Lipid, also known as fat, is an optimal energy source and an important cell component. Much is required for the rapid and uncontrolled growth of cancer cells. Researchers from the Biozentrum of the University of Basel and from the University of Geneva have now discovered that the protein mTOR stimulates the production of lipids in liver tumors to satisfy the increased nutrient turnover and energy needs of cancer cells among other functions.
The unique liver function of a South American amphibian, Siphonops annulatus, could pave the way to finding a cure to the devastating liver condition cirrhosis, a new study published in the prestigious Journal of Anatomy reports.
Researchers report creating a biologically accurate mass-production platform that overcomes major barriers to bioengineering human liver tissues suitable for therapeutic transplant into people. A team led by the Cincinnati Children's Center for Stem Cell and Organoid Medicine (CuSTOM) and Yokohama City University in Japan report their findings Dec. 5 in Cell Reports. The study overcomes what have been nagging challenges for researchers working to bioengineer human organs that are safe and effective for therapeutic use.
A novel technology developed by researchers at the Massachusetts General Hospital enables the model-ing of human liver transplantation in an experimental setting.
A new study provides insights into the interaction between alcohol consumption and metabolic factors in predicting severe liver disease in the general population.
Biliary atresia is the most common cause of liver transplants for children in the United States. Researchers report in Science Translational Medicine finding a strong biomarker candidate that could be used for earlier diagnosis and lifesaving treatments that could avoid more invasive procedures like liver transplant. A research team led by Cincinnati Children's Hospital Medical Center identified molecular markers of the disease in blood samples that accurately diagnosed the condition with greater than 90 percent sensitivity.
Scientists have engineered a mouse model to study a rare and often-fatal form of liver cancer. They've used it to clarify what drives these tumors at the molecular level, and discover new drug concepts.
Serious liver and heart problems can affect children with Alagille Syndrome early in life. While there is as yet no cure, researchers at Karolinska Institutet in Sweden have discovered that the liver disease part of the syndrome is caused by specific malformations of the bile ducts. The results, which are published in the journal Gastroenterology, were discovered with the aid of a new mouse model that can now be used to develop and test new therapies.
The American College of Physicians and the Centers for Disease Control and Prevention say that hepatitis B is a serious health threat and should be a public health priority. They recommend screening at-risk adults, increasing hepatitis B vaccination rates, and linking infected persons to care.
Reducing chronic hepatitis B infections by screening at-risk adults, increasing hepatitis B vaccination rates, and linking infected persons to care is a public health priority, the American College of Physicians and the Centers for Disease Control and Prevention advise in a new paper published today in Annals of Internal Medicine.