Just as the skeleton and muscles move the human body and hold its shape, the cells of the body are stabilised and moved by a cellular skeleton. This cellular skeleton is a dynamic structure, constantly changing and renewing. It consists of different types of protein filaments, which include intermediate filaments and microtubules. Researchers from Göttingen University are the first to succeed in observing a direct interaction between microtubules and intermediate filaments outside the cell, and in measuring this.
Will a reduction in tau protein in brain neurons protect against Parkinson's disease and Lewy body dementias? A new study suggests the answer is no. If this is borne out, that result differs from Alzheimer's disease, where reducing endogenous tau levels in brain neurons is protective for multiple models of the disease -- and thus suggests that the role of tau in the pathogenesis of Lewy body dementias is distinct from Alzheimer's disease.
A new scientific study published in Nature Catalysis shows that baker's yeast can be designed and optimised to produce polyamines and polyamine analogues for tackling grand challenges in both the health and agricultural sector.
Researchers from Kanazawa University have found that gasdermin D, a protein known to be involved in cell death, is crucial for maturation and release of interleukin-1α, an important inflammatory mediator. When the inflammasome is activated, caspase-1 cleaves gasdermin D into two parts: one of these parts travels to the membrane, where it forms a pore that allows calcium influx and activation of calpains, promoting interleukin-1α activation and exit from cells.
Scientists at Sanford Burnham Prebys have gained a deeper insight into the intricacies of autophagy, the process in which cells degrade and recycle cellular components.
A signaling protein thought to be able to treat liver damage in paracetamol toxicity could actually worsen it. Instead, Singapore scientists discovered, blocking its effects could be the way forward.
Researchers at the University of Chicago's Pritzker School of Molecular Engineering and Biological Sciences Division have developed a combined imaging and machine learning technique that can, for the first time, measure a metabolic process at both the cellular and sub-cellular levels.
UC San Diego School of Medicine researchers discovered that the enzyme RNA polymerase II recognizes and transcribes artificially added base pairs in genetic code, a new insight that could help advance the development of new vaccines and medicines.
KIYATEC announces clinical study data showing test accurately predicts brain cancer patient response to standard drug therapy prior to treatment.
By cleverly combining complementary sequencing techniques, researchers of Ghent University, together with Baylor College of Medicine and the world's leading sequencing company, Illumina, have deepened our understanding of the function of known RNA molecules and discovered thousands of new RNAs. A better understanding of our transcriptome is essential to better understand disease processes and uncover novel genes that may serve as therapeutic targets or biomarkers.