Immune responses and the regulation of autoimmunity are affected by the time of day when the response is activated. There may be important differences in time-of-day response to drugs used to treat autoimmune diseases such as multiple sclerosis.
Each year there are more than three million cases of cholera worldwide. Research at the University of Maryland School of Medicine now shows that giving a stronger single-dose of a live oral vaccine could be an effective tool in controlling outbreaks more quickly.
An alternative animal model that mimics key features of the Zika virus infection, including its lingering presence in bodily fluids, has been developed at Texas Biomedical Research Institute in San Antonio.
Although the insidious bacterium Salmonella typhi has been around for centuries, very little is actually known about its molecular mechanisms. A new study from researchers at the College of Veterinary Medicine addresses this knowledge gap and may lead to novel, targeted treatments.
Analyzing trends on Twitter and Google can help predict vaccine scares that can lead to disease outbreaks, according to a study from the University of Waterloo.
A species of fungus that lives in the gut of some Aedes aegypti mosquitoes increases the ability of dengue virus to survive in the insects, according to a study from researchers at Johns Hopkins Bloomberg School of Public Health.
More than 90 percent of study volunteers in the 3 trials who received the investigational vaccine demonstrated an immune response to Zika virus.
An analysis of HPV in men shows that infection with one type strongly increased the risk of reinfection of the same type. The study highlights the importance of vaccination for preventing the spread of HPV in young men before they become sexually active and in older men who have already contracted the virus.
Three Phase 1 human clinical trials evaluating an Army-developed Zika purified inactivated virus (ZPIV) vaccine have shown it was safe and well-tolerated in healthy adults and induced a robust immune response. Initial findings from the trials were published today in The Lancet.
Healthy adults mounted strong immune responses after receiving an investigational whole inactivated Zika virus vaccine, according to interim analyses of three Phase 1, placebo-controlled, double-blind trials conducted at Beth Israel Deaconess Medical Center (BIDMC), Walter Reed Army Institute of Research (WRAIR), and Saint Louis University School of Medicine. The findings were published today in The Lancet.