Researchers discover a mechanism that causes cell nuclei to grow.
Researchers from the Structural Bioinformatics and Network Biology Laboratory at IRB Barcelona develop a system to predict tumour response to different treatments. Called Targeted Cancer Therapy for You (TCT4U), this system has allowed them to identify a set of complex biomarkers that are available to the medical-scientific community. The work has been published in the journal Genome Medicine.
The kidneys often become bulky and dysfunctional in diabetes, and now scientists have found that one path to this damage dramatically reduces the kidney's ability to clean up after itself.
Scientists at Cincinnati Children's used human intestinal organoids grown from stem cells to discover how our bodies control the absorption of nutrients from the food we eat. They further found that one hormone might be able to reverse a congenital disorder in babies who cannot adequately absorb nutrients and need intravenous feeding to survive.
Radio-resistance in bacteria first evolves through the adaptation of DNA repair mechanisms, however as evolution continues more mutations accumulate, and more cellular metabolic processes are affected. It is not yet clear which panel of mutations provides high-level resistance. The study shows that acquisition of radio-resistance via evolution is possible independent of other mechanisms like extreme dryness resistance (desiccation).
Scientists have developed a new tool that mimics how the virus that causes COVID-19 infects a cell, potentially speeding the search for treatments against the disease. The tool is a fluorescent nanoparticle probe that uses the spike protein on the virus surface to bind to cells and trigger the process that pulls the virus into cells. The probe could be used to rapidly gauge how drugs and compounds might block the virus from infecting cells.
A new study led by Boston Medical Center researchers indicates a well-known biomarker that serves as a marker for earlier diagnosis of neurodegenerative diseases is now detectable in the eye. Neurofilament light chain, a protein previously detected in cerebrospinal fluid and blood that is being explored as a biomarker to detect neurodegeneration, has now been identified in the vitreous humor, or fluid within the eye.
New research has uncovered the previously unknown presence of CD19 -- a B cell molecule targeted by chimeric antigen receptor (CAR) T cell immunotherapy to treat leukemia, lymphoma, and multiple myeloma -- in brain cells that protect the blood brain barrier (BBB). This discovery may potentially be the cause for neurotoxicity in patients undergoing CD19 directed CAR T cell immunotherapy, according to the research team led by Avery Posey, PhD, an assistant professor of Systems Pharmacology and Translational Therapeutics at the University of Pennsylvania.
* The researchers studied more than 600,000 genetic variants in the genome of 166 patients treated with the chemotherapy drug capecitabine * Before undergoing treatment, the patients carrying the risk alleles for the hand-foot syndrome had low levels of two proteins that are key to the effective functioning of the skin barrier * The finding may help classify patients according to their genetic risk for developing this side effect of some cancer treatments
This study aims at investigating the antimicrobial and antibiofilm effect of rosemary and ginger essential oil-based nano-sized formulations on colistin resistant K. pneumonia clinical isolates.