Scientists at Fujita Health University, Japan, have discovered how deficiencies of the IL-36Ra protein -- caused by mutations in the IL36RN gene -- delay wound healing via the flooding of the wound with several types of immune cells. However, by inhibiting the functioning of proteins and the signaling pathways involved in activating the immune system at a wound, this delay can be offset. These findings could aid efforts to develop ways of regulating wound healing in IL36RN mutation-related skin disorders.
The 8th International Skin Integrity and Infection Prevention Conference: Demystifying Wound Infection: Improving Patient Outcomes was redesigned into an online Wounds Week and has proved to be so successful it will most certainly happen again.
Through intricate experiments designed to account for sex-specific differences, scientists at Scripps Research have collaborated to zero-in on certain changes in the brain that may be responsible for driving alcohol abuse among people with PTSD. In studies with rodents, researchers found that males and females exhibit their own distinct symptoms and brain features of PTSD and alcohol use disorder. Such differences are not typically accounted for in laboratory-based studies yet could lead to more successful clinical treatments.
Researchers have validated a new radiolabeled molecule that can be used with imaging tests to accurately detect and characterize brain injury.
A sizable research consortium coordinated by NTNU and St. Olavs Hospital will analyse large amounts of MRI exam data from around the world. The data will help researchers gain important new understanding about brain injuries in people who have had trauma to the head. The goal is to improve patient health care.
Among women participating in cervical cancer screening in Sweden, those with a diagnosis of invasive cervical cancer had an increased risk of iatrogenic injuries (as a consequence of medical intervention) and non-iatrogenic injuries (caused by accidents and self-harm) requiring hospitalization.
NUST MISIS material scientists have presented antibacterial nano-coatings based on boron nitride, which are highly effective against microbial pathogens (up to 99.99%). They can become a safe alternative to the usual antibiotics in implantology since they do not have typical negative side effects. The results of the work are published in the international scientific journal ACS Applied Materials & Interfaces.
CVB announces findings from a study, led by Stanford University professor, Amit Etkin, MD, PhD, which generates new evidence in support of a critical brain imaging biomarker, that may guide people who suffer from PTSD or MDD towards the most effective treatment. The study used advanced machine learning techniques on data from high density EEG signals to identify robust and distinct functional connectivity patterns in brain circuits enabling subtyping of patients, independent of clinical diagnosis.
When looking at media reports in three cities, half of victims were covered in the news, but a disproportionate amount of attention was given to less common circumstances and victims.
A new study of gun injuries and deaths in Ontario found that 68% of firearm-related deaths were from self-harm, and they most often occurred in older men living in rural regions, pointing to the need for targeted prevention efforts. The study is published in CMAJ (Canadian Medical Association Journal) http://www.cmaj.ca/lookup/doi/10.1503/cmaj.200722.