CRISPR 'genetic screens' and new approaches to drug design have provided a potential new therapy, which blocks the progression of synovial sarcoma tumors in pre-clinical trials.
An initial screening tool can be used effectively in a busy, inner?city emergency department to identify child sex trafficking victims presenting with high?risk health complaints.
Controlled ingestion of peanut protein could help build tolerance in peanut allergy sufferers. Authors of a new study published in the New England Journal of Medicine say an oral immunotherapy drug they tested could be the first FDA-approved medication of its kind for people with peanut allergy. The medication, called AR101, is derived from peanut protein.
Both aspirin and a purified omega-3, called EPA, reduce the number of pre-cancerous polyps in patients found to be at high risk of developing bowel cancer, according to new research.
Mice are resistant to immunomodulatory drugs (IMiDs). As a result, studying the effects of IMiDs was not possible in existing types of mice. Here, an Osaka University-led research team, generated a new type of mouse that responds to IMiD treatment. This new mouse model allows assessment of the therapeutic effects of drugs that may be toxic to humans. If effective, such drugs could potentially provide sources of new immunomodulatory therapies.
Myotubular myopathy is a severe genetic disease that leads to muscle paralysis. Although no treatment currently exists, researchers from the UNIGE-with the University of Strasbourg,- have identified a molecule that not only greatly reduces the progression of the disease but also boosts life expectancy in animal models by a factor of seven. Since the molecule -- known as tamoxifen -- is already used for breast cancer, the researchers hope to soon set up a clinical trial.
Nightmares and insomnia often accompany posttraumatic stress disorder and increase suicide risk.
Many older patients who are considered frail by medical standards receive anticoagulants (blood thinners) and undergo cardiac catheterization during a heart attack. While these treatments can be helpful, they also can cause major bleeding, and frailty is an important bleeding risk factor according to a study published today in in JACC: Cardiovascular Interventions.
Study confirms biological mechanism responsible for latent HIV reservoirs; suggests strategies for a functional HIV cure.
For the first time scientists have identified how to halt kidney disease in a life-limiting genetic condition, which may pave the way for personalised treatment in the future.