Researchers have discovered a mechanism of action underlying a widely used diabetes drug, which may expand its indications for use, as well as open new inroads in pharmaceutical development.
Diabetes is characterized by persistent high blood sugar levels that occur when certain cells in the pancreas -- the insulin-producing cells -- are destroyed or are no longer able to secrete insulin. Researchers at the University of Geneva, Switzerland, have succeeded in showing how part of the pancreatic cells, which usually produce other hormones, can take over from the damaged cells by starting to produce insulin. These results lead to envision entirely new therapeutic strategies.
With the help of a free phone app, low-income obese patients with signs of cardiovascular risk lost a clinically meaningful amount of weight, finds new research from Duke University. The study is among the first to report successful weight loss within a low-income population -- a group that suffers from skyrocketing rates of obesity but has proven hard to treat, said lead author Gary Bennett.
This study identified a shift in the kind of metabolic and bariatric surgery (so-called MBS surgery because it can help patients achieve long-term weight loss and the resolution of coexisting metabolic conditions such as type 2 diabetes) performed among pediatric patients.
Most parents know that the diet and exercise habits of a pregnant woman impacts the health of her baby, but little is known about how a father's health choices are passed to his children. A new study by researchers at The Ohio State University Wexner Medical Center finds that lifestyle practices of fathers prior to conception may have a major impact on the lifelong health of their children.
Research shows metformin, a commonly prescribed drug for type 2 diabetes prevents heart disease in patients with type 1 diabetes.
Adding refined soluble fiber to processed foods could present a health risk for certain people, researchers say in newly published study.
A Loyola University Chicago Stritch School of Medicine study reveals how, on a cellular level, diabetes can cause heart failure. The findings could lead to medications to treat and perhaps prevent heart failure in diabetes patients.
A drug first identified 150 years ago and used as a smooth-muscle relaxant might make tumors more sensitive to radiation therapy. Researchers found that the drug papaverine inhibits the respiration of mitochondria, the oxygen-consuming and energy-making components of cells, and sensitizes model tumors to radiation. They found that the drug does not affect the radiation sensitivity of well-oxygenated normal tissues.
Scientists who performed the largest-ever genetic study of a puzzling type of adult-onset diabetes have uncovered new connections to the two major types of diabetes, offering intriguing insights into more accurate diagnosis and better treatment. Latent automimmune diabetes in adults (LADA) is a relatively common disorder that shares features of type 1 diabetes and type 2 diabetes.