Younger patients would benefit greatly from kidney transplantation. Their expected remaining lifetime may even be doubled by having a transplant. 'We have to do all we can to get young patients listed for transplantation as soon as possible, preferably pre-emptively', says Professor Luuk Hilbrands, Chair of the DESCARTES working group of the ERA-EDTA. A proposal for the work-up of low-risk kidney transplant candidates has now been published for that reason.
Researchers have developed a simple blood test that can detect when a newly transplanted lung is being rejected by a patient, even when no outward signs of the rejection are evident. The test could make it possible for doctors to intervene faster to prevent or slow down so-called chronic rejection -- which is severe, irreversible, and often deadly -- in those first critical months after lung transplantation.
The proportion of liver transplants in the United States for alcohol-associated liver disease increased between 2002 and 2016, with much of the increase associated with a decrease in liver transplant for hepatitis C virus infection because of antiviral therapy. This observational study used data from the United Network for Organ Sharing for all liver transplants during the 15-year period and the national study group consisted of nearly 33,000 patients, including 9,438 patients with a diagnosis of alcohol-associated liver disease.
The proportion of US liver transplants for alcohol-associated liver disease (ALD) has doubled in the last 15 years, in part due to broader acceptance of waiving the mandated period of sobriety before transplants for this population, according to a study by researchers at UC San Francisco, which showed ongoing regional geographic variations in liver transplant rates for ALD patients, whose long-term survival rate is slightly lower than other liver transplant patients. The study appears Jan. 22, 2019, in JAMA Internal Medicine.
Patients with lupus nephritis and end stage renal disease may benefit from timely kidney transplant, as transplantation was associated with a significant increase in survival in a nationwide cohort study. The main reason for the overall survival benefit was fewer deaths due to cardiovascular disease and infections. The findings are published in Annals of Internal Medicine.
Scientists at Newcastle University have developed a biological system which lets cells form a desired shape by molding their surrounding material -- in the first instance creating a self-curving cornea. The astonishing video shows the cornea molding itself into a bowl-like structure over the course of 5 days.
TNFα-induced cell death is tightly regulated and resisted in endothelial cells. Here, an Osaka University-led research team used a unique type of mouse, in which TAK1 could be deleted in specific tissues, to show that TAK1 is an essential component in ensuring survival of endothelial cells during inflammation and injury, and that TAK1 could be a novel target for anti-angiogenic therapy in cancer treatment.
Organ transplant rejection is a major problem in transplantation medicine. Suppressing the immune system to prevent organ rejection, however, opens the door to life-threatening infections. Researchers at the University of Basel's Biozentrum have now discovered a molecular approach preventing rejection of the transplanted graft while simultaneously maintaining the ability to fight against infections.
A team of scientists from the New York Stem Cell Foundation (NYSCF) Research Institute reported Friday in Stem Cell Research and Therapy that they have made valuable progress toward creating clinical-grade cells for treatment of bone disease and injury. In their study, the team identified two types of growth media that could support effective expansion of mesenchymal progenitor (MP) cells from stem cells in a clinically compatible, Good Manufacturing Practice (GMP) setting.
Children who receive solid organ transplants are hospitalized due to vaccine-preventable infections at rates that are significantly higher than the general population, according to a newly published study by University of Colorado School of Medicine researchers.