As cells age, their ability to shed harmful refuse declines. New research suggests that the deterioration of autophagy in aged neurons could be a risk factor for a suite of neurodegenerative diseases such as ALS (amyotrophic lateral sclerosis), Alzheimer's, and Parkinson's.
In the journal Neurobiology of Aging, UC Riverside psychology Chandra Reynolds asserts that those carrying the APOE4 gene score lower on IQ tests during childhood and adolescence. And the effect was stronger in girls than in boys. APOE4 carriers are up to three times more likely to develop late-onset Alzheimer's disease, which occurs in people 65 and older.
The risk factors for stroke and dementia are the same, and a growing body of evidence demonstrates that preventing stroke can also prevent some dementias. Now, a group of experts led by Western University Professor, Dr. Vladimir Hachinski and international collaborators Matthias Endres, Martin Dichgans and Zaven Khachaturian are calling on the global community to come together to take action on preventing dementia by preventing stroke. 'The evidence for doing so is incontestable; the time to act is now,' the authors write.
University at Buffalo researchers have determined that a human gene present in 75% of the population is a key reason why a class of drugs for Alzheimer's disease seemed promising in animal studies only to fail in human studies.
Apathy is the most common neuropsychiatric symptom of dementia, with a bigger impact on function than memory loss -- yet it is under-researched and often forgotten in care.
This multicenter study used in vivo β-amyloid cerebrospinal fluid, a biomarker of Alzheimer's disease, and positron emission tomography findings to track progression of Alzheimer's disease over six years among study participants.
The abnormal accumulation of proteins in the brain is a biological marker for Alzheimer's disease, but the ways in which these proteins spread may help explain why the prevalence of Alzheimer's is higher in women than in men.
In a new study published in the Journal of Gerontological Nursing, Prusaczyk and colleagues showed that older patients with dementia at one major teaching hospital were less often provided with transitional care steps including patient education, discharge planning, and documentation of medication history, as compared to patients without dementia.
Higher levels of daily physical activity may protect against the cognitive decline and neurodegeneration (brain tissue loss) from Alzheimer's disease.
A study led by researchers of the Spanish National Research Council (CSIC) and published in the journal Nature Neuroscience has identified a new therapeutic target for the treatment of Alzheimer's disease. The results of the work reveal that, in human samples from Alzheimer's patients, the levels of the protein SFRP1 are abnormally elevated and continue to increase with the progress of the disease.