Alport syndrome (AS) is a hereditary kidney disease caused by protein (collagen) abnormalities. Unfortunately, treatment through the correction of collagen functionality has not yet been developed. Now, Japanese researchers have established a method to assess collagen complex integrity in AS, making it possible to develop therapeutic drugs. This detection system reduces labor and time costs compared to conventional methods, and can monitor type IV collagen functionality with high sensitivity.
Researchers at Washington University School of Medicine in St. Louis have designed sugar molecules that block E. coli bacteria from binding to urinary tissues, allowing the bacteria to be washed out of the urinary tract. The compounds represent a step toward treating UTIs without antibiotics.
Aseem R. Shukla, M.D., a pediatric urologist at Children's Hospital of Philadelphia, along with several of his colleagues from around the world, have created an innovative program to help address urological needs in India. The team is specifically addressing bladder exstrophy, a complex, rare disorder that occurs during fetal development when the bladder does not form completely and drains onto the surface of the abdomen.
An Italian study featured in the March issue of The Journal of Nuclear Medicine demonstrates that a novel nuclear medicine imaging agent targeting copper accumulation in tumors can detect prostate cancer recurrence early in patients with biochemical relapse (rising prostate-specific antigen [PSA] level).
Marijuana is the most commonly used illicit drug in the United States, with an increasing trend of use among middle-aged and older individuals. However, potential health effects of marijuana use in the general population have not been extensively studied, and little is known about potential effects on kidney function. According to a new cross-sectional study of adults aged 18-59 in the US, there is no association between current or previous marijuana use and kidney function.
A heart attack triggers an acute inflammatory response at the damaged portion of the heart's left ventricle. If the inflammation lingers, it can lead heart failure. The inflammation can also claim another victim -- the kidneys. New research shows that a bioactive compound called resolvin D-1, injected as a therapeutic dose, is able to limit this collateral damage in the kidneys, as tested in an animal model. This suggests potential application to the clinical setting.
New research in mice has found that a father's stress affects the brain development of his offspring. This stress changes the father's sperm, which can then alter the brain development of the child. This new research provides a much better understanding of the key role that fathers play in the brain development of offspring.
Ebola virus can infect reproductive organs of male and female macaques, according to a new study, suggesting humans could be similarly infected. Prior studies have revealed sexual transmission of Ebola virus, and viral RNA persisting in semen following recovery. While little is known about viral persistence in female reproductive tissues, pregnant women with Ebola virus disease have a maternal death rate of more than 80 percent and a fetal death rate of nearly 100 percent.
A multi-institutional phase 3 trial led by investigators at Massachusetts General Hospital and University of California, San Francisco found that treatment with an investigational androgen receptor inhibitor significantly delayed the development of metastasis in patients with prostate cancer that had become resistant to standard androgen-deprivation therapy.
A new study suggests that chronic inflammation caused by obesity may harm the male genital tract, leading to lower fertility in obese men.