A team at Princeton's Lewis-Sigler Institute for Integrative Genomics has produced new resources for research involving the roundworm C. elegans: a comprehensive view of which genes are active in each of the four major tissues of adult worms, as well as a tool for predicting gene activity across 76 more specific cell types.
For the first time ever, an international research group detected alterations in capillary blood flow around the face caused by body position change. This became possible through the use of imaging photoplethysmography. Using this method, scientists can examine blood vessels located in the carotid system in order to, for example, investigate the cerebral blood flow response to various stimuli in health and disease. The results of the research were published in Scientific Reports.
Researchers at the University of Pennsylvania have found a new common thread linking nearly all of the trinucleotide repeat expansion diseases, which include ALS, Huntington's Disease and Fragile X Syndrome, involving the complicated 3D patterns that the DNA is folded into in order to fit in the nucleus of the cell. Nearly all of the short tandem repeats known to grow unstable in disease are located at the boundaries that separate neighboring folded domains.
A multidisciplinary team of researchers at the National University of Singapore (NUS) has developed a portable, easy-to-use device for quick and accurate screening of diseases. This versatile technology platform called enVision (enzyme-assisted nanocomplexes for visual identification of nucleic acids) can be designed to detect a wide range of diseases - from emerging infectious diseases (e.g. Zika and Ebola) and high-prevalence infections (e.g. hepatitis, dengue, and malaria) to various types of cancers and genetic diseases.
Our result suggests preoperative albumin level as an independent risk factor for PPCs in elderly gastric cancer (GC) patients after elective laparoscopic gastrectomy. We also suggest that those elderly hypoalbuminemic GC patients may benefit from more intensive perioperative care including perioperative nutritional status improvement.
A research group at KAIST has developed an engineered E. coli strain that converts formic acid and CO2 to pyruvate and produces cellular energy from formic acid through reconstructed one-carbon pathways. The strategy described in this study provides a new platform for producing value-added chemicals from one-carbon sources.
With age, expression of a small molecule that can silence others goes way up while a key signaling molecule that helps stem cells make healthy bone goes down, scientists report.
University of Oregon chemists have created a new class of fluorescent dyes that function in water and emit colors based solely on the diameter of circular nanotubes made of carbon and hydrogen.
By creating a new twist on fiber optic sensors, researchers in China have developed a smart, flexible photoacoustic imaging technique that may have potential applications in wearable devices, instrumentation and medical diagnostics.
Surf's up for microbes swimming beside red blood cells. New calculations and experiments model for the first time how spherical particles submerged in gooey liquid travel along a flexible rubber sheet; comparable conditions are common in the human body, such as blood cells flowing through a capillary or the journeys of self-propelled microbes. All these particles, it turns out, catch a wave.