A newly developed drug can prevent the most common type of pancreatic cancer from growing and spreading in laboratory mice, according to a study led by Cedars-Sinai. The study also demonstrated in mice that the drug, Metavert, may prevent patients from developing a resistance to currently used pancreatic cancer chemotherapies.
Researchers at Mount Sinai have discovered that an antimicrobial protein found in the gut can stave off a common and highly lethal side effect of bone marrow transplants, according to a study published in the Journal of Clinical Investigation in September.
Diabetes is not the only disease on which insulin has an effect, it appears. In a new study that involved tests on mice researchers from the University of Copenhagen, among others, have discovered a new method for treating chronic colitis with regular insulin. The researchers have set up a company with a view to testing the treatment and hopefully making it available to patients.
With an estimated 1.6 million people in the US dealing with inflammatory bowel disease (IBD), physicians can have a hard time telling which newly diagnosed patients have a high risk of severe inflammation or what therapies will be most effective. Now researchers report in the journal JCI Insights finding an epigenetic signature in patient cells that appears to predict inflammation risk in a serious type of IBD called Crohn's disease.
Searching for a more direct connection between the gut and the brain, Duke researchers were shocked to see that distance spanned by a single synapse, relaying the signal in less than 100 milliseconds, less than the blink of an eye. The finding in the journal Science has profound implications for the understanding of appetite and appetite suppressants, most of which target slow-acting hormones rather than fast-acting synapses.
Scientists working to bioengineer the entire human gastrointestinal system in a laboratory now report using pluripotent stem cells to grow human esophageal organoids. The newly published research in the journal Cell Stem Cell is the first time scientists have been able to grow human esophageal tissue entirely from pluripotent stem cells (PSCs), which can form any tissue type in the body.
New high-resolution maps pinpoint areas across Africa with concentrations of child deaths from diarrhea and show uneven progress over 15 years to mitigate the problem. The study, covering 2000 to 2015, maps the entire African continent in 5x5 square kilometer units and was published today in The New England Journal of Medicine. National and provincial maps of diarrhea in Africa often mask inequalities at the local community level, according to IHME researchers.
New University of Otago research shows infants using popular anti-reflux medicines like omeprazole are not at increased risk of pneumonia or other lower respiratory tract infections, contrary to findings from other international studies.
Our result suggests preoperative albumin level as an independent risk factor for PPCs in elderly gastric cancer (GC) patients after elective laparoscopic gastrectomy. We also suggest that those elderly hypoalbuminemic GC patients may benefit from more intensive perioperative care including perioperative nutritional status improvement.
Inflammatory bowel disease (IBD), an umbrella term for a number of gut disorders -- including ulcerative colitis and Crohn's disease -- remains a clinical challenge. Now, researchers from Sanford Burnham Prebys Medical Discovery Institute (SBP), in collaboration with scientists at Technion - Israel Institute of Technology, have identified a protein that drives intestinal inflammation. This finding highlights new opportunities for creating targeted therapeutics. The study published today in Cell Reports.