A description of how ovarian cancer cells adapt to survive and proliferate in the peritoneal cavity has been detailed by a new study. It shows structures inside the cells change as the disease progresses, to help the cells grow in an otherwise hostile environment of low oxygen and nutrients. Understanding how these cellular adaptations are regulated could herald new targeted treatment options against the fifth-leading cause of cancer-related deaths in women.
A change in evidence-based guidelines for vasectomy may have led to a reduction in the number of follow-up tests to confirm the procedure was successful, reports a study in Urology Practice®, an Official Journal of the American Urological Association (AUA). The journal is published in the Lippincott portfolio by Wolters Kluwer.
As anyone living with hay fever can attest, days with high pollen counts can bring attacks of sneezing, nasal congestion and other allergy symptoms. Now, a new study suggests rising pollen levels may also trigger flare-ups of pain and other symptoms in patients with urologic chronic pelvic pain syndrome (UCPPS), reports The Journal of Urology®, Official Journal of the American Urological Association (AUA). The journal is published in the Lippincott portfolio by Wolters Kluwer.
The bacteria Streptococcus pneumoniae colonizes the nasopharynx and can cause pneumonia. Then, it can spread to the bloodstream and cause organ damage. To understand how this pathogen adapts to different locations in the body, and also how the host responds to the microbe, researchers have measured bacterial and host gene expression at five different sites in a mouse model -- the nasopharynx, lungs, blood, heart and kidneys -- using three genetically different strains of S. pneumoniae.
Plastics contain and leach hazardous chemicals, including endocrine-disrupting chemicals (EDCs) that threaten human health. An authoritative new report, Plastics, EDCs, & Health, from the Endocrine Society and the IPEN (International Pollutants Elimination Network), presents a summary of international research on the health impacts of EDCs and describes the alarming health effects of widespread contamination from EDCs in plastics.
Researchers at the University of Colorado Anschutz Medical Campus have discovered that fructose stimulates the release of vasopressin, a hormone linked to obesity and diabetes. They also found that water can suppress the hormone and alleviate these conditions in mice.
New research shows that the antiviral activity of the drug -- called phenylbutyrate, or PBA -- was even better when used along with acyclovir, a common HSV-1 treatment. When used in combination, less acyclovir is needed to effectively suppress the virus compared to acyclovir alone -- this is important because acyclovir is also known to have toxic side effects in the kidneys.
The combination of mild electrical stimulation and heat shock at 42 °C (MES+HS) exerts anti-inflammatory and anti-fibrotic effects in a mouse model of nephrotic syndrome (NS) by inhibiting apoptosis (cell death) of kidney cells. Clinical data have shown that the medical device used for this therapeutic approach is safe in humans. Researchers believe that it can be applied clinically to control the pathologies of NS.
A team from the Institut national de la recherche scientifique (INRS) has demonstrated the effectiveness of an inexpensive molecule to fight antibiotic-resistant strains of the bacteria responsible for gonorrhea and meningococcal meningitis. These two infections affect millions of people worldwide. The results of this research, led by Professor Frédéric Veyrier and Professor Annie Castonguay, have just been published online in the Antimicrobial Agents and Chemotherapy journal.
Researchers from Kaunas University of Technology (KTU), Lithuania came up with the idea on how to measure fluctuating blood potassium levels non-invasively, through electrocardiogram. The researchers claim that their method may become a digital biomarker in the future for managing electrolyte levels. This would be a huge step towards preventing potentially life-threatening conditions among people who suffer from chronic kidney disease.