News by Subject Medicine & Health

Researchers from the University of Tsukuba have shown that the skin fibrosis seen in chronic graft-versus-host disease is mediated by transforming growth factor-β1 expressed by epidermal cells undergoing programmed death when they are stimulated by interferon-γ. Further investigations elucidate the sclerodermatous changes characteristic of autoimmune and inflammatory conditions such as systemic sclerosis, discoid lupus erythematosus and toxic epidermal necrolysis, thus opening up research avenues in pharmacotherapeutics based on targeting apoptosis and interferon-γ.

A new study from researchers at the University of California, Davis, finds eating Ataulfo mangoes, also known as honey or Champagne mangoes, may reduce facial wrinkles in older women with fairer skin. But too much mango may increase wrinkles.

How do we shrink persistent racial health disparities, especially among children? Dell Medical School's Elizabeth Matsui says it starts by applying an antiracist blueprint to guide the way we fund, evaluate and disseminate research.

New research from the University of North Carolina School of Medicine and the Lineberger Comprehensive Cancer Center found immunotherapies effective against lung cancer and melanoma may work against cutaneous angiosarcoma, a rare, highly aggressive skin tumor found primarily on the scalps of older White people. The researchers report tumor-infiltrating lymphocytes and the surface protein markers PD-1 and PD-L1 could help guide the choice of immunotherapy to fight cutaneous angiosarcomas.

A vaccine created to prevent the recurrence of the deadly skin cancer melanoma is about twice as effective when patients also receive two components that boost the number and effectiveness of immune system cells called dendritic cells, according to phase 2 clinical trial results published in Nature Cancer in November.