A team of scientists from Sechenov First Moscow State Medical University (MSMU) together with their colleagues from leading scientific centers of Moscow and India described a number of genetic mutations causing Usher syndrome (inherited deaf-blindness). They found previously unstudied unique mutations in investigated DNA regions. The results of the study were published in the Ophthalmic Genetics journal.
A new study, published in Clinical Epigenetics, identifies genes associated with Age-related Macular Degeneration (AMD) that could represent new targets for future drug development.
A signaling pathway controlled by transforming growth factor beta (TGF-beta) could be involved in the progression of age-related macular degeneration (AMD).
Scientists at Newcastle University have developed a biological system which lets cells form a desired shape by molding their surrounding material -- in the first instance creating a self-curving cornea. The astonishing video shows the cornea molding itself into a bowl-like structure over the course of 5 days.
Knowing precisely where the signals meet and the brain processes them is vital to treating amblyopia, or reduced vision in one eye because the brain and eye aren't working together properly.
Using a novel patient-specific stem cell-based therapy, researchers at the National Eye Institute (NEI) prevented blindness in animal models of geographic atrophy, the advanced 'dry' form of age-related macular degeneration (AMD), which is a leading cause of vision loss among people age 65 and older. The protocols established by the animal study set the stage for a first-in-human clinical trial testing the therapy in people with geographic atrophy, for which there is currently no treatment.
A clot in the retinal vein can lead to severe and irreversible loss of vision. In a report in The American Journal of Pathology investigators utilize a newly developed model of central retinal vein occlusion (CRVO) in mice that mimics many of the clinical features of CRVO in humans to study the pathologic effects of retinal occlusion and demonstrate the retinoprotective effects of the peptide adrenomedullin (ADM) and its receptor activity-modifying protein RAMP2.
New research from the University of East Anglia (UK) uses an improved laboratory model to simulate cataract surgery on human donor eyes. During cataract surgery, the eye's cloudy natural lens is removed and replaced with an artificial intraocular lens (IOL). The research team's latest human model allows evaluation of IOL implants under conditions that mimic the inflammation that patients experience after cataract surgery. It is hoped that the model will aid the development of next generation lenses.
Although currently laser surgery is a very popular tool for various vision disorders correction, it is still difficult to ensure proper control over the accuracy, efficiency and safety of such procedures. Therefore, Russian scientists proposed a new method that helps to describe tissue changes after such operations. This method was described in a series of publications in the Journal of Biophotonics, Journal of Biomedical Optics and Laser Physics Letters.
Single lens eyes, like those in humans and many other animals, can create sharp images, but the compound eyes of insects and crustaceans have an edge when it comes to peripheral vision, light sensitivity and motion detection. That's why scientists are developing artificial compound eyes to give sight to autonomous vehicles and robots, among other applications. Now, a report in ACS Nano describes the preparation of bioinspired artificial compound eyes using a simple low-cost approach.