular processes in the cell's skeleton -- the cytoskeleton -- from a bird's eye perspective. These processes are important for cell movement and cell shape formation. In Nature Cell Biology, an MDC team shows how cells coordinate such processes at the right place and time.
April's Edition of SLAS Technology Features Cover Article, 'CURATE.AI: Optimizing Personalized Medicine with Artificial Intelligence'.
Researchers at the George Washington University published a new knowledgebase and web portal, OncoMX, which will improve the exploration and research of cancer biomarkers in the context of related evidence.
Researchers from the University of Tsukuba developed the novel and publicly available computational tool Millefy to visualize heterogeneity in RNA biology between single cells. Using mouse embryonic stem cells and cells from triple-negative breast cancer patients, they demonstrated the utility of Millefy to identify cell-to-cell variability in read coverage in scRNA-seq data. These findings could help understand disease formation and cancer biology. Millefy is publicly available to the scientific community.
The present study revealed impairment of lipid metabolism in papillae with calcified plaque tissue and down-regulation of fatty acid-binding protein 4 (FABP4) associated with plaque formation. Immunohistochemistry of human kidney specimens and experiments of nephrocalcinosis model mice and Fabp4 knockout mice validated FABP4 down-regulation as an important feature of papillary plaques and stone formation in the kidney. FABP4 appears to be a key molecule and therapeutic target for kidney stone.
Generalized brain atlases, so-called connectome maps, are still no help for identifying neurons in individual, live, wriggling worms. Researchers working towards understanding the brain in high-definition, single-cell detail have designed a new computer program to identify each neuron in fluorescent microscope images of living worms. Previous attempts to automate the identification of individual nerve cells have been thwarted by the fact that the same cell can be in vastly different locations in different worms.