The first randomized trial of its kind was unable to establish non-inferiority of oral anticoagulation (OAC) alone to combined OAC and a single antiplatelet agent (APT) in patients with atrial fibrillation (AF) and stable coronary artery disease beyond one year after stent implantation.
Results from the Lipid-Rich Plaque (LRP) study demonstrate the correlation between the presence of non-flow-limiting, non-intervened upon, lipid-rich plaques detected by NIRS-IVUS imaging and the development of a major adverse cardiac event (MACE) from a de novo culprit lesion at both the patient level (vulnerable patients) and segment level (vulnerable plaques) within 24 months post intravascular imaging.
The first study designed to determine the benefits of intravascular ultrasound (IVUS) guidance over angiography guidance during drug-eluting stent (DES) implantation in all-comer patients found that IVUS improved clinical outcomes by lowering the rate of target vessel failure at one year.
Women diagnosed with non-small cell lung cancers live longer than their male counterparts, according to results of a SWOG study presented today at the International Association for the Study of Lung Cancer's 19th World Conference on Lung Cancer in Toronto, Ontario, Canada.
Results of phase 1 and phase 2 clinical trials of the drug entrectinib in ROS1-positive non-small cell lung cancer (NSCLC) presented on the press program of the International Association for the Study of Lung Cancer (IASLC) 19th World Conference on Lung Cancer show a response rate of 77.4 percent for 53 patients evaluable for response, with median duration of response of 24.6 months.
The first large, randomized trial comparing a novel polymer-free amphilimus-eluting stent to the latest-generation permanent polymer drug-eluting stent found that the polymer-free stent was clinically safe and effective.
This first randomized clinical study of a polymer-coated zotarolimus-eluting stent (Resolute Onyx) that utilizes a novel thin-strutted metallic platform allowing for better x-ray visibility was shown to be non-inferior to an ultrathin-strutted bioresorbable polymer-coated sirolimus-eluting stent (Orsiro) that uses a cobalt-chromium strut platform.
'Our results indicate that frontal neurobehavioral symptoms may be predictive of the ability to achieve and maintain employment after TBI,' said Dr. Weber, lead author, and a research scientist at Kessler Foundation. 'Developing rehabilitative strategies that address these behaviors could improve employment outcomes,' she noted, 'and reduce the burden of care on caregivers and society.'
Exercise and physical activity are of vast global importance to prevent and control the increasing problem of heart disease and stroke, according to a review paper published today in the Journal of the American College of Cardiology. This paper is part of an eight-part health promotion series where each paper will focus on a different risk factor for cardiovascular disease.
A breakthrough has been made in the fight against Alzheimer's disease -- researchers have found a new way to target the toxic particles that destroy healthy brain cells. Academics at the University of Cambridge and at Lund University in Sweden have devised the first strategy to 'go after' the cause of the devastating disease, leading to hope that new drugs could be developed to treat dementia.