Editors of the Journal of Clinical Sleep Medicine have identified some of the most significant articles in the publication's history, publishing new commentaries on them in a special 15th anniversary collection. The 15 commentaries from associate editors and members of the journal's editorial board describe the impact of the selected articles both at the time of their publication and today.
An exhaustive dataset drawn from mammalian macrophage cells establishes that macrophage activity is controlled by circadian timing, and - with a substantial mismatch between oscillating proteins and mRNA - hints at unexpected calibration of that timing.
EPFL scientists have carried out the first comprehensive study of how genes in the liver perform their metabolic functions in both space and time of day. Monitoring almost 5000 genes at the level of the individual cell across a 24-hour period, the researchers have modelled how the circadian clock and liver functions crosstalk throughout the day in sync with the feeding-fasting cycle.
Researchers have been trying to figure out what regulates molecular circadian clocks, in search of new insights into diseases like Alzheimer's, cancer and diabetes. Until now, that research has focused on what is known as clock genes. But new research reveals the discovery of a new cog in the circadian clock - a genome-wide regulatory layer made up of small chains of non-coding nucleotides known as micro RNAS (miRNAs).
Women were 39% more likely to die by 1 year after a first stroke. The sex difference was due to advanced age and more severe strokes in women
In previous studies, eye movements and vision were only affected at blood alcohol concentrations (BACs) approaching the legal limit for driving (0.08% BAC), in England, Wales and Northern Ireland.
Spinal cord injury (SCI) often causes disability and seriously compromises quality of life. The major reasons for the difficulty of treatment for SCI might be due to the fact that many neurons are lost during the injury, leading to permanent loss of neural functions. An innovative gene therapy approach regenerated functional new neurons using local glial cells in the injured spinal cord, bringing new hope to millions of SCI patients worldwide.
The American Academy of Sleep Medicine has published a new clinical practice guideline establishing recommendations for the use of behavioral and psychological treatments for chronic insomnia disorder in adults.
Disrupted sleep and other signs of circadian clock problems are common among people with Alzheimer's disease. Researchers at Washington University School of Medicine in St. Louis have discovered a protein that is both regulated by clock genes and involved in clearing away potentially toxic buildup of Alzheimer's proteins in the brain. The protein, YKL-40, could help explain the link between circadian dysfunction and Alzheimer's disease, and provide a new therapeutic target for the neurodegenerative disease.
Young people who prefer to stay up late are more impulsive than their peers who go to bed earlier, which makes them more likely to drink alcohol and smoke, a new study in the journal Chronobiology International, reports.