New research from a randomised clinical trial published today in The Lancet and funded by the National Institute for Health Research (NIHR) shows that partial knee replacements (PKR) are as good as total knee replacements (TKR), whilst being more cost effective.
MSU researchers have found that many stroke patients feel unprepared when discharged from the hospital. Their caregivers feel the same. But when a home-based support network using social work case managers and online resources is put into place, quality of life and confidence in managing one's health improve, according to a new study published in the American Heart Association's journal Circulation: Cardiovascular Quality and Outcomes.
A promising vaccine that clears an HIV-like virus from monkeys is closer to human testing after a new, weakened version of the vaccine has been shown to provide similar protection as its original version. The vaccine -- which uses a form of the common herpes virus cytomegalovirus, or CMV -- was live-attenuated, or weakened so CMV couldn't spread as easily. Having an attenuated version of the vaccine is key to being potentially able to use it in humans.
In a review publishing July 17, 2019 in the journal Trends in Pharmacological Sciences, researchers examined how artificial intelligence (AI) could affect drug development in the coming decade.
Since the emergence of molecular genetics, scientists have tried to isolate haploid mammalian cells. Haploid cells are a powerful genetic tool to analyse gene function. In the past decade, a number of researchers finally succeeded in developing haploid cell line cultures. However, these cell lines are unstable and have a tendency for diploidisation. Now, researchers at the CNIO have identified chemical compounds that increase the stability of mammalian haploid cell lines.
Most people have probably been stung by a bee and while it can be painful, it's especially dangerous for those at risk of suffering a life threatening allergic reaction. Australian researchers have successfully completed a human trial on a vaccine designed to eliminate the risk of a severe allergic reaction to European honeybee stings.
Many people with HIV on antiretroviral therapy (ART) have viral genetic material in the cells of their cerebrospinal fluid, and these individuals are more likely to experience memory and concentration problems, according to a NIAID-funded study published in the Journal of Clinical Investigation. The findings suggest that HIV can persist in the nervous system even when the virus is suppressed in a patient's blood with medication.
HIV DNA remained in the cerebrospinal fluid of half of participants with well-managed HIV (virologic suppression in the plasma), confirming that the central nervous system (CNS) is a major reservoir for latent HIV. Individuals who harbored HIV DNA in the cerebrospinal fluid were more likely than other study participants to experience cognitive deficits on neurocognitive testing.
HIV-positive patients are living longer thanks to combination antiretroviral therapy (cART), but the virus can remain in some tissues, preventing a total cure. The results of a clinical study published this week in the JCI reveal that HIV can be detected in the central nervous system of patients treated with long-term cART. Its presence is associated with poorer cognitive performance, highlighting a need to address HIV's persistence in the brain and spinal cord.
Elevated blood pressure and cholesterol levels in young adulthood may lead to an increased risk of heart disease later in life, regardless of later in life exposure to these risk factors, according to research published today in the Journal of the American College of Cardiology.