Researchers at the Medical University of South Carolina discovered a new mechanism for a class of anti-cancer drugs known as E1 inhibitors. Their findings, published in Nature Communications on Dec. 4, 2018, reveal a novel binding site that will promote drug design of more efficient E1 inhibitors.
Scientists at the University of Colorado Anschutz Medical Campus have implicated a largely hidden part of the human genome in the severity of autism symptoms, a discovery that could lead to new insights into the disorder and eventually to clinical therapies for the condition.
A cutting-edge technique called cellular barcoding has been used to tag, track and pinpoint cells responsible for the spread of breast cancer from the main tumour into the blood and other organs. Dr Delphine Merino, Dr Tom Weber, Professor Jane Visvader, Professor Geoffrey Lindeman and Dr Shalin Naik led the highly collaborative research that involved breast cancer biologists, clinician scientists, biotechnologists and computational experts at the Walter and Eliza Hall Institute of Medical Research.
Laminitis -- a complex, common and often devastating disease -- is the second biggest killer of domestic horses. Now a body of important research on it, from QUT and other organizations, has been compiled and shared online by the Equine Veterinary Journal for vets and others to access.
Scientists of the Pacific Institute of Bioorganic Chemistry (PIBOC) of the Far Eastern Branch of the Russian Academy of Sciences (FEB RAS) and the Far Eastern Federal University (FEFU) found out marine invertebrates living in Troitsa Bay, the Sea of Japan, contain biologically active compounds with strong antitumor and antimicrobial properties, and also capable of killing insects. An article on that was published in the Russian Journal of Marine Biology.
Although magnetic nanoparticles are being used more and more in cell imaging and tissue bioengineering, what happens to them within stem cells in the long term remained undocumented. Researchers have shown substantial degradation of these nanoparticles, followed in certain cases by the cells "re-magnetizing." This phenomenon is the sign of biosynthesis of new magnetic nanoparticles from iron released in the intracellular medium by the degradation of the first nanoparticles.
Using a small and inexpensive biosensor, researchers in the School of Engineering have developed a novel low-cost technique that quickly and accurately detects cryptosporidium contamination in water samples.
Using Shrinky Dinks, a popular children's toy, engineers at the University of California, Irvine have created wearable, disposable respiration sensors that track the rate and volume of a wearer's breath. The new device will help sufferers of asthma and many other pulmonary conditions.
Biomedical engineers at Duke University have demonstrated how photoacoustic imaging can take the temperature of deep tissue more quickly and accurately than current techniques. This discovery is expected to play an important role in advancing thermal-based therapies to treat cancer.
Plastic bag pollution has become a huge environmental problem, prompting some cities and countries to heavily tax or ban the sacks. But what if used plastic bags could be made into higher-value products? Now, researchers have reported a new method to convert plastic bags into carbon chips that could be used as anodes for lithium-ion batteries. They report their results in ACS Omega.