A new study reveals that the common asthma drug salbutamol may offer potential as a treatment for Alzheimer's disease.
The synthesis of silica particles, used in bioimaging and drug delivery, could become considerably cheaper and more efficient by adopting a new flow synthesis method demonstrated by researchers in Australia and China, which involves a spiral channel and simple Teflon pipe to promote the rapid mixing of precursor fluids.
A quality improvement initiative in the Neonatal Intensive Care Unit (NICU) at Children's National Hospital led to a significant reduction in treatment with intravenous vancomycin, an antibiotic used for resistant gram positive infections, which is often associated with acute kidney injury. The findings, published in the journal Pediatrics, show the initiative reduceed vancomycin use in patients by 66%, and the NICU has sustained the reduction for more than a year.
Scientists at The University of Tokyo and Fudan University researched the process of crystallization in which competing structural forms coexist. By compensating for fluctuations, they were able to more accurately describe the process that determines the final crystalline form. This work may help industrial chemists design new methods.
Experiments in mice have shown early success in vaccinating them against potentially deadly bacterial infections, such as methicillin-resistant Staphylococcal aureus, or MRSA, the strain resistant to most drug treatments.
In a new study, scientists at Gwangju Institute of Science and Technology developed novel ligand molecules, which facilitate a catalytic reaction that generates useful compounds called chromanones. Chromanones, which have a stereocenter at C2 position (such as gonytolides C and lachnone C), are prominent structural motifs in natural products and possess numerous bioactivities. The newly synthesized ligand molecules offer an effective strategy for generation of chromanones, opening doors to a myriad of applications in drug design.
CAR-T therapy has been used successfully in patients with blood cancers such as lymphoma and leukemia. It modifies a patient's own T-cells by adding a piece of an antibody that recognizes unique features on the surface of cancer cells. In a new study, researchers report that they have dramatically broadened the potential targets of this approach - their engineered T-cells attack a variety of solid-tumor cancer cells from humans and mice.
A joint research team from POSTECH and Japan's Shinshu University evaluates the filtration efficiency of nanofiber and melt-blown filters when cleaned with ethanol.
Prof. QU Xiaogang from the Changchun Institute of Applied Chemistry (CIAC) of the Chinese Academy of Sciences and his colleagues recently presented a novel strategy using a neutrophil-directed ATH reaction to achieve site-selective chiral drug synthesis in living systems.
In a step toward better control of the mosquitoes that transmit malaria, researchers have mapped the patterns of insecticide resistance in Anopheles gambiae mosquitoes across Africa. The new study, published June 25, 2020 in the open-access journal PLOS Biology by Catherine Moyes and Penelope Hancock of the University of Oxford, UK, and collaborators, found that resistance to five mainstream insecticides increased dramatically between 2005 and 2017.