A multidisciplinary team of researchers from the National University of Singapore has developed an artificial intelligence technology platform that could potentially change the way drug combinations are being designed, hence enabling doctors to determine the most effective drug combination for a patient quickly.
In tests with mice and in vivo culture, molecule designed in Brazil was capable of killing Plasmodium resistant strains and reducing the number of parasites in the bloodstream by 62 percent without attacking cells of the host organism.
A group of Japanese researchers has developed a technology to create a hybrid catalyst from simple-structured, commercially available rhodium and organic catalysts, which reduces chemical waste and produces molecules with high selectivity of an enantiomer, a pair of molecular structures that are non-superimposable mirror images of each other. This technology is expected to assist in rapid and low-cost drug synthesis.
The method could speed the discovery of new drugs and other products by offering the ability to simply and efficiently build a wide variety of molecular architectures.
Researchers at University of Utah Health developed a proof-of-concept technology using nanoparticles that could offer a new approach for oral medications.
Nanoparticles show great promise as diagnostic tools and drug delivery agents. The tiny particles, which scientists can modify with drugs, dyes or targeting molecules, can travel in the circulation and squeeze through small spaces into cells and tissues. But until now, most nanoparticles had to be injected into the bloodstream because they weren't absorbed well orally. Now, researchers reporting in ACS Nano have modified nanoparticles to improve their uptake in the gastrointestinal tract.
In this month's issue of the Journal of Lipid Research, researchers report the structure of a key long-chain lipid in the tear film lipid layer, which prevents tears from drying out. Their finding may be used to improve treatments for dry eye.
Now, scientists at Scripps Research and Bristol-Myers Squibb have created a powerful new tool for precisely controlling the 3D architecture -- also called stereochemistry -- of linkages known as thiophosphates, found in some promising new drugs that target genetic molecules and other disease targets, according to a paper published today in Science.
Scientists have discovered that curcumin to be an effective agent for killing cancer cells. Curcumin's effective has been extremely limited because it isn't natually soluble in water. Recently, however a team led by Dipanjan Pan, a professor of bioengineering, has created a sophisticated metallocyclic complex using platinum that has not only enabled curcumin's solubility, but whose synergy has proven 100 times more effective in treating various cancer types such as melanoma and breast cancer cells than using curcumin and platinum agents separately.
In metastatic breast cancer, prognosis and treatment is largely influenced by estrogen receptor (ER) expression of the metastases. However, little is known about ER expression across metastases throughout the body and surrounding normal tissue. Using a PET tracer, researchers in the Netherlands have been able to identify differences in ER expression, which could help guide treatment for metastatic breast cancer patients. The study is featured in The Journal of Nuclear Medicine's August issue.