New study calls for human-based tools to unravel the pathogenesis of non-alcoholic steatohepatitis (NASH). The contribution of in silico, in vitro and pathways-based systems biology approaches to unraveling the pathogenesis of this disease are described, and how this human-relevant research can be used for anti-NASH drug development.
Getting parched can fuzz attentiveness and make it harder to solve problems. Dehydration can easily put a dent in those and other cognitive functions, a new metadata analysis of multiple studies shows. Researchers are particularly interested in accident potential this may pose for people who toil in the heat around heavy equipment or military hardware.
In a new study in mice, researchers have identified a key protein involved in the irregular brain cell activity seen in autism spectrum disorders and epilepsy. The protein, p53, is well-known in cancer biology as a tumor suppressor.
In a large international study involving almost 900,000 participants, researchers from the University of Copenhagen and COPSAC have found new risk genes for hay fever. It is the largest genetic study so far on this type of allergy, which affects millions of people around the world.
New research explains how some populations of bottlenose dolphins can dive to almost 1,000 meters while avoiding decompression sickness. The new hypothesis suggests that lung architecture and the management of blood flow allow bottlenose dolphins to access oxygen in the lungs while preventing uptake of nitrogen which would cause the bends. The findings act as a starting point to understand how environmental changes and anthropogenic interaction may impact the future of the species.
Numerous studies to date have shown that olfactory receptors are relevant not only for smell perception, but that they also play a significant physiological and pathophysiological role in all organs. An overview of receptors detected so far and of the functions they fulfil within the human body is provided by researchers from Ruhr-Universität Bochum, published in the journal Physiological Reviews;.
A team of University of Iowa researchers built a web-based app called MapTrek. When synced with a Fitbit, MapTrek allows users to go on virtual walking tours of locations such as the Grand Canyon or Appalachian trail while competing against other users. A study showed MapTrek and Fitbit users averaged 2,200 more steps per day than a control group that used only Fitbits.
Researchers at York University's Faculty of Health have found that patients who have metabolic healthy obesity, but no other metabolic risk factors, do not have an increased rate of mortality. The results of this study could impact how we think about obesity and health.
The muscles of people in intensive care are less able to use fats for energy, contributing to extensive loss of muscle mass, finds a new study co-led by UCL, King's College London and Guy's and St. Thomas' NHS Foundation Trust.
A review of more than 200 studies reveals that olfactory receptors -- proteins that bind to odors that aid the sense of smell -- perform a wide range of mostly unknown functions outside the nose. The function of extra-nasal olfactory receptors has the potential to be used in the diagnosis and treatment of health conditions such as cancer. The article is published in the July issue of Physiological Reviews.