Scientists of the German Center for Diabetes Research (DZD) in Tübingen discovered that a fatty liver can cause damage to other organs. In two just-published studies they demonstrate the effects of fatty liver disease on the function of the hormone-producing islet cells in the pancreas and on renal function.
A new Michigan State University study on 240 emergency room patients shows just how much of a role a person's cholesterol plays, when in a crystallized state, during a heart attack.
NPGL, a recently discovered protein involved in brain signalling, has been found to increase fat storage by the body -- even when on a low-calorie diet. In addition, NPGL was shown to increase appetite in response to high caloric food intake, suggesting that perhaps we shouldn't feel so guilty about gorging on junk food from time to time.
Adolescence can be turbulent period of life, with struggles to establish autonomy, identity issues and risk-taking behaviours. For young adults with a chronic illness such as type 1 diabetes, this transition phase also means they must assume an increased responsibility for their overall health. A study from the McGill University Health Centre sheds light on gaps in transition care practice in Quebec, pointing out a lack of standardized policies across pediatric diabetes centers.
Patients at risk for type 2 diabetes are often asked to exercise, but exercise doesn't help each patient equally. To investigate this variability, a sample of women were divided by their levels of insulin resistance (lower/ higher), a warning sign for diabetes, all underwent high-intensity interval training. The training generally improved all metrics of cardiometabolic health tested. Women with higher insulin resistance more often saw improvements in the measures of glucose and insulin in their blood.
New research has revealed that some of the toxin formaldehyde in our bodies does not come from our environment -- it is a by-product of an essential reaction inside our own cells. This could provide new targets for developing cancer therapies, according to research led by scientists from the Medical Research Council Laboratory of Molecular Biology.
Hemodialysis requires repeated access to the blood. Failure to maintain adequate access to the vasculature is a major cause of medical complications and, potentially, death for these patients. A new study in The American Journal of Pathology provides information about the mechanisms underlying failure of the most common type of hemodialysis vascular access, the arteriovenous fistula. Despite being the preferred approach, there is currently limited understanding of the mechanisms involved in fistula maturation failure.
Researchers show that an intracellular metabolite of glutamine, alpha-ketoglutarate, plays a role in regulating cellular differentiation programs by changing the DNA-binding patterns of the transcription factor CTCF and by altering genome interactions. As an added level of gene program control complexity, they have found that the genome's context near the binding sites -- such as epigenetic changes or altered genome topology -- affects whether the binding turns on or turns off gene programs.
A high amount and intensity of exercise along with a diet plan resulted in a modest reduction in blood glucose levels among adults with type 2 diabetes, but was accompanied by reductions in the use of glucose-lowering medications, according to a study published by JAMA.
A group of U of T Engineering researchers has demonstrated that the space under our skin might be an optimal location to treat type 1 diabetes (T1D).