News by Subject Biology

A CALCR cell found in mice may stop feeding without subsequential nauseating effects, as well as influence the long term intake of food.

A study led by Dr. Pnina Brodt shows that the liver immune microenvironment reacts to metastatic cells differently in male and that in female mice and estrogen can indirectly contribute to the growth of metastases. These findings provide a rationale for further exploration of the role of sex hormones in female cancer patients and the potential benefits of anti-estrogen drugs such as tamoxifen in the treatment of hormone-independent cancers that metastasize to the liver.

University of Colorado Cancer Center study shows that cancer-causing MLL gene may also push pluripotent stem cells to make hematopoietic stem cells, a strong step in the decades-long effort to make personalizable, durable blood stem cells.

For the first time, research shows that the contacts between cells, known as cell adhesion, are essential for cells to survive stress. The findings also suggest that impaired cell adhesion may sensitize cancer cells to drugs that damage cell proteins and cause stress.

Whether a sick cell dies, divides, or travels through the body is regulated by a sophisticat-ed interplay of signal molecules and receptors on the cell membrane. One of the most im-portant molecular cues in the immune system is Tumour Necrosis Factor α (TNFα). Now, for the first time, researchers from Goethe University have visualised the molecular organ-isation of individual TNFα receptor molecules and the binding of TNFα to the cell mem-brane in cells using optical microscopy.

Garvan researchers have revealed changes to the 3D arrangement of DNA linked to treatment resistance in ER+ breast cancer.

A UC San Francisco-led research team has discovered the first conclusive evidence that selection may also occur at the level of the epigenome -- a term that refers to an assortment of chemical "annotations" to the genome that determine whether, when and to what extent genes are activated -- and has done so for tens of millions of years.