SR9009 is a compound that can lead to a wide range of health benefits in animals, including reduced risk of obesity and type 2 diabetes. Until now, researchers have attributed the effects to SR9009's role in altering the body's circadian clock. However, in a first-of-its-kind study from Penn Medicine, researchers found that SR9009 can effect cell growth and metabolic function without the involvement of REV-ERBs.
In a review published May 17, 2019 in the journal Trends in Immunology, researchers discuss how time of day affects the severity of afflictions ranging from allergies to heart attacks.
Circadian clocks of organisms respond to light signals during night but do not respond in daytime. The time window where circadian clocks are insensitive to light signals is referred to as the 'dead zone'. Researchers from Kanazawa University have proposed a mechanism for the daytime dead zone. They report that saturation of a single biochemical reaction in the gene regulatory network that controls circadian oscillations can create a daytime dead zone in different species.
Rutgers researchers have identified a siesta-suppressing gene in fruit flies, which sheds light on the biology that helps many creatures, including humans, balance the benefits of a good nap against those of getting important activities done during the day.
New research from Washington University in St. Louis finds that women and mice both shift their daily schedules earlier by up to a few hours during the first third of their pregnancy. A new study by researchers in Arts & Sciences and at the School of Medicine shows how impending motherhood induces changes in daily timing of a mother which, when disrupted, may put a pregnancy at risk, as reported in the Journal of Biological Rhythms.
Disrupting normal circadian rhythms promotes tumor growth and suppresses the effects of a tumor-fighting drug, according to a new study publishing April 30, 2019 in the open-access journal PLOS Biology by Yool Lee, Amita Sehgal, and colleagues at the University of Pennsylvania.
Research conducted by a team of Washington State University researchers has found that sleep problems in patients with autism spectrum disorder may be linked to a mutation in the gene SHANK3 that in turn regulates the genes of the body's 24-hour day and night cycle. Their study showed that people who were missing the SHANK3 gene and mice that lacked part of the gene had difficulty falling asleep.
Several states in the US, including California, Washington, Florida, and North Carolina, are now considering doing away with the practice by making daylight savings time (DST) permanent. But, researchers reporting in the journal Current Biology on April 22 say, permanent DST would make it harder to wake up in the winter. It would also undermine efforts in many states to give teens more time to sleep in by pushing school start times back.
A new study led by researchers from the University of California, Irvine finds exercising in the morning, rather than at night, may yield better results.
Two papers appearing April 18, 2019 in the journal Cell Metabolism confirm that the circadian clock is an important factor in how the body responds to physical exertion. Based on this work alone, it's too early to say when the best time is for you to go for a jog. But at least in the lab, exercise in the evening seems to be more productive, although human lifestyles are much more complicated.