An international team of researchers led by Cortexyme co-founders Stephen Dominy, M.D. and Casey Lynch detail the role of a common bacterium, Porphyromonas gingivalis (Pg), in driving Alzheimer's disease pathology and demonstrate the potential for small molecule inhibitors to block the pathogen.
Lead exposure in childhood appears to have long-lasting negative effects on mental health and personality in adulthood, according to a study of people who grew up in the era of leaded gasoline. The findings, which will appear Jan. 23 in JAMA Psychiatry, reveal that the higher a person's blood lead levels at age 11, the more likely they are to show signs of mental illness and difficult personality traits by age 38.
Prions can infect both humans and animals, causing Creutzfeldt-Jakob disease (CJD) in humans, mad cow disease in cattle, and chronic wasting disease in elk and deer. The infectious, misfolded protein particles often go undetected as they destroy brain tissue, causing memory loss, mobility issues, and ultimately death. Preclinical detection of prions has proven difficult, but new research suggests skin samples hold early signs of prion disease that precede neurologic symptoms.
A new, groundbreaking tool for visualizing neural activity has implications for understanding brain functions and disorders, according to new research by University of Alberta scientists and a team of international collaborators.
A natural immune system response may be responsible for inflicting additional harm in the weeks and months after a spinal injury.
Genetic variants damaging neurotransmitter receptor implicated in development of schizophrenia. Genetic variants which prevent a neurotransmitter receptor from working properly have been implicated in the development of schizophrenia, according to research by the UCL Genetics Institute.
Fluorescent tagging of cellular proteins has allowed unprecedentedly detailed images of brain circuits, but imaging neurons and synapses over large areas in fine detail is difficult. Researchers at HHMI, UC Berkeley and MIT have joined two techniques -- expansion microscopy and lattice light-sheet microscopy -- to capture neural circuits, including all synapses, in a whole fly brain in only three days, versus up to 10 years for EM whole-brain imaging. This allows rapid study of brain circuits.
Defects in the transport of cells' energy organelles are a suspected cause of diseases including Alzheimer's, ALS, Huntington's and Parkinson's. A new study reveals the genetics behind mitochondrial shifts.
A special issue of Viral Immunology, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers, contains a rich collection of the latest research and reviews focusing on Viral Neuroimmunology and the intricacies of viral brain infection.
Those who regulate their brain rhythm themselves can release capacities to learn new things.