Two new mouse models of uterine cancer reveal that the TGF-beta signaling pathway in uterine cells protects against the disease by suppressing the overgrowth and oncogenesis of the endometrium, the membrane lining the inside of the uterus.
Waves of undulating cilia drive several processes essential to life. They clear debris and mucus from the respiratory tract, move spinal fluid through the brain and transport embryos from the ovaries to the uterus for implantation. According to a new study in mice, however, cilia perform somewhat differently in the male reproductive tract.
The study has potential implications for families with members suffering from these types of tumours who are at an increased risk of developing cancer. The finding is based on PROREPAIR-B, a prospective multi-centre observational cohort study that followed up more than 400 patients with metastatic prostate cancer, aimed to identify genetic markers associated with its progression and treatment response. Further studies will evaluate whether patients with BRCA2 mutations can undergo treatments used in patients with ovarian and breast cancer.
A new questionnaire being developed through a collaboration between the Massachusetts General Hospital Midlife Women's Health Center and the North American Menopause Society is designed to improve knowledge of the extent and impact on women of genitourinary symptoms of menopause.
Neuroscientists and engineers at Washington University School of Medicine in St. Louis, the University of Illinois at Urbana-Champaign, and the Feinberg School of Medicine at Northwestern University in Chicago, have developed a tiny, implantable device that has potential to help people with bladder problems bypass the need for medication or electronic stimulators. The team created a soft, implantable device that can detect overactivity in the bladder and then use light from tiny, biointegrated LEDs to tamp down the urge to urinate.
The fruit of genus Rosa, known as 'rose hip,' is frequently used in different traditional medicines. Rose hips have long been used to treat kidney stones, gastroenteric ailments, hypertension and respiratory problems such as bronchitis, cough and cold. This review is focused on the ethnopharmacological uses of rose hip as well as phytochemical and pharmacological aspects.
This systematic review and meta-analysis of randomized controlled trials (RCTs) were conducted to determine the effects of coenzyme Q10 (CoQ10) supplementation on metabolic profiles of patients diagnosed with chronic kidney disease (CKD).
DNA sequencing can be used to identify the underlying genetic cause of many rare types of chronic kidney disease, leading to better treatment, finds a new study from Columbia University.
A new study suggests that antibiotics are being overused in up to 50 percent of patients undergoing common urological procedures. The study, led by Daniel Livorsi, M.D., University of Iowa assistant professor of internal medicine, shows that the high rates of overuse were mostly due to extended use of antibiotics following the procedure. The findings were published Dec. 21 in JAMA Network Open.
How does a normal cell turn into a deadly cancer? Seeking an answer to this Question researchers from Charité -- Universitätsmedizin Berlin examined the tumor genomes of nearly 300 prostate cancer patients. Their findings describe the ways in which changes in the prostate cells' genetic information pave the way for cancer development. Using a newly developed computer model, it is now possible to predict the course of the disease in individual patients. The results of this study were now published in Cancer Cell.