The Pediatric NEXUS Head Computed Tomography (CT) Decision Instrument (DI) reliably identifies blunt trauma patients who require head CT imaging and could significantly reduce the use of CT imaging.
Improved medications for Type 2 diabetes are one step closer thanks to a new discovery reported this week by researchers at the University of Pennsylvania and Syracuse University. By modifying the key ingredient in current diabetes drugs, the researchers produced a compound that was effective for hyperglycemia in animal trials, yet without the most problematic side effects of current drugs.
Yale researchers have tested a new method for directly measuring synaptic loss in individuals with Alzheimer's disease. The method, which uses PET imaging technology to scan for a specific protein in the brain linked to synapses, has the potential to accelerate research for new Alzheimer's treatments, the researchers said.
Initial results of a new national clinical trial show that the majority of women with breast cancer who have two to three sites of disease in a single breast at the time of diagnosis are able to successfully complete breast-conserving surgery without conversion to mastectomy. This is the first prospective study to assess this possibility, and its findings improve the surgical choices available to women with multiple ipsilateral breast cancer.
Aeras, a nonprofit organization dedicated to developing vaccines against tuberculosis (TB), today announced the publication of the full results from a Phase 2, randomized, controlled clinical trial of two TB vaccines-- the currently available BCG vaccine and an investigational vaccine, H4:IC31--in the New England Journal of Medicine (NEJM).
Commercial insurance medical policies that do not cover treatment with proton therapy can make it difficult for patients to participate in randomized clinical trials funded by the NCI, part of the National Institutes of Health, that are evaluating the therapy.
Peer-reviewed / Randomised Controlled Trial / People Psychological therapy delivered by a virtual reality coach can help people with a clinically diagnosed fear of heights overcome their fear, according to a randomised controlled trial of 100 people published in The Lancet Psychiatry journal.
When conducting research involving the testing of human biospecimens, investigators and their institutions should routinely consider whether and how to return individual research results on a study-specific basis through an informed decision-making process, says a new report from the National Academies of Sciences, Engineering, and Medicine. Decisions on whether to return individual research results will vary depending on the characteristics of the research, the nature of the results, and the interests of participants.
Of 57 patients treated, 48 percent responded to the combination, with cancer control of median 8.2 months.
Personalized medicine -- delivering therapies specially tailored to a patient's unique physiology -- has been a goal of researchers and doctors for a long time. New research provides a way of delivering personalized treatments to patients with neurological disease.