UZH researchers have discovered a previously unknown way in which proteins interact with one another and cells organize themselves. This new mechanism involves two fully unstructured proteins forming an ultra-high-affinity complex due to their opposite net charge. Proteins usually bind one another as a result of perfectly matching shapes in their three-dimensional structures.
Fueled by advances in analyzing DNA from the bones of ancient humans, scientists have dramatically expanded the number of samples studied -- revealing vast and surprising migrations and genetic mixing of populations in our prehistoric past.
A team of American Museum of Natural History researchers has created a computational model capable of predicting whether or not organisms have the ability to 'eat' other cells through a process known as phagocytosis. The model may be a useful tool for large-scale microbe surveys and provides valuable insight into the evolution of complex life on Earth, challenging ideas put forward in recent studies.
The pursuit of the usual suspect in Alzheimer's research may be distracting from a more direct culprit in the disease, according to a study that analyzed data from 51 published experiments. P-tau looked a good bit more culpable than amyloid-beta plaque.
The global 1000 Bull Genomes Consortium identified the genetic basis for accurately predicting the complex trait of height across cattle and dairy breeds by pooling large genomic datasets and phenotypes collected from 58,000 cattle. The team validated their findings using the DNA of a wild auroch, the ancient ancestor to all cattle and dairy breeds, and, in a world first, demonstrated the genes influencing height in cattle also influence the trait in humans and dogs.
Butterflies offer key insights into community ecology, how species originate and evolve, climate change and interactions between plants and insects. But a comprehensive map of how butterflies are related to each other has been lacking -- until now.
In a paper in Cell Host & Microbe, scientists provide a statistical model predicting which bacterial strains will engraft after a fecal transplant. It is the first predictive strategy for developing a synthetic probiotic. The researchers also found that recipients acquired new bacteria that were previously undetected in both the donor and the recipient, suggesting that the post-fecal transplant microbiome is a mixture of bacterial strains from the donor, recipient, and the environment.
International team of scientists led by Roderic Guigó at the Centre for Genomic Regulation (CRG) in Barcelona shows that changes in gene expression in different tissues can be used to predict the time of death of individuals. Their results, which are published in Nature Communications this week, may have implications for forensic analyses.
A novel approach to studying cancer has enabled researchers to group about 10,000 human cancers of 32 different types into 10 classes based on the molecular pathways that drive tumor growth. A better understanding of these pathways can potentially lead to novel ways to diagnose and treat cancer.
Scientists from the Helmholtz Zentrum München have developed a program that is able to help manage enormous datasets. The software, named Scanpy, is a candidate for analyzing the Human Cell Atlas, and has recently been published in Genome Biology.