In proof-of-concept experiments, University of Alabama at Birmingham researchers have highlighted a potential therapy for a rare but potentially deadly blood-clotting disorder, TTP. The researchers deliver this therapeutic enzyme via the cellular equivalent of a Trojan Horse, using tiny blood cell platelets as their protective delivery vehicle, with a key enzyme hidden inside.
Diabetes is not the only disease on which insulin has an effect, it appears. In a new study that involved tests on mice researchers from the University of Copenhagen, among others, have discovered a new method for treating chronic colitis with regular insulin. The researchers have set up a company with a view to testing the treatment and hopefully making it available to patients.
Genomic screening of more than 50,000 people shows that more than 80 percent of those who carry an identifiable genetic risk for breast, ovarian, prostate, and pancreatic cancer don't know it despite frequent interaction with the healthcare system.
Burning wood or coal to cook food is associated with increased risk of hospitalization or dying from respiratory diseases, according to new research conducted in China and published online in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.
A study conducted in Simon Fraser University's hypobaric chamber has sealed Air Canada's decision to allow pilots to sport facial hair.
A Loyola Medicine study demonstrates that an educational curriculum for resident physicians improves their emotional intelligence, which may help protect against burnout. Physician burnout has reached alarming levels, with one study finding it affects at least half of all doctors.
With an estimated 1.6 million people in the US dealing with inflammatory bowel disease (IBD), physicians can have a hard time telling which newly diagnosed patients have a high risk of severe inflammation or what therapies will be most effective. Now researchers report in the journal JCI Insights finding an epigenetic signature in patient cells that appears to predict inflammation risk in a serious type of IBD called Crohn's disease.
Searching for a more direct connection between the gut and the brain, Duke researchers were shocked to see that distance spanned by a single synapse, relaying the signal in less than 100 milliseconds, less than the blink of an eye. The finding in the journal Science has profound implications for the understanding of appetite and appetite suppressants, most of which target slow-acting hormones rather than fast-acting synapses.
Researchers have identified an independent prognostic factor, cancer/testis antigen 45, that is associated with extended disease-free survival for women with advanced ovarian cancer. Patients with high levels of CT45 in their tumors lived more than seven times as long as patients who lacked sufficient CT45.
Scientists working to bioengineer the entire human gastrointestinal system in a laboratory now report using pluripotent stem cells to grow human esophageal organoids. The newly published research in the journal Cell Stem Cell is the first time scientists have been able to grow human esophageal tissue entirely from pluripotent stem cells (PSCs), which can form any tissue type in the body.