Scientists introduce ORTHOSCOPE, a new web-based tool capable of inferring gene function, estimating gene trees and identifying sets of ancestral genes in just minutes.
Scientists at the Francis Crick Institute have discovered a set of surprisingly simple rules that determine the precision of CRISPR/Cas9 genome editing in human cells. These rules could help to improve the efficiency and safety of genome editing in both the lab and the clinic.
Microorganisms perform key functions in ecosystems and their diversity reflects the health of their environment. Researchers from UNIGE use genomic tools to sequence the DNA of microorganisms in samples, and then exploit this considerable amount of data with artificial intelligence. They build predictive models capable of establishing a diagnosis of the health of ecosystems and identify species that perform important functions. This new approach will significantly increase the observation capacity of large ecosystems.
Scientists are revising the history of one of the world's most important crops. Drawing on genetic and archaeological evidence, researchers have found that a predecessor of today's corn plants still bearing many features of its wild ancestor was likely brought to South America from Mexico more than 6,500 years ago. Farmers in Mexico and the southwestern Amazon continued to improve the crop over thousands of years until it was fully domesticated in each region.
Research shows for the first time that when adults are engaged in joint play together with their infant, the parents' brains show bursts of high-frequency activity, which are linked to their baby's attention patterns and not their own. The study publishes December 13 in the open-access journal PLOS Biology and was conducted by Dr Sam Wass of the University of East London in collaboration with Dr Victoria Leong (Cambridge University and Nanyang Technological University, Singapore) and colleagues.
University of Alberta scientists have identified three biomarkers for detecting mild cognitive impairment and Alzheimer's disease in saliva samples. The research has promising results for application in a clinical setting.
Quantum biology, a young and increasingly popular science genre, isn't as new as many believe, with a complicated and somewhat dark history, explain the founders of the world's first quantum biology doctoral training center.
An analysis of nearly 20,000 cancer patient histories and genetic data has revealed that knowing the genetic cause of a cancer does not help predict how deadly the disease will be. Instead, researchers from CSHL have discovered that copy number variations in specific gene sites are far more informative, providing new opportunities to improve prognosis.
Researchers at LSTM have used a bioinformatics approach to integrate information from multiple studies on insecticide resistance in mosquitoes and uncovered a number of important resistance mechanisms that had not previously been recognised.
Scientists at the University of Würzburg have been able to boost current super-resolution microscopy by a novel tweak. They coated the glass cover slip as part of the sample carrier with tailor-made biocompatible nanosheets that create a 'mirror effect'. This method shows that localizing single emitters in front of a metal-dielectric coating leads to higher precision, brightness and contrast in Single Molecule Localization Microscopy (SMLM). The study was published in the Nature journal Light: Science and Applications.