Exercise has been touted to build bone mass, but exactly how it actually accomplishes this is a matter of debate. Now, researchers show that an exercise-induced hormone activates cells that are critical for bone remodeling in mice. A study appearing in Cell on identifies a receptor for irisin, an exercise hormone, and shows that irisin impacts sclerostin in mice, a major cellular regulator of bone structure in humans.
"Treatment with active vitamin D did not decrease cardiovascular events in kidney patients undergoing hemodialysis"-- A research group in Japan reported their research results in the December 11 issue of JAMA. "Death risk did not decrease either", according to the principal investigator Dr. Tetsuo Shoji, Research Professor at Department of Vascular Medicine, Osaka City University Graduate School of Medicine, Japan.
For people with Type 2 diabetes, testing blood sugar levels becomes part of everyday life. But a new study suggests that some of them test more often than they need to. Fourteen percent of people with Type 2 diabetes who don't require insulin are buying enough test strips to test their blood sugar two or more times a day -- when they don't need to test nearly that frequently according to medical guidelines.
New research from the University of Adelaide's Robinson Research Institute supports the need for dietary and lifestyle interventions before overweight and obese women become pregnant.
A team of researchers at Baylor College of Medicine and the University of Michigan Medical School reports that a subset of immune B cells, known as CD19+IgM+ B cells, can delay the onset of type 1 diabetes in a mouse model of the condition.
Hysterectomy can impair some types of memory in the short term following the surgery, according to a rat study published in the Endocrine Society's journal Endocrinology.
A team of Stanford University endocrinologists and chemists has taken a step toward targeting the cells in the pancreas that produce insulin more precisely, using a property that researchers have long known about but never exploited for treatment: Beta cells, the insulin-producing cells in the pancreas, have a particularly strong taste for zinc.
The non-pregnant uterus is commonly assumed to be an unimportant organ. One third of American women have a hysterectomy by age 60, often before natural menopause. Arizona State University researchers have found an animal model of hysterectomy resulted in decreased memory capacity and an altered hormonal profile within two months after surgery. The study suggests an important role for the uterus that could impact cognitive aging.
Restoring the action of insulin is one of the keys to fighting type 2 diabetes. Researchers from Inserm led by Dominique Langin at the Institute of Cardiovascular and Metabolic Diseases (Inserm/Université de Toulouse) are developing a therapeutic strategy that uses the properties of an enzyme (hormone-sensitive lipase) which, when stimulating fatty-acid synthesis in the fat cells, has a beneficial effect on insulin action. This research has been published in Nature Metabolism.
Previous studies have demonstrated that fetal malnutrition can lead to adult chronic disorders such as type 2 diabetes and coronary artery disease. A new study out of China now suggests that it also can lead to early menopause and premature ovarian failure. Results are published online today in Menopause, the journal of The North American Menopause Society (NAMS).