Researchers at Duke University have shown that a single systemic treatment using CRISPR genome editing technology can safely and stably correct a genetic disease -- Duchenne muscular dystrophy (DMD) -- for more than a year in mice, despite observed immune responses and alternative gene editing outcomes.
Support from managers and colleagues, as well as a positive attitude, are most likely to enable a more long-term return to work for employees after a sickness absence, according to a new review of research led by the University of East Anglia (UEA). The review evaluated the impact of personal and social factors on sustainable return to work after ill-health due to musculoskeletal disorders, such as joint and back pain, and common mental health conditions, for example stress, depression or anxiety.
After reviewing thousands of case studies going back 25 years across six countries, generalisable survival data is now available for the first time to estimate how long hip and knee replacements are likely to last.
We use our wrists constantly, but how do they work? In a just-published Journal of Biomechanics article, UC Davis researchers proved a longtime assumption about individuals' right and left wrists, while also finding differences between wrists of males and females: discoveries that could help inform and guide future treatments.
Prednisone, the current standard of care used to treat kids with Duchenne muscular dystrophy (DMD), reduces chronic inflammation but has harsh side effects. Eplerenone, a heart failure drug, is used in older patients to treat cardiomyopathy, a leading cause of mortality for people with DMD. A new medicine under development appears to combine the beneficial effects of these drugs for the heart and muscle while also showing improved safety in experimental models.
A new British Journal of Clinical Pharmacology review examines the impact of cancer therapies on the skeleton and how to limit bone loss and fractures in cancer patients treated with these therapies.
The authors assess the effect of a mandatory educational program and new institutional prescriber guidelines on the behavior of physicians who prescribe opioid medications following lumbar surgery.
The authors describe how the modern golfer repeatedly experiences minor traumatic injuries to the spine, which over time can result in a pathogenic process termed 'repetitive traumatic discopathy.'
Radiologists may play a crucial role in identifying signs of intimate partner violence, a type of domestic violence, according to a new study. Radiologists can identify potential violence-related patterns of injury and work closely with referring providers to provide care for the victims.
Muscle co-contraction is a strategy used commonly in elderly people to increase their stability. Co-contraction involves the simultaneous contraction of pairs of muscles from opposing groups to lock a joint and provide stability.