A method for large-scale production of extracellular vesicles enriched with specific microRNAs (miRNAs) has been developed in the Wake Forest Institute for Regenerative Medicine (WFIRM) labs, offering a manufacturing standardization process which may have therapeutic applications and clinical impact.
New research publishing Nov. 20 in the open-access journal PLOS Biology from Joshua Wallach, Kevin Boyack, and John Ioannidis suggests that progress has been made in key areas of research transparency and reproducibility. The authors randomly sampled biomedical journal articles published between 2015 and 2017 and assessed measures of reproducibility and transparency.
Researchers and clinicians through a multicenter collaboration have identified a novel multisystem disorder caused by bi-allelic variants in the CCDC47 gene. Their findings are reported in the American Journal of Human Genetics. In this study, detailed clinical characterization and functional studies were performed on four unrelated individuals with a complex multisystem disorder characterized by woolly hair, liver dysfunction, itchy skin, unusual facial features, low muscle tone, and global developmental delay.
Does engaging patients in research projects improve health? A comprehensive collection -- from youth involvement in mental health services to suicide prevention, Indigenous health, children with complex medical needs and more -- highlights the value of patient engagement in research.
Researchers developed a versatile remote gaming interface that allowed experts as well as hundreds of citizen scientists all over the world through multiplayer collaboration and in real time to optimize a quantum gas experiment in a lab at Aarhus University. Both teams quickly used the interface to dramatically improve upon the previous best solutions, that scientists had established after months of careful optimization. The experiment aims to unravel how humans solve complex, natural science problems.
In seeking to pinpoint why black or African-American scientists are less likely than their white counterparts to receive National Institutes of Health research funding, a group of researchers has identified early career publications as a likely contributor to the gap.
An analysis of major health research prizes, including the Canada Gairdner International Award, found that few Canadian-based scientists are winning these prestigious prizes. The article is published in CMAJ (Canadian Medical Association Journal).
Meetings are the bane of office life for many professionals but they don't have to be. Drawing from almost 200 scientific studies on workplace meetings, a team of psychological scientists provides recommendations for making the most out of meetings before they start, as they're happening, and after they've concluded.
A wide ranging international study that genetically analysed the DNA of a series of famous and controversial ancient remains across North and South America has discovered that the Spirit Cave remains -- the world's oldest natural mummy - was a Native American. They were also able to dismiss a longstanding theory that a group called Paleoamericans existed in North America before Native Americans.
In the first study of its kind, published in the Annals of Tourism Research, academics from the University of Surrey and the University of Oxford have examined how Autonomous Vehicles (AVs) may have a substantial impact on the future of urban tourism.