Researchers from University of Tsukuba, in collaboration with scientists in Germany, have created a mouse model of restrictive cardiomyopathy, a disease in which the heart muscle becomes stiff and the heart is unable to properly fill with blood. Their data suggest that the disease results from the accumulation of mutant BAG3 protein, which interferes with the protein quality control system and the machinery for breaking down and recycling damaged proteins, disrupting the heart muscle components.
The information presented in this study is primarily positioned to benefit scientists and experts in Cellular Physiology and Histochemistry where new tools to discover therapeutic targets for muscle atrophy are needed. The study outlines the development of a new fluorescent reporter mouse line to detect changes in mitophagy activity. These findings could revolutionize treatment strategies and possibly facilitate interventions to reverse disuse-induced muscle atrophy.
What The Study Did: This autopsy study examines differences in skeletal muscle and myocardial inflammation in patients who died with COVID-19 versus other diseases.
New research reveals that only a minority of U.S. Medicare beneficiaries with knee osteoarthritis in 2005-2010 used non-surgical care such as physical therapy and knee injections, and few were treated by rheumatologists, physiatrists, or pain specialists. The study, which is published in Arthritis & Rheumatology, also found that non-surgical care was more common in regions with low rates of knee replacement surgery.
A study published in Arthritis Care & Research has uncovered an elevated risk of Parkinson's disease in individuals with osteoarthritis.
According to a pilot study published in ARRS' American Journal of Roentgenology, the flexed elbow valgus external rotation (FEVER) view can improve MRI evaluation of the ulnar collateral ligament (UCL) in Major League Baseball pitchers. The increased joint space width confirms elbow valgus stress with FEVER view. Diagnostic confidence increased, and additional UCLs were identified as abnormal.
The network connection between nerve cells in the spinal cord seems to play a critical role in the development of the severe disease ALS, a new study from the University of Copenhagen suggests. The study, which is based on a mouse model, may change the way we think about the disease, says researchers.
Engineering researchers from Aarhus University have developed electronic support stockings and tested them on 16 bed-ridden Covid-19 patients at Copenhagen University Hospitals, Bispebjerg and Herlev. The experiments show that the stockings counteract a significant loss of muscle mass.
By applying mass spectrometry, scientists at the University of Copenhagen provide some of the most detailed data on how mitochondrial proteins cluster into supercomplexes - a process that makes mitochondria more efficient at producing energy. The findings, which were published in Cell Reports, is a precious resource for the scientific community, especially those tackling mitochondrial adaptations to exercise training or mitochondrial diseases.
A group of researchers led by Tomohide Takaya of Shinshu University succeeded in improving skeletal muscle differentiation worsened by diabetes with oligo DNA.