There is a considerable overlap between vascular and Alzheimer's disease (AD) risk factors. In addition, incident stroke approximately doubles the risk of developing AD. Oxidative stress is significantly involved in the pathogenesis of AD and suffers a dramatic increase in the setting of acute ischemic stroke, especially in cardioembolic stroke, followed by lacunar stroke, as shown in a previous study. Dampening this oxidative burst could delay the onset of subsequent dementia in stroke survivors.
In sufferers of Parkinson's disease, clumps of α-synuclein (alpha-synuclein), sometimes known as the 'Parkinson's protein', are found in the brain. These destroy cell membranes, eventually resulting in cell death. Now, a new method developed at Chalmers University of Technology, Sweden, reveals how the composition of cell membranes seems to be a decisive factor for how small quantities of α-synuclein cause damage.
Scientists have used advanced technology to 'micro-dissect' the first brain cells to perish in Alzheimer's disease. The result is a short list of genes that could represent new drug targets.
A new study reveals that the common asthma drug salbutamol may offer potential as a treatment for Alzheimer's disease.
A team led by Case Western Reserve University medical researchers has developed a potential treatment method for Pelizaeus-Merzbacher disease (PMD), a fatal neurological disorder that produces severe movement, motor and cognitive dysfunction in children. It results from genetic mutations that prevent the body from properly making myelin, the protective insulation around nerve cells.
There's good news for people with Parkinson's disease. A new study shows that deep brain stimulation may not increase the risk of developing dementia. The study is published in the July 1, 2020, online issue of Neurology®, the medical journal of the American Academy of Neurology.
NMDA receptors convert chemical messages into electrical signals within a neuron. The key to transmitting information is opening the receptor's built-in ion channel, a hollow pore that allows electrically-charged ions to flow. Hiro Furokawa's lab discovered that unlocking the receptor's ion channel is like working a stringed puppet - rock one part of the receptor and filaments pull open the channel's gate. Rock it a little differently, the filaments loosen, and the gate snaps shut.
Researchers using MRI have found that iron accumulation in the outer layer of the brain is associated with cognitive deterioration in people with Alzheimer's disease, according to a new study.
Researchers used a smartphone app to 'eavesdrop' on older adult conversations. They found that the older a person is, the less likely they are to share memories of past experiences.
Some neuron types are particularly prone to Alzheimer's, and a new study suggests that those neurons are vulnerable because they regularly remodel. The work is the first to track the progression of Alzheimer's at the genetic and molecular levels within the neurons most susceptible to the disease. The findings suggest that aging and the accumulation amyloid-beta can cause the remodeling process to go awry, creating tangles of tau proteins that lead to neuron death.