As cells age, their ability to shed harmful refuse declines. New research suggests that the deterioration of autophagy in aged neurons could be a risk factor for a suite of neurodegenerative diseases such as ALS (amyotrophic lateral sclerosis), Alzheimer's, and Parkinson's.
Oxidative stress could be a driving force in the spreading of aberrant proteins involved in Parkinson's disease. This is the result of lab studies by researchers of the German Center for Neurodegenerative Diseases (DZNE). The findings are published in the Journal of Clinical Investigation.
Results suggest some forms of PD are an autoimmune disease triggered years before noticeable symptoms.
The naturally occurring molecule N-acetylcysteine (NAC) shows benefit in a clinical trial for Parkinson's Disease.
Scientists have discovered a novel mechanism and role in the brain for hyaluronic acid -- a clear, gooey substance popularized by cosmetic and skin care products. Hyaluronic acid may be the key in how an immune signal moves from the blood stream to the brain, activating the brain's resident immune cells, the microglia. Findings from this study have important implications for better treatments for stroke, neurodegenerative diseases, as well as head injuries.
Researchers at the University of Toronto have uncovered an immune mechanism by which host cells combat bacterial infection, and at the same time found that a protein crucial to that process can sense and respond to misfolded proteins in all mammalian cells.
New research published in the European Journal of Neurology indicates that an active sexual life is linked with lower disability and better quality of life in men with early Parkinson's disease.
Brain-machine interfaces could one day help monitor and treat symptoms of neurological disorders, provide a blueprint to design artificial intelligence, or even enable brain-to-brain communication. But, to achieve the reachable and the quixotic, devices need a way to literally dive deeper into cells to perform reconnaissance. Now, researchers have designed a way to make a nanoscale army that could speed efforts to find out what's happening inside our cells.
Professor Anne Hege Aamodt, President of the Norwegian Neurological Association, presented The Norwegian Brain Health Strategy 2018-2024 to attendees at the congress. Norway are the first country in Europe to launch a national brain health strategy.
An international team of researchers involving members of the University of Basel's Biozentrum challenges the conventional understanding of the cause of Parkinson's disease. The researchers have shown that the inclusions in the brain's neurons, characteristic of Parkinson's disease, are comprised of a membranous medley rather than protein fibrils. The recently published study in 'Nature Neuroscience' raises new questions about the etiology of Parkinson's disease.