A surprising form of cell-to-cell communication in glioblastoma promotes global changes in recipient cells, including aggressiveness, motility, and resistance to radiation or chemotherapy. Paradoxically, the sending cells in this signaling are glioblastoma cells undergoing programmed cell death. The apoptotic cancer cells release extracellular vesicles. These vesicle, or exosomes, carry components that alter RNA splicing in the recipient glioblastoma cells, and this altered splicing promotes therapy resistance and aggressive migration.
Survivors of opioid overdose are at great risk of dying in the year after overdose, but the deaths are not always caused by drug use, a new study reveals. In addition to succumbing to drug use, survivors were much more likely to die from respiratory diseases, viral hepatitis, and suicide.
Adults who survive an opioid overdose are at high risk of dying during the year after the incident of substance use-associated diseases, suicide and other medical conditions.
A National Institutes of Health-funded study found that treatment of opioid use disorder with either methadone or buprenorphine following a nonfatal opioid overdose is associated with significant reductions in opioid related mortality. The research, published today in the Annals of Internal Medicine, was co-funded by the National Institute on Drug Abuse (NIDA) and the National Center for Advancing Translational Sciences, both parts of NIH.
Covers the assassination of Robert F. Kennedy. The authors 'review the eyewitness reports of the mechanism of injury, the care rendered for three hours prior to the emergency craniotomy, the clinical course, and, ultimately, the autopsy.' The discussion of autopsy findings is supplemented by an artist's depiction of the extent of Senator Kennedy's head injury.
The risk of mortality, and of developing a number of cancers, is lowest in light drinkers consuming an average of less than one drink per day across their lifetime, and the risk of some cancers increases with each additional drink per week, according to a new study, published this week in PLOS Medicine by Andrew Kunzmann of Queen's University Belfast, and colleagues.
The average 10-year risk of developing cardiovascular disease varies widely among India's states, ranging from 13.2 percent to 19.5 percent, with substantial variation across socio-demographic groups according to a study published this week in PLOS Medicine by Pascal Geldsetzer and Rifat Atun of Harvard University, and colleagues.
new study out of Boston Medical Center's Grayken Center for Addiction on opioid overdose survivors indicates that two FDA approved medications to treat opioid use disorder save lives, but only three out of 10 overdose survivors receive them.
Forty percent of deaths attributed to cardiac arrest are not sudden or unexpected, and nearly half of the remainder are not arrhythmic -- the only situation in which CPR and defibrillators are effective -- according to an analysis by researchers at UC San Francisco and the City and County of San Francisco Office of the Chief Medical Examiner.
A combination of elevated fasting glucose and HbA1c levels from a single blood sample was found to be accurate for diagnosing diabetes. This is significant because current guidelines state that a second blood test, conducted a separate point in time, is requited to confirm a diagnosis of diabetes. Findings from a prospective cohort study are published in Annals of Internal Medicine.