Individuals taking a class of steroid hormones called glucocorticoids for conditions such as asthma, allergies and arthritis on a routine basis may be unable to mount a normal stress response and are at high risk if they are infected with the virus causing COVID-19, according to a new editorial published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism.
In older individuals, the location of a broken bone can have significant impacts on long-term health outcomes, according to research accepted for presentation at ENDO 2020, the Endocrine Society's annual meeting, and publication in a special supplemental section of the Journal of the Endocrine Society.
Exercise can only improve strength in muscle-degenerating diseases when a specific type of muscle cell ages, report a Hokkaido University researcher and colleagues with Sapporo Medical University in Japan. Their findings utilizing mice models were published in the journal Nature Communications.
High-force, high-repetition movements create microinjuries in muscle fibers. Muscle tissue responds by making repairs. But over time, with repetition of injury, healing capacity becomes overwhelmed, and microinjuries progress to fibrosis. Fibrosis weakens muscles and can put pressure on nerves, causing pain. Long thought to be irreversible, new research by Lewis Katz School of Medicine scientists shows for the first time in animals that it may be possible to undo fibrotic damage and restore muscle strength.
In Japan, an increase in the aging population has exacerbated the demand for regenerative medicine to address increasingly common diseases, such as knee osteoarthritis. In a new study, scientists from Tokyo University of Science, led by Prof Hidenori Otsuka, have developed a novel biocompatible hydrogel that acts as a structural scaffold for the growth of cartilage-producing cells, showcasing a promising new tool for tissue regeneration.
Artificial intelligence that can 'read' electronic radiology reports and flag patients with broken bones who are at risk of osteoporosis outperformed the traditional manual method of health care professionals reading X-ray reports, a new study finds. The results were accepted for presentation at ENDO 2020, the Endocrine Society's annual meeting, and will be published in a special supplemental section of the Journal of the Endocrine Society.
An experimental model of severe Duchenne muscular dystrophy that experiences a large spike in TGFβ activity after muscle injury shows that high TGFβ activity suppresses muscle regeneration and promotes fibroadipogenic progenitors, Children's National Hospital researchers find.
A study from Boston Children's Hospital used CRISPR-Cas9 to better understand facioscapulohumeral muscular dystrophy (FSHD) and explore potential treatments by systematically deleting every gene in the genome. Several 'hits' enabled muscle cells to stay alive and revealed pathways that could potentially be targeted with drugs.
Lithuanian scientists have devised a spinal stabilization exercise program for managing lower back pain for people who perform a sedentary job. After testing the program with 70 volunteers, the researchers have found that the exercises are not only efficient in diminishing the non-specific lower back pain, but their effect lasts 3 times longer than that of a usual muscle strengthening exercise program.
For patients with fragility fractures related to underlying bone weakness, a dedicated fracture liaison service (FLS) can lower the risk of subsequent fractures, suggests a study in the March 18, 2020 issue of The Journal of Bone & Joint Surgery. The journal is published in the Lippincott portfolio in partnership with Wolters Kluwer.