Leaks in the blood-brain barrier can provide early detection for Alzheimer's and diseases.
While human genetic mutations are involved in a small number of Parkinson's disease (PD) cases, the vast majority of cases are of unknown environmental causes, prompting enormous interest in identifying environmental risk factors involved.
Non-motor symptoms are common in late stage Parkinson's disease (PD) as the frequency and severity of most of these symptoms increase with advancing disease. Optimizing dopaminergic treatment in the most severe stages can affect non-motor symptoms and improve quality of life, report scientists in the Journal of Parkinson's Disease.
New paper calls for the use of advances human-relevant methods to enable understanding of the initiation and progression of Parkinson's disease.
Using a new technique known as laser-capture RNA seq, that involves cutting out dopamine neurons from a human brain section with a laser, investigators from Brigham and Women's Hospital and Harvard Medical School have cataloged more than 70,000 novel elements active in these brain cells. Their results are published this week in Nature Neuroscience.
The vessels appear to carry previously unknown messages from the brain to the immune system that ultimately cause the disease symptoms. Blocking those messages may offer doctors a new way to treat a potentially devastating condition that affects more than 2 million people.
Astrocytes important role in brain function suggests they are also involved in disease. Now, scientists at Sanford Burnham Prebys Medical Discovery Institute (SBP) have identified an astrocyte subpopulation as the dominant cell type to spring into action in vivo (in a living organism) in a neuroinflammatory disease setting. Their early activation inspired their new name: ieAstrocytes (immediate early astrocytes). The study published today in eNeuro.
In a new study published in the scientific journal of repute Nature Communications researchers from the University of Copenhagen have discovered how an enzyme that plays a key role in cancer development functions. The researchers hope the new knowledge will lead to the design of more precise drugs.
MIT neuroscientists devised a way to measure dopamine in the brain for up to a year, which they believe will teach them much more about its role in key brain functions and in disorders such as depression and Parkinson's disease.
Researchers at University of Utah Health found that ADHD patients had an increased risk of developing Parkinson's and Parkinson-like diseases than individuals with no ADHD history.