In proof-of-concept experiments, University of Alabama at Birmingham researchers have highlighted a potential therapy for a rare but potentially deadly blood-clotting disorder, TTP. The researchers deliver this therapeutic enzyme via the cellular equivalent of a Trojan Horse, using tiny blood cell platelets as their protective delivery vehicle, with a key enzyme hidden inside.
Diabetes is not the only disease on which insulin has an effect, it appears. In a new study that involved tests on mice researchers from the University of Copenhagen, among others, have discovered a new method for treating chronic colitis with regular insulin. The researchers have set up a company with a view to testing the treatment and hopefully making it available to patients.
Researchers from the University of Oxford's Department of Zoology have demonstrated pre-clinical success for a universal flu vaccine in a new paper published in Nature Communications.
A naturally occurring antibiotic called kanglemycin A is effective against Mycobacterium tuberculosis, the bacteria that cause tuberculosis, even in drug-resistant strains, according to an international team of researchers who used chemistry, molecular biology, microbiology, and X-ray crystallography to show how the compound maintains its activity.
Using a bioinformatics approach, University of California San Diego School of Medicine researchers found that CD4+ T cell's binding partner, a molecule called MHC-II, may have even more influence on emerging tumors than MHC-I, the better known partner of CD8+ T cells. The finding, published September 20 in Cell, may help researchers improve cancer immunotherapies and predict which patients will respond best.
Attention has focused on how NSAIDs may cause dysfunction of the immune system. Researchers now have found that sub-acute pretreatment with the NSAID carprofen before experimental heart attack in mice impaired resolution of acute inflammation following cardiac injury. They focused on three aspects of the inflammation resolution axis -- cardiac function, leukocyte profiling and inflammation-resolution markers.
In search of an option for the drug known for causing several side effects, scientists describe the anti-inflammatory properties of protein galectin-1 in tests with rats involving ischemia-reperfusion scenarios.
The STING protein is normally an important part of our immune system, but in some autoimmune diseases it is itself the source of the disease. The pharmaceutical industry is therefore engaged in a race to find a drug that can inhibit STING. Now, researchers from Aarhus may have found it.
During the month of July, a total of 758 cases of measles were reported across seventeen countries in the EU/EEA, which is a decrease from the 1054 cases reported during the month of June.
A novel study indicates promising avenues in an innovative approach for developing a vaccine against Plasmodium vivax, the most prevalent human malaria parasite outside sub-Saharan Africa. The study, led by researchers from the Barcelona Institute for Global Health, indicates the possibility of using small vesicles (or exosomes) secreted by immature red blood cells as a vaccine platform against malaria. The paper, carried out in collaboration with IrsiCaixa AIDS Research Institute, was published in Scientific Reports.