Experiments with mice suggest that treatment with atorvastatin can attenuate adipose tissue remodeling, leading to rapid weight loss and muscle atrophy.
Researchers at Eindhoven University of Technology and Utrecht University have discovered the parameters that govern the encapsulation of drugs. This gives more control over the slow and steady release of drugs in patients. Moreover, designing encapsulations for new drugs will now require far less experimentation which makes for faster and cheaper drug development. The researchers believe this work will have a significant impact on the biomedical field and designing future drugs.
By suppressing the activity of key cellular receptors called G protein-coupled receptors (GPCRs) and their interacting partners called G proteins, statins have the potential to alter various bodily functions controlled by this important pathway, according to researchers at The University of Toledo.
Common medications prescribed to treat heartburn, acid reflux and ulcers are linked to increased risks for kidney failure and chronic kidney disease, found a recent University at Buffalo study.
Most nonpharmacologic and pharmacologic interventions are more likely than no treatment to improve outcomes for women with either stress or urgency urinary incontinence (UI). Behavioral therapy, alone or in combination with other interventions, was found to be generally more effective than pharmacologic therapies alone. Findings from a systematic evidence review and network meta-analysis of clinical outcomes of nonpharmacologic and pharmacologic interventions for UI are published in Annals of Internal Medicine.
Study finds that performing catheter ablations on patients who suffer from both atrial fibrillation and carotid arterial disease reduces their risk of dementia and stroke compared to managing their care with medications.
Study finds that taking statins for heart disease cuts risk of second serious event in half, yet only 6 percent of patients are following as directed.
University of Cincinnati professor Jason Heikenfeld and his students have been creating new sensors on a wearable patch the size of a Band-Aid that stimulates sweat even when a patient is cool and resting. The sensor measures specific analytes over time that doctors can use to determine how the patient is responding to a drug treatment.
Dysregulation of the signaling pathway known as the beta-catenin-dependent Wnt can also cause embryo malformation and contribute for the development of breast and cervical cancer.
National and state trends for opioid prescriptions filled at US retail pharmacies are estimated from 2006 through 2017 in this analysis of data from outpatient prescribing records. Each year an average of nearly 234 million opioid prescriptions were filled. Several key measures of opioid prescribing varied among states.