A multicenter study reports that clot perviousness, or permeability - the ability for contrast used during the initial imaging workup to seep through a clot, as estimated by CT imaging - is associated with "first-pass success" in large vessel occlusion (LVO) strokes initially treated with an aspiration thrombectomy approach. LVO stroke treatment success using a stent retriever-first approach to remove the brain vessel blockage was less dependent on clot perviousness.
Batten disease is a group of fatal, inherited lysosomal storage disorders that predominantly affect children. The most prevalent form is CLN3 disease, for which there is no cure. Retinal degeneration and resulting vision loss is one of the symptoms.
Just as redeploying a fleet of small British fishing boats helped during the Battle of Dunkirk, marshalling the research equipment and expertise of the many agtech labs around the world could help combat pandemics, say the authors of a just-published article in Nature Biotechnology. Sophisticated agtech labs and equipment used for crop and animal breeding, seed testing, and monitoring of plant and animal diseases could easily be adapted for diagnostic testing and tracing in a human pandemic or epidemic, the article states.
New findings show that reducing the amount of protein in the urine of patients with focal segmental glomerulosclerosis can significantly slow declines in kidney function and extend time before patients' kidneys fail.
University of Toronto Engineering researchers have discovered a dose threshold that greatly increases the delivery of cancer-fighting drugs into a tumour.
A new study in Nucleic Acids Research suggests a possible effective treatment strategy for patients suffering from prion disease.
The interim analysis of ORIENT-11, a phase III double-blind randomized trial has shown a nearly two-fold increase in progression-free survival with addition of sintilimab to chemotherapy in patients with advanced or metastatic non-squamous non-small cell lung cancer without EGFR or ALK genomic aberrations, according to research data presented today at the International Association for the Study of Lung Cancer Virtual Presidential Symposium.
Patients with non-small cell lung cancer (NSCLC) carrying anaplastic lymphoma kinase (ALK) gene alterations who received ensartinib experienced substantially longer progression-free survival than a matched group of patients who received crizotinib.
The combination of first-line nivolumab and ipilimumab demonstrated an improvement of overall survival for patients with unresectable malignant pleural mesothelioma compared to platinum-based chemotherapy, according to research presented today at the International Association for the Study of Lung Cancer Virtual Presidential Symposium.
Expanding standard techniques during mechanical thrombectomy -- a procedure that removes a clot from an artery during stroke -- allows researchers to reproducibly obtain and study local leukocyte populations during human stroke, according to a study by the University of Kentucky Department of Neurology, released today at the Society of NeuroInterventional Surgery's (SNIS) 17th Annual Meeting.