Billions of US taxpayer dollars have been invested in Africa over the past 15 years to improve care for millions suffering from the HIV/AIDS epidemic; yet health systems on the continent continue to struggle. What if the investments and lessons learned from HIV could be used to improve care for those with other serious chronic conditions?
Researchers at The Scripps Research Institute recently published a study in the journal Cell Death and Differentiation identifying factors crucial to mesenchymal stem cell differentiation, providing insight into how these cells should be studied for clinical purposes.
Localized gene delivery to diseased joints to achieve sustained drug production at the site of osteoarthritis or rheumatoid arthritis is gaining momentum, with clinical trials underway in the US and the first arthritis gene therapy recently approved in Korea.
Overall survival has improved for the approximately 200,000 patients experiencing in-hospital cardiac arrest in the US each year, but patients who arrest during nights or weekends continue to experience lower survival compared to patients who arrest during daytime hours. Survival to discharge in patients who arrested during 'off-hours' was an absolute 3.8 percent lower compared to patients who arrested during 'on-hours,' according to a study published today in the Journal of the American College of Cardiology.
A USC study suggests regular exercise could add to the life expectancy of breast cancer survivors because it lowers their heightened risk of cardiovascular disease, Type 2 diabetes and possibly breast cancer recurrence. 'Many people don't know the No. 1 cause of death for breast cancer survivors is heart disease, not cancer,' said Christina Dieli-Conwright, lead author of a study published in the Journal of Clinical Oncology on Jan. 22.
Among patients older than 80 years, 3.9 percent receiving surgery passed away within the 30-day post-treatment window, compared with 0.9 percent of patients receiving focused radiation.
The results from the largest ever study of septic shock could improve treatment for critically ill patients and save health systems worldwide hundreds of millions of dollars each year. Researchers at The George Institute for Global Health studied whether the use of steroids as an additional treatment to septic shock -- a severe life threatening infection -- would improve survival.
Researchers at the University of Sheffield and Boston's Children Hospital, Harvard Medical School have created a robot that can be implanted into the body to aid the treatment of oesophageal atresia, a rare birth defect that affects a baby's oesophagus.
Many drugs work by inhibiting protein enzymes associated with a particular disease. Unfortunately, the same drugs can inhibit protein enzymes unrelated to the disease, resulting in harmful side effects. Computational biologists have a way to identify the features that distinguish one enzyme from similar enzymes. This research has the potential to significantly accelerate drug discovery, allowing scientists to develop more effective drugs, more quickly.
Investigators at Case Western Reserve University School of Medicine and University Hospitals Cleveland Medical Center have developed a simple, swallowable test for early detection of Barrett's esophagus that offers promise for preventing deaths from esophageal adenocarcinoma.