Fecal microbiota transplant (FMT), or the transfer of stool from a healthy donor to a patient, has been found effective in reversing severe, recurring diarrheal infections from Clostridiodes difficile in adults by restoring a normal microbiome. Now, the largest study to date of FMT in children finds the procedure to be safe and effective in eradicating an infection that is on the rise among children, even those without known risk factors.
Up to 1 in 7 kidney donors and recipients may have a type of genetic incompatibility that leads to organ rejection, researchers at Columbia University have found.
Islets transplanted within the anterior chamber of the eye may be reliable reporters of the early onset of autoimmunity in type 1 diabetes and help guide timely intervention to halt or delay its development, according to scientists from the Diabetes Research Institute at the University of Miami.
In a paper to be published in a forthcoming issue of TECHNOLOGY, a group of researchers from Harvard Medical School have done a study on the viability of donated livers and its correlation with donor demographics. The results of this study could reduce the number of livers that are discarded and facilitate development of novel therapeutics and bioengineering for clinical research applications.
After receiving a kidney transplant, children may experience worrisome quality-of-life changes that underscore the importance of screening transplant recipients for psychosocial function, according to Children's research presented during the 10th Congress of the International Pediatric Transplant Association.
Harvard University researchers used single-cell sequencing to identify a protein expressed uniquely by insulin-producing beta cells created from stem cells in the laboratory. By targeting the protein and adding a physical enrichment method developed by collaborators at Semma Therapeutics, the purity of beta cells improved from 30 to 80%. Improved control over the beta cell production process will allow researchers to refine cell therapy for patients with type 1 diabetes.
A new technique to rehabilitate lungs that are too damaged to be considered for transplant could benefit an increasing population of patients with end-stage lung disease.
Researchers have -- for the first time -- demonstrated in a clinically relevant model that severely damaged lungs can be regenerated to meet transplantation criteria. Their new study describes the cross-circulation platform that maintained the donor lung's viability and function and the recipient's stability for 36-56 hours. Current methodologies of lung support are limited to only 6-8 hours, a time too short for therapeutic interventions that could regenerate the injured lung and improve its function.
A new study shows that a potential treatment for ischemia- reperfusion injury is safe for humans.
Bioengineers have cleared a major hurdle on the path to 3D printing replacement organs. It's a breakthrough technique for bioprinting tissues with exquisitely entangled vascular networks that mimic the body's natural passageways for blood, air, lymph and other vital fluids.