In the international prospective multicenter crossover LEADER-75 trial, comparison of reduced-dose gadobutrol and standard-dose gadoterate versus unenhanced imaging demonstrated noninferiority using 20% margin for three primary efficacy measures; mean readings differed by less than 1%, supporting equivalence using a narrow ±5% margin. Various secondary variables also supported non-inferiority of reduced-dose gadobutrol.
Despite near unanimous objection from its advisory panel, the US Food and Drug Administration (FDA) granted aducanumab approval to treat Alzheimer's disease on June 7, 2021. In a commentary published in Annals of Internal Medicine, a member and former Chair of the advisory panel and an aducanumab site investigator explain why this unprecedented "accelerated approval" is problematic for clinical research and patient care.
A study performed by researchers at the Institute for Advanced Chemistry of Catalonia (IQAC-CSIC) from the Spanish National Research Council (CSIC) in collaboration with Stony Brook University (USA) proposes a new strategy for the development of new drugs based on the inhibition of tyrosine kinase enzymes, molecules that activate and trigger many cellular processes. The results have been published in the Chemistry - A European Journal.
Scientists are already preparing for a possible next coronavirus pandemic to strike, keeping with the seven-year pattern since 2004. In future-looking research, scientists have identified a novel target for a drug to treat SARS-CoV-2 that also could impact a new emerging coronavirus. "God forbid we need this, but we will be ready," said the lead Northwestern scientist.
The accumulation of micro- and nanoplastics in the environment continues at an alarming rate. A radiolabelling technique developed at the University of Helsinki made it possible to monitor the movement and accumulation of plastics in the mouse body, as well as their elimination from it.
A new model that applies artificial intelligence to carbohydrates improves the understanding of the infection process and could help predict which viruses are likely to spread from animals to humans. This is reported in a recent study led by researchers at the University of Gothenburg.
Research by Oregon State University suggests a pair of compounds originating from hops can help thwart a dangerous buildup of fat in the liver known as hepatic steatosis.
In the first study to validate conflicting theories, a University of Houston researcher has confirmed that the zinc actually does inhibit and promote the growth of kidney stones at the same time.
Artemisone is a promising substance in the fight against malaria. However, the active ingredient has yet to be used due its instability and because it is not easily absorbed by the body. A team from Martin Luther University Halle-Wittenberg (MLU) and the Hebrew University of Jerusalem has now pushed this a bit further. They have developed a very simple method for preparing the active ingredient that makes it easier to administer and store.
Scientists have developed polypeptide-based materials that act as effective vectors for delivering gene therapies. The first-of-its-kind platform enables the vectors to be adapted to suit the specific gene therapy cargo.