Most nonpharmacologic and pharmacologic interventions are more likely than no treatment to improve outcomes for women with either stress or urgency urinary incontinence (UI). Behavioral therapy, alone or in combination with other interventions, was found to be generally more effective than pharmacologic therapies alone. Findings from a systematic evidence review and network meta-analysis of clinical outcomes of nonpharmacologic and pharmacologic interventions for UI are published in Annals of Internal Medicine.
Prior to the development of antiviral therapy, kidney transplant recipients infected with either hepatitis B (HBV) or hepatitis C (HCV) experienced poor outcomes. In a new study in the Journal of Hepatology, published by Elsevier, researchers report favorable 10-year survival rates for patients with HBV and/or HCV treated with antiviral agents and advise that antiviral therapy should be systematically offered to all HBV and HCV patients in line with international recommendations.
A new drug takes out the 'seeds' that cause ovarian cancer to come back after chemotherapy.
A new study from non-profit research organisation RAND Europe examines how waking up at night due to nocturia, a urinary tract condition, can have a detrimental effect on a person's wellbeing and productivity at work, which in turn has an impact on a country's GDP. The study's finding show that frequent visits to the bathroom at night could cost the US economy $44.4 billion a year.
To enable the study of renal reabsorption outside the human body, a team at the Wyss Institute created a 3D vascularized proximal tubule and used it to measure the transport of glucose from the proximal tubule to the blood vessels, along with the effects of hyperglycemia, a condition associated with diabetes in patients.
By loading a chelation drug into a nano-sized homing device, researchers at Clemson University have reversed in an animal model the deadliest effects of chronic kidney disease, which kills more people in the United States each year than breast or prostate cancer.
Men with early stage testicular cancer can safely receive one course of chemotherapy or radiotherapy after surgery without it having a long-term effect on their sperm count, according to a study published in Annals of Oncology. Until now, this has not been clear, although it is known already that several rounds of chemotherapy or high doses of radiotherapy given to men with more advanced testicular cancer can reduce sperm count and concentration.
Over-testing for urinary tract infections (UTIs) leads to unnecessary antibiotic use, which spreads antibiotic resistance. Infectious disease specialists at Washington University School of Medicine in St. Louis made changes to hospital procedures that cut urine tests by nearly half without compromising doctors' abilities to detect UTIs.
Cholesterol-lowering statin drugs reduce the risk of cardiovascular disease in kidney disease patients who are not on dialysis. But a new study finds that statins are used by only 21.8 percent of such patients who do not already have cardiovascular disease or diabetes or have not been diagnosed with high cholesterol.
Label-free digital pathology using infrared (IR) imaging with subsequent proteomic analysis for bladder cancer (BC) has revealed the first protein biomarker (AHNAK2) for BC. AHNAK2 differentiates between chronic cystitis (inflammation of the bladder) and a non-muscle invasive-type BC (carcinoma in situ) which is challenging to diagnose. A report in The American Journal of Pathology describes this new diagnostic procedure, which is label-free, automated, observer-independent, and as sensitive and specific as established histopathological methods.