* High-level vaccine efficacy of 77% in African children achieve WHO-specified efficacy goal of 75% * Vaccine, trialled in 450 children, shows favourable safety profile and was well-tolerated * Vaccine candidate, R21/Matrix-M, has excellent potential for large-scale manufacturing and low-cost supply
The results of the Phase I NRG-BR001 trial, conducted by the NCI National Clinical Trials Network group NRG Oncology, indicate that stereotactic body radiotherapy (SBRT) treatment in standard doses was safe for 35 evaluable patients with a median of 3 metastases. There were no dose-limiting toxicities and over 50% of trial participants were alive at 2 years following treatment.
A new study has highlighted that while much is known about the ever increasing uptake of antidepressant medications around the world, there is very little evidence on safe and effective approaches to discontinuing treatment.
Penn Medicine researchers discovered that less is more when it comes to the length of what is known as the single-chain variable fragment for CAR T cells.
In a phase 1 clinical trial to evaluate the safety of the approach, UChicago Medicine researchers found that high-powered, tightly-targeted radiation therapy is safe for treating patients with multiple metastases.
What The Study Did: Researchers investigated racial/ethnic representation in clinical trials that led to U.S. Food and Drug Administration approval of ophthalmology drugs from 2000 to 2020.
What The Study Did: This review of 125 U.S.-based clinical trials that investigated the management of hearing loss assessed representation in the trials by race/ethnicity and sex.
In the first clinical trial of nicotinamide mononucleotide (NMN), researchers at Washington University School of Medicine in St. Louis have found that the compound previously demonstrated to counteract aspects of aging and improve metabolic health in mice also has clinically relevant effects in people.
A test which uses artificial intelligence (AI) to measure proteins present in some patients with advanced bowel cancer could hold the key to more targeted treatment, according to research published today.
A new analysis of data from a randomised controlled trial of the stop-smoking drug varenicline (brand name Chantix in the US and Champix elsewhere), has provided clear evidence that varenicline does not increase the risk of psychiatric problems.