New Columbia study suggests current vaccines and monoclonal antibody therapies provide less neutralizing activity against the U.K. and South Africa variants of SARS-CoV-2.
A study published in the journal Scientific Reports, published by Nature, has gauged the impact of the measures taken during the first and second waves of the virus on citizens of three European Union countries (Spain, Italy and the United Kingdom). The study concludes that the shock produced by the situation has reduced people's cognitive capacity, leading them to take more risks, despite the risk of contagion, and make poorer choices, including a tendency to be less altruistic and the desire to punish others.
A new review of existing evidence proposes eight hallmarks of environmental exposures that chart the biological pathways through which pollutants contribute to disease: oxidative stress and inflammation, genomic alterations and mutations, epigenetic alterations, mitochondrial dysfunction, endocrine disruption, altered intercellular communication, altered microbiome communities, and impaired nervous system function.
University of Tsukuba researchers took an innovative approach to finding ways to increase road safety. Using 10 years of nationwide data on junior high school students commuting by bicycle, they found a sharp drop in road injuries where there's heavy snowfall. This likely owes to the students' 'modal shift' from cycling to, for instance, walking or public transportation. With high prevalence of road injuries and deaths worldwide, such modal shifting may help make roads safer.
Pandemic-related anxiety, boredom, and irregular routines were cited as major drivers of increased nicotine and tobacco use during the initial COVID-19 "lockdown," according to research just released by Columbia University Mailman School of Public Health. The study highlights ways that public health interventions and policies can better support quit attempts and harm reduction, both during the COVID-19 pandemic and beyond.
COVID?19 has altered the labor market for millions of people, including public health graduates, yet an analysis of job postings for Master's level public health graduates showed that job postings remained at the same levels as before the pandemic, according to a new study at Columbia University Mailman School of Public Health.
A deep sequencing study of 747 SARS-CoV-2 virus isolates has revealed mutant peptides derived from the virus that cannot effectively bind to critical proteins on the surface of infected cells and, in turn, hamper activation of CD8+ killer T cells that recognize and destroy these infected cells.
A new study employing ancient human DNA reveals how tuberculosis has affected European populations over the past 2,000 years, specifically the impact that disease has had on the human genome. This work, which publishes March 4 in the American Journal of Human Genetics, has implications for studying not only evolutionary genetics, but also how genetics can influence the immune system.
Specialists in viral and genetic analysis, led by Swiss scientists Dr. Emma Hodcroft at the University of Bern and Prof. Christophe Dessimoz at University of Lausanne, alongside Dr. Nick Goldman at EMBL-EBI in the UK, lay out the 'bioinformatics bottlenecks' that are hindering response to the SARS-CoV-2 pandemic, and propose ways to 'clear the road' for better tools and approaches.
he clinical picture of COVID-19 in various target organs has been extensively studied and described, but relatively little is known about the characteristics of oral cavity involvement. The study "Frequent and Persistent Salivary Gland Ectasia and Oral Disease After COVID-19" published in the Journal of Dental Research (JDR), investigated the presence and prevalence of oral manifestations in COVID-19 survivors.