
Oncotarget: Identification intermediate-risk subgroups in metastatic clear-cell renal cell carcinoma
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"Elevated PLT count seems to identify a subgroup of patients with poor outcome in the IMDC intermediate-risk population with ccRCC"
"Suggesting that combined targeting of SLC6A14 and AMPK can be exploited as a therapeutic approach to starve tumor cells"
The @Oncotarget authors aimed to assess the effect of cirrhosis on outcomes in iCCA patients
The @Oncotarget authors show a drug class-effect with MEKi to stimulate NK cells, inhibit inflammatory cytokines and block host-factors for SARS-CoV-2 infection leading also to suppression of SARS-CoV-2-S pseudovirus infection of human cells
"The @Oncotarget authors demonstrate that MEK inhibitors are a promising targeted therapy for the basal subtype of bladder cancer, and their data indicate that drug screening of 3D cultures provides an important resource for hypothesis generation"
"The results suggest that this product, or similar fusion proteins featuring an N-terminal fusion in the diabody format, may deserve to be investigated in clinical trials"
Researchers from Rutgers Cancer Institute of New Jersey, the state's only National Cancer Institute-designated Comprehensive Cancer Center, evaluated the frequency of SARS-CoV-2, the virus that causes COVID-19, on various environmental surfaces in outpatient and inpatient hematology/oncology settings located within Rutgers Cancer Institute and Robert Wood Johnson University Hospital, an RWJBarnabas Health facility. The study revealed extremely low detection of SARS-CoV-2 on environmental surfaces across multiple outpatient and inpatient oncology areas, including an active COVID-19 floor.
A team of MedUni Vienna researchers led by Johannes A. Schmid at the Center for Physiology and Pharmacology, Institute of Vascular Biology and Thrombosis Research, has managed to identify a previously unknown molecular connection between an inflammatory signalling molecule and one of the main oncogenes. The study has been published in the leading journal 'Molecular Cancer'.
Oncotarget recently published "AKT isoforms have discrete expression in triple negative breast cancers and roles in cisplatin sensitivity" which reported that the authors investigated the expression and net effect of the individual isoforms in triple negative breast cancers and response to cisplatin treatment using cellular, mice models and clinical samples.
The aim of this Oncotarget review is to define the complex crosstalk between these two cell types and to highlight potential future anti-cancer strategies