An international team of researchers led by Cortexyme co-founders Stephen Dominy, M.D. and Casey Lynch detail the role of a common bacterium, Porphyromonas gingivalis (Pg), in driving Alzheimer's disease pathology and demonstrate the potential for small molecule inhibitors to block the pathogen.
Using a tool first used for strep throat in horses, Houston Methodist researchers unveiled the secret life of flesh-eating bacteria, learning how it causes severe disease while living deep within muscle. The team focused on necrotizing myositis. The study appears Jan. 22 in the Journal of Clinical Investigation. Corresponding author James M. Musser says his team now has an in-depth understanding of the precise genes group A streptococcus uses to cause this deadly infection.
Researchers at the UAB and the UMBC have described a new process capable of generating resistance to synthetic antibacterial drugs within bacterial populations long before their invention and without the existence of any similar substance in nature. The study has established that sulfonamide-resistant genes appeared million years ago thanks to a mutation in the drug's target gene.
Researchers from the Department of Biomedical Research of the University of Bern and the University Clinic of Visceral Surgery and Medicine of the Inselspital Bern, Switzerland, have discovered that changes in the composition of the intestinal bacteria in patients with chronic inflammatory bowel disease affect the severity of the disease and the success of therapy. The advance provides an important basis to improve treatment of these diseases.
Do laws of biodiversity also apply to our own bodies and homes? If so, current hygiene measures against aggressive germs could sometimes be counterproductive, writes an interdisciplinary research team from the German Centre for Integrative Biodiversity Research (iDiv) in Nature Ecology & Evolution. They propose to examine the role diversity of microorganisms plays in our domestic environment more intensively. The findings could challenge existing strategies for fighting infectious diseases and resistant germs.
You may have heard that your gut bacteria or 'microbiome' outnumbers your own cells -- but did you know that your microbiome ... has its own microbiome? Or that turning veggie can transform your microbiome in just 24 hours? How about scientists trialing poop transplants for diabetes? A new review in Frontiers in Cellular and Infection Microbiology reveals some surprising facts in its quest to discover: 'what makes a super pooper?'
Engineers have created a bacteria-filtering membrane using graphene oxide and bacterial nanocellulose. It's highly efficient, long-lasting and environmentally friendly -- and could provide clean water for those in need.
University of Otago research to better understand how bacteria and their viruses interact and evolve will enable future studies to exploit the use of bacteria and their viruses for potential biotechnology and health applications.
Researchers from North Carolina State University have developed an artificial enzymatic pathway for synthesizing isoprenoids, or terpenes, in E.coli. This shorter, more efficient, cost-effective and customizable pathway transforms E. coli into a factory that can produce terpenes for use in everything from cancer drugs to biofuels.
Fruit flies fed antibiotics to supress their gut microbiome are forced to avoid the best food patches if they lack vital amino acids, according to a study by Boaz Yuval from The Hebrew University of Jerusalem in Israel and Chang-Ying Nui from Huazhong Agricultural University in China, publishing Jan. 16, 2019, in the open-access journal PLOS ONE.