Researchers from the Moscow Institute of Physics and Technology, working with Spanish, French, and German colleagues, have determined and analyzed the high-resolution structure of a protein from the recently discovered heliorhodopsin family. Microbial rhodopsins play a key role in optogenetics -- a technique that uses light to control nerve and muscle cells in living tissue.
New artificial proteins have been created to function as molecular logic gates. Like their electronic counterparts in computers, these biochemical tools can be used to program the behavior of complex systems, such as gene regulation inside human T-cells. This new advance might improve the durability of future cell-based therapies.
A potential COVID-19 vaccine, delivered by microscopic needles, produces antibodies specific to the virus when tested in mice. This is the first peer-reviewed paper describing a COVID-19 vaccine candidate. The next step is a human clinical trial.
The DNA sequencing of a healthy German shepherd offers scientists new insight into the evolution of the domestic dog while also enabling dogs to be screened for hip and other diseases much more accurately.
MIT researchers have developed a urine test that can offer early detection of proteins linked to lung cancer. The diagnostic sensor, developed by a team led by Sangeeta Bhatia, is based on nanoparticles that can be injected or inhaled.
Houston Methodist nanomedicine researchers are studying a new drug delivery system that transports oral medication via triglycerides that could eliminate the need for injections or IV treatments of some biologic drugs for rheumatoid arthritis and other autoimmune diseases. They're doing this with a diabetes drug that resulted in approximately 25% absorption in mice models, considered very high for an oral drug. The research will appear in Science Advances April 1.
LAL is an essential biotech resource for sterility testing of medical devices, but harvesting horseshoe crabs from the ocean to produce it puts pressure on vulnerable animal populations. In a new study, researchers have developed an animal-friendly, sustainable aquaculture method that yields an extra-potent LAL that can check for sepsis-causing bacteria and fungi in human blood.
In this study, they compare two sequencing methods and design a bioinformatic analysis to establish the basis of a wide study in the research of early detection markers of colon cancer.
A research team at the German Leibniz Institute for Zoo and Wildlife Research (Leibniz-IZW) developed a method to isolate and cryopreserve testicular cells. This will allow the safekeeping and biobanking of gametes and other cells of the male reproductive tract of threatened or endangered feline species. The findings have been published in the scientific journal 'Cryobiology.'
HIV infection and replication within a human cell is a complex mechanism that involves multiple steps and several biochemical factors such as nucleic acids and proteins. Understanding the interplay between these factors has helped researchers to create drugs that target specific viral proteins to drastically slow down viral replication and effectively the progression of AIDS in patients.