Obesity can break down our protective blood brain barrier resulting in problems with learning and memory, scientists report.
Study finds drug could have new applications in non-diabetics.
Researchers have discovered a key clue into the development of the pancreas and brain by studying rare patients born without a pancreas. The study, published in the American Journal of Human Genetics, from the Wellcome Sanger Institute and University of Exeter also identified an unexpected pathway in human pancreas development, and confirmed this in mice. Understanding how the pancreas forms could help develop replacement cells to treat patients with type 1 diabetes in the future.
A new study shows that a synthetic molecule developed by Oregon Health & Science University scientists stimulates repair of the protective sheath that covers nerve cells in the brain and spinal cord. The study demonstrates in mice that a synthetic molecule called sobetirome efficiently repairs damaged myelin without side effects.
Whether a wound -- such as a diabetic foot ulcer -- heals or progresses to a worse outcome, including infection or even amputation, may depend on the microbiome within that wound.
Around four million people in the UK carry genetic variants that protect them from obesity, type 2 diabetes and heart disease, suggests new research from the University of Cambridge. The team say the discovery could lead to the development of new drugs that help people lose weight.
Two papers appearing April 18, 2019 in the journal Cell Metabolism confirm that the circadian clock is an important factor in how the body responds to physical exertion. Based on this work alone, it's too early to say when the best time is for you to go for a jog. But at least in the lab, exercise in the evening seems to be more productive, although human lifestyles are much more complicated.
There has been a fierce debate over the last decade or so about the health benefits of omega-6 fatty acids. One side believes they are too ubiquitous in the diet and fuel the inflammation underpinning many of today's chronic diseases. Another side believes that the most consumed omega-6 -- linoleic acid (LA) -- could be just as important as omega-3s in reducing disease risk.
Researchers have developed a high-tech support system that can keep a large mammalian brain from rapidly decomposing in the hours after death, enabling study of certain molecular and cellular functions. With funding through the NIH BRAIN Initiative, researchers developed a way to deliver an artificial blood supply to the isolated postmortem brain of a pig, preventing the degradation that would otherwise destroy many cellular and molecular functions and render it unsuitable for study.
Metformin could reverse the harmful thickening of heart muscle that leads to cardiovascular disease, according to researchers at the University of Dundee. The findings of the study if implemented could potentially save the NHS billions of pounds every year and offer hope for millions of patients across the globe.