Researchers at Duke University have created a framework for helping bioengineers determine when to use multiple lines of cells to manufacture a product. The work could help a variety of industries that use bacteria to produce chemicals ranging from pharmaceuticals to fragrances.
Ultra-deep DNA sequencing of thousands of cells uncovers many competing mechanisms of evolution as a threat to efficient scale-up of biobased chemicals production. Evolution plays an underestimated role in bioprocesses and limits yields much more than previously anticipated.
Scientists at the UNC School of Medicine and NC State have created an injectable gel-like scaffold that can hold combination chemo-immunotherapeutic drugs and deliver them locally to tumors in a sequential manner. The results in animal models so far suggest this approach could one day ramp up therapeutic benefits for patients bearing tumors or after removal of the primary tumors.
A perspective article in the March 2018 issue of SLAS Discovery from the biology group at the European Screening Centre Newhouse details how the European Lead Factory (ELF), a large publicly accessible drug discovery platform, uses microscale thermophoresis (MST) to aid in the prioritization of small molecule hits from high-throughput screening.
A new special report examines how we can make wise policy decisions about emerging technologies.
A new University of Chicago study shows how tiny, light-powered wires could be fashioned out of silicon to manipulate electrical signaling between neurons. Published Feb. 19 in Nature Nanotechnology, the study offers a new avenue to shed light on -- and perhaps someday treat -- brain disorders.
EPFL scientists have found that the activity of proprotein covertases, the enzymes that turn-on proteins, is regulated by the location of the enzyme inside the cell. Published in Cell Reports, the study uses a novel biosensor, CLIP, and has significant implications for cancer treatment.
Australian biomedical engineers have developed a 3-D material that successfully mimics nature to transform cells into muscle.
Protein nanofibres often have outstanding properties such as a high stability, biodegradability, or antibacterial effect. Artificially creating these fibres is not easy, much less assigning them specific functions. That and how fibres with new properties can be successfully created is now being reported by materials scientists from Jena (Germany) in the latest issue of the renowned journal 'ACS NANO' (DOI: 10.1021/acsnano.7b07196).
Circumventing evolution in cell factories can pave the way for commercializing new biobased chemicals to large-scale.