New evidence points to a key role for a molecular switch called VGLL3 in autoimmune diseases, and the major gap in incidence between women and men. Building on past research showing that women have more VGLL3 in their skin cells than men, a team studied it further in mice. They show that having too much VGLL3 in skin cells pushes the immune system into overdrive, leading to an autoimmune response and symptoms similar to lupus.
Whether a wound -- such as a diabetic foot ulcer -- heals or progresses to a worse outcome, including infection or even amputation, may depend on the microbiome within that wound.
Treg cells turn off the immune system. Three recent studies show that targeting tregs may increase the effectiveness of anti-cancer immunotherapies.
A new study suggests that sunscreen protects the skin's blood vessel function from harmful ultraviolet radiation (UVR) exposure by protecting dilation of the blood vessels. Perspiration on the skin may also provide protection to the skin's blood vessels from sun damage. The findings will be presented today at the American Physiological Society's (APS) annual meeting at Experimental Biology 2019 in Orlando, Fla.
Mass drug administration of two antibiotics can be highly effective at reducing cases of scabies and the bacterial infection impetigo, according to new research published in Lancet Infectious Diseases.
A group of medical students recruited to improve Wikipedia articles on skin-related diseases, saw millions more views of those stories following their editing, highlighting the value of expert input on the popular web encyclopedia.
Application of sun protection factor (SPF) moisturizers tends to miss more of the face, especially around the eyelid regions, compared with sunscreen application, according to a study published April 3 in the open-access journal PLOS ONE by Kevin Hamill of the University of Liverpool, and colleagues. Moreover, people applying these products are unaware that they are failing to cover regions vulnerable to skin cancer.
University of Colorado Cancer Center study presented at AACR 2019 shows that tumors with mutations in genes leading to over-activation of the NF-kB signaling pathway were more than three times as likely to respond to anti-PD1 immunotherapy compared with tumors in which these changes were absent.
Hairlessness in dogs can be the result of deliberate breeding or, in certain breeds, a defect. A recent study completed at the University of Helsinki describes a gene variant in the SGK3 gene, which causes hairlessness in Scottish deerhounds. The gene defect results in puppies born with thin fur that lose all of their hair in a few weeks. SGK3 is also a candidate for association with non-hormonal baldness in humans.
Pathogenic gene mutations causing a type of intractable skin disease can be eliminated from some parts of patients' skin as they age, according to Hokkaido University researchers and their collaborators in Japan. This represents a form of natural gene therapy.