New research from UPMC and Pitt shows that living-donor liver transplant offers numerous advantages over deceased-donor transplant, including superior outcomes and less resource utilization.
Researchers from Clemson University's Environmental Toxicology Program have published research connecting an enzyme associated with detoxification to obesity and fatty liver disease, especially in males.
Scientists at the 2019 ASCO Annual Meeting presented research that relied on Droplet Digital PCR to explore the strengths and limitations of using circulating tumor DNA as a biomarker for predicting outcomes and guiding treatment for patients with cancer.
New findings show how a genetically aberrant, fused protein molecule, created by a liver cell mutation, promotes a rare, difficult to treat, cancer in young people. By screening several drug combinations, researchers found a set that targeted both the fused protein and the enzymes that it recruits. In the lab, this mix of drugs slowed down uncontrolled growth of mouse cells engineered to carry the cancer-causing mutation.
An innovation in liver function testing could detect liver disease decades before it becomes fatal.
Chronic diseases, such as stroke, ischemic heart disease, and lung cancer, now represent the leading causes of premature death in China, according to a new scientific study. The rise in non-communicable diseases reflects declines in maternal and child mortality over nearly three decades, largely the result of economic growth and increasing levels of education. In addition, China has instituted national programs targeting infectious diseases.
In 2017, the majority (58%) of the almost 27 000 newly reported hepatitis B cases in the European Union and European Economic Area were classified as chronic infections. This follows a consistent upward trend in reported chronic hepatitis B cases since 2008.
In a recent study published in the journal Developmental Cell, NYU Abu Dhabi researchers have reported a new way in which the liver is primed to regenerate itself. They found that by stripping parts of the epigenome, which play a primary role in repressing 'jumping genes' (i.e. transposable elements), other epigenetic marks were redistributed.
Christopher McAleer and colleagues have created a new multiorgan-on-a-chip system that can accurately capture the toxic effects of chemotherapies that have been metabolized by the liver -- effects usually not seen in standard cell culture preclinical drug development.
Scientists at Cincinnati Children's Hospital Medical Center have identified an expression pattern of 14 genes at the time of diagnosis that predicts two year, transplant-free survival in children with biliary atresia -- the most common diagnosis leading to liver transplants in children.