A team of researchers in Japan developed a synthetic molecular code to script gene activation. The process, described in the Journal of the American Chemical Society, could help lead to future gene-based therapies for a wide array of diseases.
A study published by Brazilian researchers describes one of Xanthomonas citri's secretion systems and a signaling pathway that enhances its resistance against amoebae. Investigations might contribute for future forms of intervening and putting a stop on the development of X. citri, known for its persistency.
Chemist Vincent Rotello at UMass Amherst, with others at University College London, have developed a 'quick and robust' blood test that can detect liver damage before symptoms appear, offering what they hope is a significant advance in early detection of liver disease. Details appear in Advanced Materials. Their new method can detect liver fibrosis, the first stage of liver scarring that can lead to fatal disease if left unchecked, from a blood sample in 30-45 minutes.
When cells become stressed, they activate specific response patterns. Würzburg researchers have identified new details of these responses, which can help to get a better understanding of neurodegenerative diseases.
Hematopoietic Stem Cells (HSCs) give rise to blood and immune cells of the body, and are therefore essential for our survival. The group of Manuela Baccarini at the Max F. Perutz Laboratories, a joint venture of the University of Vienna and the Medical University of Vienna, has now shown how intracellular signalling can safeguard this delicate balance between activation and dormancy. Their results are published in the prominent journal Cell Stem Cell.
University of Illinois engineers built a 3D printer that offers a sweet solution to making detailed structures that commercial 3D printers can't: Rather than a layer-upon-layer solid shell, it produces a delicate network of thin ribbons of hardened isomalt, the type of sugar alcohol used to make throat lozenges. The water-soluble, biodegradable glassy sugar structures have multiple applications in biomedical engineering, cancer research and device manufacturing.
Depending on the lighting, the surface of appropriately crafted nanoparticles can change its topography. Researchers from the Institute of Physical Chemistry of the Polish Academy of Sciences have shown that the molecular mechanism they have designed makes it possible, by the use of light, to effectively uncover or hide catalyst molecules. The technique they present leads to qualitatively new possibilities to control the course of chemical reactions.
The question of the origin of life remains one of the oldest unanswered scientific questions. A team at the Technical University of Munich (TUM) has now shown for the first time that phase separation is an extremely efficient way of controlling the selection of chemical building blocks and providing advantages to certain molecules.
Antimicrobial resistance is on the rise worldwide. This is becoming a problem for infectious diseases like tuberculosis as there are only a few active substances available to combat such diseases. Pharmacists at Martin Luther University Halle-Wittenberg (MLU) have now found a way to increase the efficacy of a common tuberculosis agent while, at the same time, reducing resistance to it. The research group presents its latest developments in the international journal Molecules.
DNA, the carrier of genetic information, has become established as a highly useful building material in nanotechnology. One requirement in many applications is the controlled, switchable assembly of nanostructures. In the journal Angewandte Chemie, scientists have now introduced a new strategy for control through altering pH value. It is based on ethylenediamine, which only supports the assembly of DNA components in a neutral to acidic environment -- independent of the base sequences and without metal ions.