A team of neuroscientists and engineers at McMaster University has created a nasal spray to deliver antipsychotic medication directly to the brain instead of having it pass through the body.
The newly published review 'Analytical considerations and plans to standardize or harmonize assays for the reference bone turnover markers PINP and β-CTX in blood' describes the current status of assays for PINP and β-CTX in blood, as well as the plans for and ongoing progress towards the achievement of harmonization or standardization of commercial assays for these reference markers.
Use of the diabetes drug metformin -- before a diagnosis of COVID-19 -- is associated with a threefold decrease in mortality in COVID-19 patients with Type 2 diabetes, according to a racially diverse study at the University of Alabama at Birmingham. Diabetes is a significant comorbidity for COVID-19. This beneficial effect remained, even after correcting for age, sex, race, obesity, and hypertension or chronic kidney disease and heart failure.
A breakthrough that has implications for molecular biology, pharmacology and nanotechnologies. The fields of application are many. Identifying the mechanisms behind neurodegenerative processes in some proteins, for example, can help limit their proliferation. Understanding how a protein takes on a certain shape can open the way to use the nanomachines that nature has designed to cut, edit or block damaged or defective genes. Their study was published in the international academic journal Physical Review Letters
As a new, apparently more transmissible version of the virus that causes COVID-19 has appeared in several countries, new research finds that the transmissibility of viral strains and the population density of a region will play big roles in how vaccination campaigns can help towns and cities return to more normal activities. The findings suggest that directing vaccines toward densely populated counties would help to interrupt transmission of the disease.
Researchers at the Technion - Israel Institute of Technology and the European Molecular Biology Laboratory in Hamburg have discovered remarkable molecular properties of an antimicrobial peptide from the skin of the Australian toadlet. The discovery could inspire the development of novel synthetic drugs to combat bacterial infections
Researchers at Baylor College of Medicine have discovered how therapeutics targeting RNA splicing can activate antiviral immune pathways in triple negative breast cancers (TNBC) to trigger tumor cell death and signal the body's immune response.
A compound developed at Oregon Health & Science University appears to protect nerve fibers and the fatty sheath, called myelin, that covers nerve cells in the brain and spinal cord. The new research in a mouse model advances earlier work to develop the compound - known as sobetirome - that has already showed promise in stimulating the repair of myelin.
Primary amoebic meningoencephalitis (PAM), a deadly disease caused by the "brain-eating amoeba" Naegleria fowleri, is becoming more common in some areas of the world, and it has no effective treatment. Now, researchers reporting in ACS Chemical Neuroscience have found that a compound isolated from the leaves of a traditional medicinal plant, Inula viscosa or "false yellowhead," kills the amoebae by causing them to commit cell suicide in lab studies, which could lead to new treatments.
A team of researchers co-led by Berkeley Lab and Columbia University has developed a new material called avalanching nanoparticles that, when used as a microscopic probe, offers a simpler approach to taking high-resolution, real-time snapshots of a cell's inner workings at the nanoscale.