Quality of life for people with type 1 diabetes who had frequent severe hypoglycemia -- a potentially fatal low blood glucose leve -- improved consistently and dramatically following transplantation of insulin-producing pancreatic islets, according to findings published online March 21 in Diabetes Care. The results come from a Phase 3 clinical trial funded by the National Institute of Allergy and Infectious Diseases (NIAID) and the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).
New research from scientists at the La Jolla Institute shows how a diet high in fat and cholesterol depletes the ranks of artery-protecting immune cells, turning them into promoters of inflammation, which exacerbate atherosclerotic plaque buildup that occurs in cardiovascular disease. The team has also found that high density lipoproteins (HDL)--more commonly known as "good cholesterol"--counteract this process, helping the protective immune cells maintain their identity and keep arteries clear.
New findings in mice suggest that the lack of a copy of the gene MVP may contribute to the symptoms of 16p11.2 deletion syndrome because it is needed for brain circuits to incorporate changes driven by experience.
Researchers have identified a 'genetic fingerprint' associated with the most deadly strains of malaria parasites, making these unique DNA regions potential targets for vaccine development.
A new report finds that extremely obese people who have a band surgically strapped around their stomachs to restrict food intake not only lose weight but also suffer less from arthritic knee pain.
Researchers have identified a therapeutic target to prevent or delay heart failure from pressure overload of the heart, and a potential biomarker for the same. They say their animal studies carry clinical and translational potential. Mouse-model experiments showed that preventing the early infiltration of CCR2+ macrophages into the heart, after experimental pressure overload, significantly lessened the heart's enlargement and reduced pumping ability that leads to later heart failure.
In January 2017 guidelines were released urging parents to begin early introduction of peanut-containing foods to reduce the risk of peanut allergy. A new study shows those who are aware of the guidelines are still hesitant to put them into place and not everyone has heard of them.
Children with mild to moderate asthma do not benefit from a common practice of increasing their inhaled steroids at the first signs of an asthma exacerbation, according to clinical trial results published in The New England Journal of Medicine. Researchers found short-term increases in inhaled steroids did not prevent attacks in children aged 5 to 11, and may even slow a child's growth.
Scientists are bringing precision medicine to rheumatoid arthritis for the first time by using genetic profiling of joint tissue to see which drugs will work for which patients, reports a new multi-site study. In the near future, patients won't have to waste time and be disappointed with months of ineffective therapy, scientists said. Currently $2.5 billion a year is wasted on therapy that doesn't work.
Scientists have discovered a human antibody that, when tested in mice, prevented malaria infection by binding a specific portion of a surface protein found in almost all strains of the malaria parasite worldwide.