A team of researchers has discovered that during development, when progenitor heart cells progressively differentiate into various cell types, the Hippo pathway is essential to coordinate the progress of these cell types into a working heart
A team led by Columbia University Biomedical Engineering Professor Gordana Vunjak-Novakovic has designed a creative new approach to help injured hearts regenerate by applying extracellular vesicles secreted by cardiomyocytes rather than implanting the cells. The study shows that the cardiomyocytes derived from human pluripotent stem cells (derived in turn from a small sample of blood) could be a powerful, untapped source of therapeutic microvesicles that could lead to safe and effective treatments of damaged hearts.
In the appropriate clinical setting, suspicion for acute aortic dissection should be raised when patients present with findings that have a high specificity and high positive likelihood ratio (hypotension, pulse deficit, or neurologic deficit).
Sickle cell trait may not be associated with the occurrence of ischemic stroke (when a blood clot blocks a blood vessel in the brain) in African-Americans, according to a meta-analysis that combined the results of four studies with 19,464 African-American participants.
Offering sigmoidoscopy screening to men and women in Norway reduced colorectal cancer (CRC) incidence and mortality in men, but had little or no effect in women. These findings suggest that current guidelines recommending that women get screened for CRC with flexible sigmoidoscopy should be reconsidered.
In a student-led study, one hour of mindfulness meditation shown to reduce anxiety and some cardiovascular risk markers.
An experimental compound appears to improve stroke outcome by reducing the destructive inflammation that can continue months after a stroke, scientists report. Rats consuming compound 21 following a clot-based stroke -- the most common type in humans -- don't have a smaller stroke size but do have better memory and movement in its aftermath, says Dr. Adviye Ergul, vascular physiologist and Regents' Professor in the Department of Physiology at the Medical College of Georgia at Augusta University.
Faster walking patients with heart disease are hospitalized less, according to research presented today at EuroPrevent 2018, a European Society of Cardiology congress, and published in the European Journal of Preventive Cardiology.
Belly fat, even in people who are not otherwise overweight, is bad for the heart, according to results from the Mayo Clinic presented today at EuroPrevent 2018, a European Society of Cardiology congress.
Scientists have re-created brain neurons of obese patients using 'disease in a dish' technology, offering a new method to study the brain's role in obesity and possibly help tailor treatments to specific individuals.