Investigators at the National Institutes of Health (NIH) and international colleagues have discovered a genetic cause and potential treatment strategy for a rare immune disorder called CHAPLE disease. Children with the condition can experience severe gastrointestinal distress and deep vein blood clots. No effective treatments are available to ameliorate or prevent these life-threatening symptoms.
Acute and chronic infections in a person's upper gastrointestinal tract appear to be linked to Parkinson's disease, say scientists at Georgetown University Medical Center and their collaborators at the National Institutes of Health and other institutions.
Although genetic risk factors for rheumatoid arthritis are known, little is understood about the environmental factors that contribute to the disease. This week in the JCI, a study led by Annalisa Pianta at Massachusetts General Hospital has identified autoimmune responses to two gut-derived bacterial proteins in the joint fluid of rheumatoid arthritis patients, suggesting a causal link between intestinal and joint autoimmunity.
Researchers at Case Western Reserve University School of Medicine have shown a high fat diet may lead to specific changes in gut bacteria that could fight harmful inflammation -- a major discovery for patients suffering from Crohn's disease. Crohn's disease, a type of inflammatory bowel syndrome, causes debilitating intestinal swelling, cramping, and diarrhea. The disease affects half a million people in the United States, but its cause is yet unclear.
Scientists used human pluripotent stem cells to generate human embryonic colons in a laboratory that function much like natural human tissues when transplanted into mice, according to research published June 22 in Cell Stem Cell. The study is believed to be the first time human colon organoids have been successfully tissue engineered in this manner, according to researchers who led the project.
A microscopic fungus called Candida tropicalis triggered gut inflammation and exacerbated symptoms of Crohn's disease, in a recent study conducted at Case Western Reserve University School of Medicine.
In its latest recommendations, the US Multi-Society Task Force (MSTF) on Colorectal Cancer (CRC) Screening confirms that people at average risk should be screened beginning at age 50, and recommends colonoscopy and fecal immunochemical testing (FIT) as the 'first tier' screening tests for this group. Screening continues to be a first line of defense against CRC, as it can detect pre-cancerous growths as well as cancer, which is highly treatable if caught early.
Researchers have for the first time discovered that a specific type of irritable bowel syndrome is associated with exhaustion of the immune system in patients.
In the days following abdominal surgery, patients' intestinal contents pass more slowly or not at all. New research at KU Leuven (University of Leuven), Belgium, has now shown that this phenomenon -- known as post-operative ileus or bowel paralysis -- is not caused by the cells previously identified as the main players. Quite the opposite, in fact: the cells even help restore bowel function. The findings are very important for further research into post-operative patient treatment.
Therapies to change the bacteria in the gut, through diet, pro-and prebiotic supplements, faecal matter transplants or antibiotics, could treat autism. A review of six decades of research linking the gut to brain development could pave the way for cheap and effective treatment.