Scientists demonstrate that Leishmania adaptation results from frequent and reversible chromosomal amplifications. This novel insight into Leishmania genomic instability should pave the way for the identification of parasite drug resistance mechanisms and help discover biomarkers.
A surprising discovery shows that a widely used and 20-year-old medicine used to treat multiple sclerosis can also beat a type of multi-resistant bacteria for which there are currently only a few effective drugs. The result may be of significance for the treatment of patients and in the battle against resistant bacteria.
For the first time, a research team from the Cell and Developmental Biology (Bosch AG) working group at the Zoological Institute at Kiel University (CAU) has been able to prove that the bacterial colonisation of the intestine plays an important role in controlling peristaltic functions. The scientists published their results yesterday -- derived from the example of freshwater polyps Hydra -- in the latest issue of Scientific Reports.
Scientists at Université de Montreal's Department of Biochemistry and Molecular Medicine design better molecules that make it harder for plasmids to move between bacteria.
Researchers at Duke University have discovered that reducing the use of antibiotics will not be enough to reverse the growing prevalence of antibiotic resistance because bacteria are able to share the ability to fight antibiotics by swapping genes between species. They also show, however, that there are ways to disrupt the gene-sharing process and perhaps reverse antibiotic resistance.
Using a real-world outbreak as a test case, a team combined patient-transfer data and whole-genome sequencing to identify hotspots for transmission of antibiotic-resistant bacteria.
In a new study, researchers demonstrate using a mouse model that engineered nanosponges can be used to protect eyes from infections caused by Enterococcus faecalis. Enterococcus faecalis contain a toxin called cytolysin, which is found in roughly 50 percent of isolates that cause post-operative intraocular infections seen in the United States.
Columbia University biologists have revealed a mechanism by which bacterial cells in crowded, oxygen-deprived environments access oxygen for energy production, ensuring survival of the cell. The finding could explain how some bacteria, such as Pseudomonas aeruginosa (P. aeruginosa), are able to thrive in oxygen-poor environments like biofilms and resist antibiotics. P. aeruginosa biofilm infections are a leading cause of death for people suffering from cystic fibrosis, a genetic condition that affects the lungs and the digestive system.
Three new research studies from the University of Texas at Arlington have found harmful pathogenic bacteria in Texas groundwater near unconventional natural gas extraction sites.
A properly functioning immune system is key to resolve bacterial pneumonia. Researchers from the University Children's Hospital Zurich and UZH working with an international team have now found that specific immune cells are crucial for recovery. The researchers' work paves the way for developing new vaccines, which would also counteract the emerging resistance to antibiotics.