A study published today in PLOS ONE discovered the origin of severely disfiguring masses of cells, called neurofibromas, that gradually develop throughout the skin of patients afflicted with Neurofibromatosis 1 (NF1). The discovery consisted of micro-lesions that contained small pathological clusters of nerve fibers and associated Schwann cells that proliferate to form the bulk of the disfiguring neurofibromas.
'This study shows that [rare pulmonary side effects of brigatinib] can disappear within days despite continued exposure to the drug,' says D. Ross Camidge, M.D., Ph.D.
Fasting from dawn to sunset for 30 days increased levels of proteins that play a crucial role in improving insulin resistance and protecting against the risks from a high-fat, high-sugar diet, according to research presented at Digestive Disease Week® (DDW) 2019. The study, which was based on the fasting practices of Ramadan, a spiritual practice for Muslims, offers a potential new treatment approach for obesity-related conditions, including diabetes, metabolic syndrome and non-alcoholic fatty liver disease (NAFLD).
Increased use of primary care may reduce rates of respiratory failure and admissions to the intensive care unit, according to research presented at ATS 2019.
African-American patients with chronic obstructive pulmonary disease, or COPD, are less likely to participate in pulmonary rehabilitation programs than white patients, even when there are programs nearby.
Retinal vascular tortuosity, a microvascular abnormality of the eye, may provide doctors with a noninvasive way of determining the extent of vascular remodeling in patients with pulmonary arterial hypertension.
COPD patients who were given a pedometer and participated in a web-based intervention that helped them set physical activity goals, provided feedback and disease self-management education, and offered a community forum were less likely to experience an acute exacerbation of their lung disease than those patients who received only the pedometer, according to a randomized, controlled trial.
Medical University of South Carolina investigators have exploited a metabolic quirk of certain cancers known as glutamine addiction to identify a potential new therapy for esophageal cancer. After characterizing the pathway involved in cancer progression, they tested a new combination treatment in both cells and animal models, with promising results. The next step is to secure funding to bring the new combination regimen to clinical trial. Their findings are reported in Nature Communications.
MedStar Franklin Square is the first medical facility in the state to offer endoscopic lung volume reduction (ELVR), using a new FDA-approved lung valve that is positioned in damaged lung airways without surgery, and allows patients with severe emphysema to breathe easier.
Dr. Stuart J. Spechler among researchers from Baylor Scott & White Research Institute available to provide key takeaways from Digestive Disease Week 2019.