MIT researchers have designed an ingestible capsule that can be controlled using Bluetooth wireless technology. Their capsule, which can be customized to deliver drugs, sense environmental conditions, or a combination of those functions, can reside in the stomach for at least a month, transmitting information and responding to instructions from a user's smartphone.
A new study published ahead-of-print by SLAS Discovery describes an evaluation of microplate-based high-throughput cellular thermal shift assay (CETSA HT) performed at AstraZeneca to assess its suitability and reliability for application to early drug discovery campaigns.
Louis Populin and collaborators at the University of Wisconsin-Madison collaborators published a study this week in the Journal of Neuroscience describing increased connections between key parts of the brains of monkeys who have taken methylphenidate (Ritalin).
The major degradation products of pralatrexate drug product formed under hydrolytic and light stress conditions were identified, synthesized and characterized using advanced spectroscopic techniques such as NMR, HR-MS and IR.
An international team has developed a novel pharmaceutical formulation to administer triclabendazole -- an anti-parasitic drug used to treat a type of flatworm infection -- in billions of tiny capsules.
Like people in a large company, proteins in cells constantly interact with each other to perform various jobs. To develop new disease therapies, researchers are trying to control these interactions with small-molecule drugs that cause specific proteins to associate more or less with their 'coworkers.' Now, researchers reporting in ACS' journal Analytical Chemistry have developed a method to visualize whether drugs are regulating protein-protein interactions inside cells.
It costs the global economy an estimated US $2 trillion annually and has been dubbed a modern day health epidemic, but new research from the University of South Australia has unearthed a possible cure for obesity -- and it is as plain as dirt!
Portland State University researchers have made a significant breakthrough by developing the 3D structure of proteins from inside the eye lens that control how cells communicate with each other, which could open the door to treating diseases such as cataracts, stroke and cancer
Dangerous antibiotic-resistant bacteria could soon be targeted with a drug initially developed to treat Alzheimer's disease. University of Queensland-led research investigated the antibacterial properties of metal transport drug, PBT2.
Patients with albuminuria will usually need more than one drug to achieve blood pressure control, particularly if the aim is also to reduce albuminuria.