Mount Sinai Scientists developed a novel way to barcode and track different CRISPRs by utilizing synthetic proteins built from combinations of smaller proteins, called epitopes. By being able to mark each CRISPR with a unique identifier, the protein barcodes, or Pro-Codes for short, enable hundreds of CRISPRs to be used together to knockout a multitude of genes.
A new Florida State University College of Medicine study in mice produced results that suggest nicotine exposure in men could lead to cognitive deficits in their children and grandchildren. Further studies will be required to know if the same outcomes seen in mice would apply to humans.
Among several forms of pancreatic cancer, one of them affects specifically women, often young, even though the pancreas is an organ with little exposure to sex hormones. This pancreatic cancer, known as 'mucinous cyst,' has strange similarities with another mucinous cancer, affecting the ovaries. By conducting large-scale analyses of genomic data, researchers at the University of Geneva and at the University Hospitals of Geneva have provided an answer: both tumors originate from embryonic germ cells.
This study shows that Src is necessary and sufficient to activate mTORC1 and offers the possibility to develop novel approaches to control cancer growth.
Microorganisms often assemble natural products similar to industrial assembly lines. Certain enzymes, non-ribosomal peptide synthetases (NRPS) play a key role in this process. Biotechnologists at Goethe University have now been able to discover how these enzymes interact with each other. This brings them one step closer to their goal of engineering the production of such peptide natural products.
In the ongoing chemical battles among bacteria and their microbial neighbors, a new toxin has been uncovered. This unfamiliar toxin behaves in a familiar way. Its actions against other bacteria resemble the mechanisms of cholera, pertussis and diphtheria toxins. Some bacteria deploying this toxin have safeguards against self-poisoning.
New study shows that some bacterial pathogens, including those that cause strep throat and pneumonia, are able to create the components necessary to replicate their DNA using a ribonucleotide reductase enzyme that does not require a metal ion cofactor.
Computational image analysis of behaving cuttlefish reveals principles of control and development of a biological invisibility cloak.
Researchers have for the first time been able to investigate the abundance and methyl modifications of all mitochondrial tRNAs in patients suffering from one of the most common inherited mitochondrial tRNA mutations. The analysis pipeline revealed quantitative changes that had dramatic effects on protein synthesis within mitochondria.
Allergen-specific immunotherapy can considerably improve everyday life for allergy sufferers. It is unclear, however, what exactly happens during this treatment. A team at the Technical University of Munich (TUM) and Helmholtz Zentrum München investigated the processes taking place in the body over the course of a three-year allergen-specific immunotherapy. The researchers found clues as to why the allergy immunization takes so long and how the chances of success can be determined at a very early stage.