More than 90 percent of human papillomavirus (HPV)-related cancers could be prevented by widespread uptake of the HPV vaccine. Yet, vaccine use in the United States falls short of public health goals.
A team of zoologists and microbiologists from NUI Galway have published a new study showing that common house spiders carry bacteria susceptible to infect people, with the Noble False Widow spiders also carrying harmful strains resistant to common antibiotic treatments.
In lung tissue from a person who died after contracting COVID-19, active inflammasomes (puncta, represented as red specks) can be seen in some cells. Collagen fibers, lung cell nuclei and epithelial cells are stained green, blue and pink respectively
Meningococcus group B, the most prevalent strain of meningococcal infection, is prevented with 79 per cent effectiveness in children and young adults inoculated with the 4CMenB vaccine, also known as Bexsero, according to a new collaborative study from researchers in Portugal and the UK and led by the University of Bristol which evaluated the vaccine's performance in a real-world setting. The findings are published today [1 December] in the Journal of the American Medical Association (JAMA).
KU Leuven researchers published results of their vaccine candidate, a vector vaccine based on the yellow fever vaccine. The paper shows that the vaccine protects hamsters from infection with the SARS-CoV-2 coronavirus after a single dose. It is also effective in monkeys.
Researchers from the University of Tsukuba have shown that the skin fibrosis seen in chronic graft-versus-host disease is mediated by transforming growth factor-β1 expressed by epidermal cells undergoing programmed death when they are stimulated by interferon-γ. Further investigations elucidate the sclerodermatous changes characteristic of autoimmune and inflammatory conditions such as systemic sclerosis, discoid lupus erythematosus and toxic epidermal necrolysis, thus opening up research avenues in pharmacotherapeutics based on targeting apoptosis and interferon-γ.
The role of a protein in detecting the common cold virus and kickstarting an immune response to fight infection has been uncovered by a team of scientists from Nanyang Technological University, Singapore (NTU Singapore), the Agency for Science, Technology and Research (A*STAR) and the National University of Singapore.
White blood cells called cytotoxic T lymphocytes (CTLs) dig tunnels in tissues, potentially allowing other CTLs to quickly reach infected cells and tumor cells, researchers report December 1st in Biophysical Journal. The results show that some CTLs move slowly as they create channels through the extracellular matrix (ECM) - a major component of tissues. Afterward, other CTLs move quickly through the channels, presumably to efficiently search for and eliminate target cells.
The recent serious outbreak of Covid19 has required urgent medical treatments for numerous patients. No clinically active vaccines or antiviral agents are available for Covid19. According to several studies, Chloroquine (CQ) and Hydroxychloroquine (HCQ) have shown promises as Covid19 antiviral especially when administered with Azithromycin (AZM).
The findings, published in the online edition of Clinical Cancer Research on Nov. 4, 2020, suggest that BMS-986178, an investigational OX40 agonist, has an acceptable safety profile in patients with advanced solid tumors, whether used as monotherapy or in combination with the checkpoint inhibitors nivolumab (Opdivo®) and/or ipilimumab (Yervoy®).