Chemist Vincent Rotello at UMass Amherst, with others at University College London, have developed a 'quick and robust' blood test that can detect liver damage before symptoms appear, offering what they hope is a significant advance in early detection of liver disease. Details appear in Advanced Materials. Their new method can detect liver fibrosis, the first stage of liver scarring that can lead to fatal disease if left unchecked, from a blood sample in 30-45 minutes.
p38 blockage has been shown to increase the death of tumor cells, thus causing tumors to shrink. The combination of p38 inhibitors with chemotherapeutic drugs (taxanes) strengthens, accelerates or prolongs the antitumor effect in patient-derived tumors grown in mice.
Some examples of the persistence of incompletely resolved issues in asthma management are: 1) misdiagnosis -- with the related complex consequences --, especially in children population and, 2) poor control of the disease. Also related factors as suboptimal medical management , poor education and health literacy of patients, poor adherence and elevated costs for patients and healthcare systems are some other factors that need urgent implementation.
The question of the origin of life remains one of the oldest unanswered scientific questions. A team at the Technical University of Munich (TUM) has now shown for the first time that phase separation is an extremely efficient way of controlling the selection of chemical building blocks and providing advantages to certain molecules.
Addressing a critical issue for people with a genetic disorder called tuberous sclerosis complex (TSC), doctors at The University of Texas Health Science Center at Houston (UTHealth) reported that a skin cream containing rapamycin significantly reduced the disfiguring facial tumors affecting more than 90 percent of people with the condition.
A new Tel Aviv University study identifies a previously unknown mechanism involved in the development of Lou Gehrig's disease, or amyotrophic lateral sclerosis (ALS). The findings could serve as the foundation for the treatment of ALS in the future.
Antimicrobial resistance is on the rise worldwide. This is becoming a problem for infectious diseases like tuberculosis as there are only a few active substances available to combat such diseases. Pharmacists at Martin Luther University Halle-Wittenberg (MLU) have now found a way to increase the efficacy of a common tuberculosis agent while, at the same time, reducing resistance to it. The research group presents its latest developments in the international journal Molecules.
Researchers at King's College London have found that patients prescribed any of the 12 most commonly used antidepressants were 21 percent more likely to experience an episode of gain weight than those not taking the drugs, (after adjusting for other factors which might affect this result).
Prescription cough and cold medicines containing the opioid hydrocodone were more likely to cause serious side effects in children than those containing codeine, according to a new study from Penn State College of Medicine. The research supports recent U.S. Food and Drug Administration (FDA) restrictions on prescription hydrocodone- and codeine-containing cough medicines for children and suggests that opioids in general should not be prescribed for coughs and colds in pediatric populations.
A non-surgical procedure, called percutaneous coronary intervention (PCI), along with prescribed medication, is better than medication alone as initial treatment for people who have the most common form of heart disease, suggests an analysis of an international clinical trial co-led by St. Michael's Hospital.