Researchers at the Medical University of South Carolina discovered a new mechanism for a class of anti-cancer drugs known as E1 inhibitors. Their findings, published in Nature Communications on Dec. 4, 2018, reveal a novel binding site that will promote drug design of more efficient E1 inhibitors.
In a recently published paper, the University of Pittsburgh's Takashi D. Y. Kozai detailed a less invasive method of neural stimulation that would use an untethered ultrasmall electrode activated by light, a technique that may mitigate damage done by current methods.
Laminitis -- a complex, common and often devastating disease -- is the second biggest killer of domestic horses. Now a body of important research on it, from QUT and other organizations, has been compiled and shared online by the Equine Veterinary Journal for vets and others to access.
Rice University researchers have created a method to design custom masks that transform 2D fluorescent microscopy images into 3D movies.
Using a novel optogenetic tool, researchers have successfully controlled, reproduced and visualized serotonin receptor signals in neural cells. To this end, they modified a photosensitive membrane receptor in the eye, namely melanopsin. They were able to switch the receptor on and off using light; it also acted like a sensor indicating via fluorescence if specific signalling pathways in the cell had been activated. The sensor was, moreover, specifically designed to migrate to those domains in the neural cells that are sensitive to the neurotransmitter serotonin.
Although magnetic nanoparticles are being used more and more in cell imaging and tissue bioengineering, what happens to them within stem cells in the long term remained undocumented. Researchers have shown substantial degradation of these nanoparticles, followed in certain cases by the cells "re-magnetizing." This phenomenon is the sign of biosynthesis of new magnetic nanoparticles from iron released in the intracellular medium by the degradation of the first nanoparticles.
Using a small and inexpensive biosensor, researchers in the School of Engineering have developed a novel low-cost technique that quickly and accurately detects cryptosporidium contamination in water samples.
Using Shrinky Dinks, a popular children's toy, engineers at the University of California, Irvine have created wearable, disposable respiration sensors that track the rate and volume of a wearer's breath. The new device will help sufferers of asthma and many other pulmonary conditions.
A new reversible, drug-free antiplatelet therapy could reduce the risk of blood clots and potentially prevent cancer metastasis, according to a study published today in Science Translational Medicine.
We use our wrists constantly, but how do they work? In a just-published Journal of Biomechanics article, UC Davis researchers proved a longtime assumption about individuals' right and left wrists, while also finding differences between wrists of males and females: discoveries that could help inform and guide future treatments.