The relay station of the brain, the substantia nigra consists of different types of nerve cells and is responsible for controlling the execution of diverse movements. Researchers at the University of Basel's Biozentrum have now characterized two of these cell populations more precisely and has been able to assign an exact function to each of them. The results of the study have now been published in Cell Reports.
Scientists have discovered how mutations in DNA can cause neurodegenerative disease. The discovery is an important step towards better treatment to slow the progression or delay onset in a range of incurable diseases such as Huntington's and motor neurone disease - possibly through the use, in new ways, of existing anti-inflammatory drugs.
Patients who had their appendix removed were more likely to develop Parkinson's disease than those whose appendix remained in place, according to the largest study to address the relationship between the two conditions. The retrospective study involving more than 62 million patient records from 26 health systems will be presented at Digestive Disease Week® (DDW) 2019.
Researchers from Osaka University developed a new device that can measure levels of α-synuclein aggregates in cerebrospinal fluid. This 'HANdai Amyloid Burst Inducer' device amplifies and detects misfolded α-synuclein using ultrasonication. The use of ultrasonication greatly reduced the assay processing time compared with existing methods. Seeding activity of α-synuclein was correlated with disease severity and radiographic examinations.
A team of biophysicists has discovered and studied the structure of the KR2 rhodopsin under physiological conditions. This pioneering work breaks ground for a future breakthrough in optogenetics, a highly relevant area of biomedicine with applications in neurological disease treatment and more. The fundamental discovery will lead to a new instrument for efficient therapy of depression, anxiety disorders, epilepsy, and Parkinson's disease.
A study of a blood pressure drug does not show any benefit for people with Parkinson's disease, according to findings released today that will be presented at the American Academy of Neurology's 71st Annual Meeting in Philadelphia, May 4-10, 2019.
A new Michigan State University study suggests that older adults with poor sense of smell may see an almost 50% increase in their risk of dying within 10 years -- surprisingly in healthier individuals. The research is published in the journal Annals of Internal Medicine.
Researchers led by St. Jude Children's Research Hospital structural biologists have discovered how the cell switches on an executioner mechanism called necroptosis that induces damaged or infected cells to commit suicide to protect the body.
A prescribed drug to treat high blood pressure has shown promise against conditions such as Parkinson's, Huntington's and forms of dementia in studies carried out in mice and zebrafish at the University of Cambridge.
Adjusting the frequency and dosage of Parkinson's patients' medication is complex. In their 'ON' state they respond positively to medication and in their 'OFF' state symptoms return. Addressing these fluctuations requires a clinical exam, history-taking or a patient's self-report, which are not always practical or reliable. A new technology that combines an algorithm with a senor-based system using wearable motion sensors, automatically, continuously and reliably detects a patient's medication ON and OFF states without patient or physician engagement.