People may be deteriorating into dementia later in life and living with it for a shorter period of time, a new study suggests.
Parvalbumin, a protein found in great quantities in several different fish species, has been shown to help prevent the formation of certain protein structures closely associated with Parkinson's disease. A new study from Chalmers University of Technology, Sweden, shines more light on the link between consumption of fish and better long-term neurological health.
The rate at which the protein beta-amyloid accumulates into the sticky plaques associated with Alzheimer's disease (AD) is already slowing by the time a patient would be considered to have preclinical AD, according to a longitudinal study of healthy adults published in JNeurosci. The research suggests that anti-amyloid therapies would be most effective before individuals reach the threshold for preclinical AD, long before the first signs of memory issues.
In a large population-based study of randomly selected participants in Germany, researchers found that participants aged 65-74 years with olfactory dysfunction showed impaired cognitive performance. Interestingly, this strong association was not present in younger (55-64 years) or older (75-86 years) participants. Additionally, the effect was more present in women than men.
A host of nuclear RNA-binding proteins, when misplaced outside the nucleus, form the harmful clumps seen in several brain disorders, including FTD and ALS. Clumps that form from these disease proteins are composed of sticky fibrils that damage nerve cells. Researchers are trying to reverse the formation of these and put the RNA-binding proteins back in their proper place, inside the nucleus.
A study headed by researchers at the Institute for Research in Biomedicine (IRB Barcelona) and the Institut Européen de Chimie et Biologie (IECB) in France proposes that the presence of two beta-amyloid molecules bound together (beta-amyloid dimers) could provide a new biomarker for AD.
A new supplement to the Journal of the American Geriatrics Society finds field leaders in dementia and mental health research weighing in on the science, public policy, and professional education and practice that will change our experience of aging.
Using two complementary approaches to reduce the deposits of amyloid-beta in the brain rather than either approach alone improved spatial navigation and memory in a mouse model of Alzheimer's disease.
A newly published observational study from the Regenstrief Institute and Indiana University has found that increased levels of education, particularly for those who grew up in low-income rural areas, was significantly associated with the decrease in the risk of dementia and Alzheimer's disease in older African-Americans previously reported by the same research group.
The prevention of chronic diseases associated with increased risk of dementia will not reduce the number of Americans with dementia in the coming decades, but developing a treatment that delays onset will significantly reduce the burden of dementia.