Colorado study sequences 33 canine cancer cell lines to identify 'human' genetic changes could be driving these canine cancers, possibly helping veterinary oncologists use more human medicines to cure cancer in dogs.
Columbia researchers have created a way to grow human hair in a dish, which could open up hair restoration surgery to more people, including women, and improve the way pharmaceutical companies search for new hair growth drugs.
Biochips are driving next-generation DNA sequencing technologies, and this powerful combination is capable of solving unique and important biological problems, such as single-cell, rare-cell or rare-molecule analysis, which next-generation sequencing can't do on its own. In APL Bioengineering, researchers from Seoul National University explore the role advancements in biochip technology are playing in driving groundbreaking scientific discoveries and breakthroughs in medicine via next-generation sequencing, aka high-throughput sequencing.
Researchers develop molecular testing to distinguish patients who may need less from those who may need more therapy for HER2 positive breast cancer.
To better understand the cells that brain tumors recruit, scientists developed advanced imaging techniques to visualize macrophages.
Altered blood flow resulting from heart injury switches on a communication cascade that reprograms heart cells and leads to heart regeneration in zebrafish.
Ion channels are pores in the membrane of cells or cell organelles that allow ions to be transported across the membrane. Biochemists have now succeeded in imaging an important regulatory region of the human TRPML2 calcium ion channel at high resolution, an area of the channel shaped like a large ring on one side of the membrane. This ring acts like a doorman, deciding whether ions can move through the channel.
Researchers from Hong Kong Baptist University have found that the abnormal rise of a soluble protein called Nerve Growth Factor is a key factor linking early life stress to the development of irritable bowel syndrome.
The thymus, a vital organ producing the immune system's T cells, is one of the first to diminish in function as we age, resulting in a gradual loss of T cell production and eventually increased susceptibility to infections and cancer. Researchers have identified factors affecting the cells in the thymus that set in motion this loss, paving the way to develop targeted strategies for the recovery of T cells to help combat infections and cancers.
In a new study, published on June 25, 2019, in the journal eLife, the researchers report that higher levels of doublets -- long dismissed as technical artifacts -- can be found in people with severe cases of tuberculosis or dengue fever.