News by Subject Medicine & Health

University of Colorado Cancer Center study shows that cancer-causing MLL gene may also push pluripotent stem cells to make hematopoietic stem cells, a strong step in the decades-long effort to make personalizable, durable blood stem cells.

A pilot study of 25 donor-recipient pairs reveals that healthy young donors of stem cells harbor previously undetected and potentially disease-causing mutations in their blood stem cells, which were transferred to unrelated recipients of the transplants.

Responders who worked at the World Trade Center site after the attacks on Sept. 11, 2001, have an increased overall cancer incidence compared to the general population, particularly in thyroid cancer, prostate cancer, and, for the first time ever reported, leukemia, according to a Mount Sinai study published in JNCI Cancer Spectrum in January.

People with metabolic syndrome -- a set of conditions including obesity, impaired glucose metabolism, elevated levels of fats and cholesterol in the blood, and high blood pressure - are more likely to experience recurrent blood clots, according to a new study published today in Blood Advances. Among patients diagnosed with a type of blood clot known as deep vein thrombosis (DVT), those who also had markers of metabolic syndrome were more likely to experience another venous thromboembolism (VTE) event.

A preliminary study has found that when young, healthy men were deprived of just one night of sleep, they had higher levels of tau, a biomarker for Alzheimer's disease, in their blood than when they had a full, uninterrupted night of rest. The study is published in the Jan. 8, 2020, online issue of Neurology®, the medical journal of the American Academy of Neurology.

A new study provides convincing evidence that the use of peripherally inserted central catheters (PICCs) to administer medicine and draw blood in children is associated with a significantly increased risk of blood clots (known as venous thromboembolism or VTE) compared with central venous catheters (CVCs) placed directly into the neck or chest.

In their analysis of blood pressure data, researchers focused on people aged 80 and older who had reported heart disease events (such as heart attacks or strokes), changes in kidney function, cognitive impairment, quality of life, or death. The researchers also explored whether impairments in cognitive or physical function had any effect on intensive blood pressure control. They published their results in the Journal of the American Geriatrics Society.

A breakthrough gene therapy treatment for Haemophilia A has been shown to offer long-term benefits that have already transformed the lives of 13 men in the UK.

The authors conclude the review with a summary of future perspectives, in which they discuss how newly developed techniques, like the deactivated-Cas9 (dCas9) gene-expression control system, can be utilized during the course of hematopoietic differentiation of pluripotent stem cells for precise temporal control of the aforementioned master regulators to achieve functional HSCs.