Geneticists have assembled the largest sets of African genomic data available to date, creating a resource that will help researchers understand the genetic structure of Africa as well as the effects of genetic variation on protein function and disease. The findings underscore the importance of including globally diverse participant cohorts in genetics research, and were presented in a plenary session at the American Society of Human Genetics (ASHG) 2018 Annual Meeting in San Diego, Calif.
By studying the effect of genetic variations on lifespan across the human genome, researchers have devised a way to estimate whether an individual can expect to live longer or shorter than average, and have advanced scientific understanding of the diseases and cellular pathways involved in aging. Their findings were presented at the American Society of Human Genetics (ASHG) 2018 Annual Meeting in San Diego, Calif.
UTA researchers set out to determine whether pythons could have adapted to an extreme Florida freeze event in 2010. They generated data for dozens of samples before and after the freeze event. By scanning regions of the Burmese python genome, they identified parts of the genome that changed significantly between the two time periods, providing clear evidence of evolution occurring over a very short time scale in this population.
Mount Sinai Scientists developed a novel way to barcode and track different CRISPRs by utilizing synthetic proteins built from combinations of smaller proteins, called epitopes. By being able to mark each CRISPR with a unique identifier, the protein barcodes, or Pro-Codes for short, enable hundreds of CRISPRs to be used together to knockout a multitude of genes.
Michigan State University researchers have improved an introductory biology class to make it more accessible for students not majoring in life sciences. The new course, 'Integrative Biology: From DNA to Populations,' features Avida-ED, a digital evolution software program that allows populations of digital organisms, aka Avidians, to undergo actual, not simulated, evolutionary change.
In new studies conducted at UC San Francisco, a novel oxygen-delivery therapeutic restored the function of oxygen-starved heart tissue in an animal model of global hypoxia. Unlike its experimental predecessors, the new drug does not appear to cause systemic side effects or overcorrect with excessive blood oxygenation, which can itself be toxic. Instead, the new drug delivers its precious oxygen cargo only to the tissues that need it most.
People who have better spatial memory are also better at identifying odors, according to a study published this week in Nature Communications. The study builds on a recent theory that the main reason that a sense of smell evolved was to aid in navigation, since most animals rely primarily on smell to find food and avoid predators.
A new Florida State University College of Medicine study in mice produced results that suggest nicotine exposure in men could lead to cognitive deficits in their children and grandchildren. Further studies will be required to know if the same outcomes seen in mice would apply to humans.
In a recent study published in Landscape Ecology, University of Illinois researchers and others found that a common cattle forage grass, tall fescue, is associated with nest failure in dickcissels, small grassland birds similar to sparrows.
Researchers have taken advantage of the benefits of DNA immunization over traditional protein-based immunization to elicit monoclonal antibodies (mAbs) against challenging targets in three species -- mouse, rabbit, and human models.