One major problem with understanding Alzheimer's is not being able to clearly see why the disease starts. A super-resolution 'nanoscope' developed by Purdue University researchers now provides a 3D view of brain molecules with 10 times greater detail. This imaging technique could help reveal how the disease progresses and where new treatments could intervene.
Actigraphy can be a useful clinical tool for the evaluation of adult and pediatric patients with suspected sleep disorders, including circadian rhythm sleep-wake disorders, according to a clinical practice guideline from the American Academy of Sleep Medicine (AASM).
According to a new National Institutes of Health-funded study, it is not destiny that brings two fruit flies together, but an evolutionary matchmaker of sorts that made tiny adjustments to their brains' mating circuits, so they would be attracted to one another while rejecting advances from other, even closely-related, species. The results, published in Nature, may help explain how a specific female scent triggers completely different responses in different male flies.
Numerous studies to date have shown that olfactory receptors are relevant not only for smell perception, but that they also play a significant physiological and pathophysiological role in all organs. An overview of receptors detected so far and of the functions they fulfil within the human body is provided by researchers from Ruhr-Universität Bochum, published in the journal Physiological Reviews;.
A fatal neurodegenerative condition known as Gaucher disease can be prevented in mice following fetal gene therapy, finds a new study led by UCL, the KK Women's and Children's Hospital and National University Health System in Singapore. The study, published today in Nature Medicine, highlights the potential of fetal gene therapy to prevent and cure neonatal lethal neurodegenerative diseases in humans in utero.
Researchers at the Max Planck Florida Institute for Neuroscience demonstrate that PKC is a highly versatile molecule, capable of assimilating many disparate sources of information. Because of this adaptability, the protein is well poised as a mediator of the processes underlying synaptic plasticity and learning. This work represents a substantial advancement in the field, providing integral tools that will enable the disentanglement of complex signaling related to learning and memory.
New research led by Washington University School of Medicine in St. Louis indicates an investigational therapy for an inherited form of ALS extends survival and reverses signs of neuromuscular damage in mice and rats. The findings, published July 16 in The Journal of Clinical Investigation, have led to a phase one/two clinical trial to investigate whether the drug could benefit people with ALS whose disease is caused by mutations in a gene called SOD1.
A new study in The American Journal of Pathology found that a brain lipid molecule, lysophosphatidic acid (LPA), was significantly increased after traumatic brain injury (TBI) in a preclinical animal model. They also found that it was elevated in areas associated with cell death and axonal injury, both major hallmarks of moderate and severe TBI. This strengthens the evidence that LPA could be used as a biomarker of TBI through blood testing, potentially providing a prognostic indicator of injury and outcome.
Yale researchers have tested a new method for directly measuring synaptic loss in individuals with Alzheimer's disease. The method, which uses PET imaging technology to scan for a specific protein in the brain linked to synapses, has the potential to accelerate research for new Alzheimer's treatments, the researchers said.
Canadian researchers document the health problems that precede a diagnosis of multiple sclerosis.