A chemical used in hydraulic fracturing, commonly called fracking, has the potential to interfere with reproductive hormones in men, according to research accepted for presentation at ENDO 2020, the Endocrine Society's annual meeting, and publication in a special supplemental section of the Journal of the Endocrine Society.
The present study revealed impairment of lipid metabolism in papillae with calcified plaque tissue and down-regulation of fatty acid-binding protein 4 (FABP4) associated with plaque formation. Immunohistochemistry of human kidney specimens and experiments of nephrocalcinosis model mice and Fabp4 knockout mice validated FABP4 down-regulation as an important feature of papillary plaques and stone formation in the kidney. FABP4 appears to be a key molecule and therapeutic target for kidney stone.
Researchers at the University of East Anglia have discovered why some prostate cancers are more aggressive, spread to different parts of the body, and ultimately cause death. It is hoped that the discovery, published today, could transform patient treatment.
Botulinum toxins are FDA-approved and widely used. Although they are safe and effective, they can drift away from the site of injection, reducing efficacy and causing side effects. New work from Boston Children's Hospital on botulinum B combined structural modeling and genetic engineering to enable the toxin to bind more tightly to nerve cells and stay in place. This led to more effective, longer-lasting local muscle paralysis and reduced toxicity.
In a new retrospective study, researchers found that the use of immunosuppressive therapy does not increase the occurrence or recurrence of vulvar or vaginal cancer in women with inflammatory bowel disease (IBD). However, earlier onset of cancer was reported, and lymphomas were found in some patients, which is very rare in the genital tract. Their results appear in Digestive and Liver Disease, published by Elsevier.
A researcher at James Cook University in Australia says scientists have found that exercise can be beneficial to patients as they begin treatment for prostate cancer.
Patients who used copper intrauterine devices were found to have a lower risk of cervical cancer compared to users of the levonorgestrel-releasing intrauterine system.
Keck Medicine of USC urologists are launching a clinical trial to evaluate the effectiveness of spinal cord stimulation in patients with an overactive bladder due to neurological conditions, such as a spinal cord injury or stroke, and idiopathic (unknown) causes.
Unnecessary prostate cancer biopsies could be reduced by 60% thanks to new research from the University of East Anglia. Researchers have developed new methods to identify biomarkers for prostate cancer by combining information from multiple parts of urine samples. It is hoped that the breakthrough could help large numbers of men avoid an unnecessary initial biopsy.
An antidepressant from the '50s, repurposed to fight prostate cancer, lowered PSA levels in men with recurrent disease, pilot study shows.