Biochips are driving next-generation DNA sequencing technologies, and this powerful combination is capable of solving unique and important biological problems, such as single-cell, rare-cell or rare-molecule analysis, which next-generation sequencing can't do on its own. In APL Bioengineering, researchers from Seoul National University explore the role advancements in biochip technology are playing in driving groundbreaking scientific discoveries and breakthroughs in medicine via next-generation sequencing, aka high-throughput sequencing.
Ana Buj Bello's team, a researcher in an Inserm unit at Genethon, the AFM-Telethon laboratory, has made the proof-of-concept of a CRISPR-Cas9 approach in a mouse model of Steinert's myotonic dystrophy, the most common neuromuscular disease in adults.
Researchers have shown for the first time that these insects use different directional sensors to achieve the highest possible navigational precision in different conditions.
For the first time, scientists can record cells communicating in real time, opening the floodgates for new developments in cell therapy and other areas within cell biology.
In July's SLAS Discovery feature article, '3D Cell-Based Assays for Drug Screens: Challenges in Imaging, Image Analysis, and High-Content Analysis,' Tijmen H. Booij, Ph.D., Screening Specialist for NEXUS Personalized Health Technologies (Switzerland), discusses the switch from using 2D to 3D cell cultures in drug discovery to more accurately mimic human physiological conditions and improve the success rates of drugs in the early stages of preclinical drug discovery.
SHERLOCK technology is a new CRISPR-based platform that is rapid and portable and enables detection and quantitation of plant genes to support a variety of agricultural applications. Additional advantages, including the ability to process crude plant extracts with minimal nucleic acid sample preparation required are described in a research article published in The CRISPR Journal, a new peer-reviewed journal from Mary Ann Liebert, Inc., publishers.
For the first time, scientists have been able to study how well synthetic bone grafts stand up to the rigors and 'strains' of life, and how quickly they help bone re-grow and repair.
Time-saving method makes it possible to profile gene regulation in tens of thousands of individual human cells in a single day. Approach combines microfluidics and novel software to scale up single-cell ATAC-seq, which identifies parts of the tightly packaged genome that are more open and accessible to regulatory proteins. Profiling individual cells can clarify how genes function -- in which specific cell types, at what time -- and whether they play a role in disease.
A new family of enzymes has been engineered to perform one of the most important steps in the conversion of plant waste into sustainable and high-value products such as nylon, plastics and chemicals.
Zillionaires like Amazon founder Jeff Bezos who see the 'colonization' of space as an answer to the Earth's ever threatened resources will be reassured to learn that human sperm retains its complete viability within the different gravitational conditions found in outer space.