A stealthy new drug-delivery system disguises chemotherapeutics as fat in order to outsmart, penetrate and destroy tumors. Thinking the drugs are tasty fats, tumors invite the drug inside. Once there, the targeted drug activates, immediately suppressing tumor growth.
Scientists at Berkeley Lab have made a new material that is both liquid and magnetic, opening the door to a new area of science in magnetic soft matter. The new material could lead to a revolutionary class of printable liquid devices for a variety of applications from artificial cells that deliver targeted cancer therapies to flexible liquid robots that can change their shape to adapt to their surroundings.
In a new publication in Nature, University of Utah chemists Jolene Reid and Matthew Sigman show how analyzing previously published chemical reaction data can predict how hypothetical reactions may proceed, narrowing the range of conditions chemists need to explore. Their algorithmic prediction process, which includes aspects of machine learning, can save valuable time and resources in chemical research.
Rutgers researchers have created a device that can determine whether targeted chemotherapy drugs are working on individual cancer patients. The portable device, which uses artificial intelligence and biosensors, is up to 95.9% accurate in counting live cancer cells when they pass through electrodes, according to a study in the journal Microsystems & Nanoengineering.
A new computational tool developed in the lab of USC Viterbi School Ming Hsieh Department of Electrical and Computer Engineering professor Paul Bodgan in collaboration with Ming Hsieh professor Edmond Jonckheere, is able to quickly identify the hidden affiliations and interrelationships among groups/items/persons with greater accuracy than existing tools.
Scientists created human pancreas on a chip that allowed them to identify the possible cause of a frequent and deadly complication of cystic fibrosis (CF) called CF-Related Diabetes, or CFRD. It may be feasible to also use the small two-chambered device, which features bioengineered human pancreatic organoids to study the causes of non-CF-related conditions such as type 1 and 2 diabetes, according to researchers who report findings in Nature Communications.
Penguins, Asian elephants and many other animal species live in the zoos of Saarbrücken and Neunkirchen. As they come from different continents, blood is regularly taken from the animals to check their health. These blood samples have now been used by bioinformaticians and human geneticists at Saarland University to search for biomarkers with which diseases can be detected at an early stage.
Preventing a protein from doing its job may keep a certain type of ovarian cancer cell from growing and dividing uncontrollably in the lab, according to a new study from Penn State College of Medicine.
A dysfunctional enzyme involved in building cancer cell membranes helps fuel tumor growth; when it's disabled or depleted in mouse models, tumors shrank significantly.
Scientists have discovered a novel mechanism and role in the brain for hyaluronic acid -- a clear, gooey substance popularized by cosmetic and skin care products. Hyaluronic acid may be the key in how an immune signal moves from the blood stream to the brain, activating the brain's resident immune cells, the microglia. Findings from this study have important implications for better treatments for stroke, neurodegenerative diseases, as well as head injuries.