An online database of study summaries could be systematically evaluated to uncover new information about animal testing, including potential targets for efforts to minimize harm to lab animals. A demonstration of this approach is publishing Dec. 14 in the open-access journal PLOS Biology.
Dr. Lisa Lindley and colleagues examined birth happiness among women by sexual orientation discordance using data from the 2006-2015 National Survey of Family Growth. They found that women's sexual orientation discordance was linked to (un)happiness about birth.
Gene editing has begun to be tested in clinical trials, using CRISPR-Cas9 and other technologies to directly edit DNA inside people's cells, and multiple trials are recruiting or in planning. A new study raises a note of caution, finding person-to-person genetic differences that may undercut the efficacy of gene editing or, more rarely, cause potentially dangerous 'off target' effects. It suggests that gene editing may need to be adapted to each patient's genome.
Medical experts at Stanford and their colleagues at several other universities have raised ethical questions about the way a treatment for spinal muscular atrophy is being used.
Research has shown that better communication around assisted dying is needed between clinician and patients diagnosed with Huntington's disease. This is the first study in the UK (where assisted dying is illegal) into the attitudes of people with the condition, which usually leads to dementia and inability to coordinate movement. Because it is inherited, people with a diagnosis will often have witnessed the suffering of a parent.
The rationale for the Goldwater Rule -- which prohibits psychiatrists from publicly commenting on the mental health of public figures they have not examined in person -- does not hold up to current scientific scrutiny, a new analysis finds.
Research from the University of Warwick indicates that most people are in the UK are in favor of newborn screening for the potentially deadly condition spinal muscular atrophy (SMA).
The team of researchers behind a recent landmark study on predatory journals has now outlined the first concrete steps that stakeholders can take to combat the growing influence of these journals. Their recommendations focus on educating researchers, auditing publications, changing incentives at the institution and funder levels and applying pressure to stakeholders.
An international collaboration of researchers from Japan, Russia, Spain, and Australia has created the first genome-wide set of avian transcription start sites. Their data have been made available through the web-based, open-access, interactive DNA visualization system, ZENBU. ('Zenbu' means 'all' in Japanese.) The database and their CAGE-based TSS mapping method are expected to greatly facilitate research on the early development of amniotes, a group of vertebrate animals including the mammals, birds and reptiles.
Standard-of-care sprawl and clinician self-interest, health implications of ending DACA, questions about CAR-T gene therapy, and more in the (November-December 2017 issue.