Patients who underwent cold snare polypectomy for small polyps while continuing to take anticoagulants did not experience increased incidence of severe bleeding compared with those who underwent hot snare polypectomy with heparin bridging. Findings from a multicenter, randomized, controlled trial are published in Annals of Internal Medicine.
Scientists from NTU Singapore have developed a type of molecular renal probe that 'lights up' upon detecting the molecular changes caused by the onset of acute kidney failure. These probes could potentially be used in test strips for urine samples, making it a non-invasive method of detecting acute kidney failure.
Nearly 10 years ago, a group of Israeli clinical researchers emailed Berkeley Lab geneticist Len Pennacchio to ask for his team's help in solving the mystery of a rare inherited disease that caused extreme, and sometimes fatal, chronic diarrhea in children. Now, following an arduous investigative odyssey that expanded our understanding of regulatory sequences in the human genome, the multinational scientific group has announced the discovery of the genetic explanation for this disease.
Japanese scientists at Toho University in Tokyo discovered a new mechanism to generate regulatory T cells (Treg cells), lymphocytes preventing autoimmunity and excess immune responses. They found that a gene called JunB mediates signaling of the cytokine interleukin-2 (IL-2) to facilitate generation of Treg cells, raising the possibility that JunB might be a target to expand Treg cells.
Scientists at McMaster University have identified new biomarkers for Irritable Bowel Syndrome (IBS) in urine, which could lead to better treatments and reduce the need for costly and invasive colonoscopy procedures currently used for diagnosis.
Depression is common in people with inflammatory bowel disease (IBD), but the actual causes of depression in this group are unknown. In a Neurogastroenterology & Motility study, depression was linked with more severe IBD symptoms, and a less positive cognitive bias in emotional recognition (a reduced ability to recognize basic emotions in others) was involved in this association.
Medications that target tumor necrosis factor alpha (TNFα), a protein involved in inflammation, have revolutionized the management of certain autoimmune diseases, but paradoxically, these agents might provoke the development of other autoimmune conditions.
In humans, the gut microbiome is an ecosystem of hundreds to thousands of microbial species living within the gastrointestinal tract, influencing health and even longevity. As interest in studying the microbiome continues to increase, understanding this complexity will give us predictive power to engineer it. A research team led by Carnegie's Will Ludington built a rigorous mathematical framework that describes the ecology of a microbiome coupled to its host.
Toronto scientists have uncovered a metabolic pathway that only exists in parasitic worms. This will allow development of drugs that target parasites only without harming the human host.
NETRF-funded researchers identified a cancer cell type that is associated with non-functional pancreatic neuroendocrine tumor (pNET) recurrence. Alpha-like pNET cell expression of the protein ARX can guide prognosis.