The current study demonstrates a deleterious effect of midazolam administration prior to myocardial ischemia and reveals reduced circadian protein Period 2 (PER2) levels as the underlying mechanism. These findings highlight PER2 as a cardioprotective mechanism and suggest the PER2 enhancer nobiletin as preventative therapy for myocardial injury in the perioperative setting where midazolam pretreatment occurs frequently.
How many hours people sleep at night may affect their risk of stroke differently based on race, according to a study published in the Oct. 3, 2018, online issue of Neurology®, the medical journal of the American Academy of Neurology.
Light therapy has long been a recognized treatment option for depression. But can it help perimenopausal women struggling with depression and sleep problems as the result of hormone changes? A new study from the University of California suggests that it can by altering a woman's natural sleep/wake cycle. Preliminary study results will be presented during The North American Menopause Society (NAMS) Annual Meeting in San Diego, Oct. 3-6, 2018.
In a new study, researchers at Brigham and Women's Hospital examined a national data sample of risk-taking behaviors and sleep duration self-reported by high school students over eight years and found an association between sleep duration and personal safety risk-taking actions.
Fifty-six percent of parents of teens who have sleep troubles believe the use of electronics is hurting their child's shut-eye.
Using new bioinformatics tools to analyze thousands of human tissue samples, researchers at Cincinnati Children's Hospital Medical Center created a new database of daily rhythms in human gene activity -- including many genes that regulate how drugs work. Reporting in Science Translational Medicine, researchers say their results could have significant implications for a growing field of study called circadian medicine -- timing the administration of drugs or other therapies to coincide with the body's internal clock.
Scientists with the Virginia Tech Carilion Research Institute say a gene involved in the body's circadian rhythms is a potential target for therapies to help patients with a deadly form of brain cancer known as glioblastoma.
The first simple blood test to identify your body's precise internal time clock as compared to the external time has been developed by scientists. The test, which requires only two blood draws, can tell physicians and researchers the time in your body despite the time in the external world. The new test for the first time will provide the opportunity to easily examine the impact of misaligned circadian clocks in a range of diseases from heart disease to diabetes to Alzheimer's.
An international research team led by the University of California, Irvine has identified a system of communication networks that exists among organs and tissues that regulate metabolism. Findings from their study provide, for the first time, a detailed 'atlas' illustrating how the body creates and uses energy, and how imbalances in the networks may impact overall health.
In a paper to be published in the September 2018 issue of Biophysical Reviews and Letters, researchers have discovered that there is a correlation and possible cause and effect between otherwise invisible dark matter particles and melanoma, a type of skin cancer. This opens the door to more research in the interdisciplinary fields of physics and medicine.