In an analysis of how regulators review pesticides for their potential to cause cancer, researchers at Silent Spring Institute identified more than two dozen registered pesticides that were linked with mammary gland tumors in animal studies. The new findings raise concerns about how the US Environmental Protection Agency (EPA) approves pesticides for use and the role of certain pesticides in the development of breast cancer.
New study uses satellite images of outdoor lighting in Barcelona and Madrid.
A pair of recently published studies analyzed how ovarian function in mice responded to various levels of exposure to glyphosate, a chemical extensively used to kill weeds. The results showed exposure changed the level of some ovarian proteins but did not impact ovarian steroid production, an indication glyphosate may not adversely affect reproduction.
The cover for issue 29 of Oncotarget features Figure 5, "In vivo effects of treatment with L-Grb2 in combination with anti-angiogenic therapy in an ovarian tumor model," by Lara, et al. which reported that adaptor proteins such as growth factor receptor-bound protein-2 play important roles in cancer cell signaling. In the present study, the authors examined the biological effects of liposomal antisense oligodeoxynucleotide that blocks Grb2 expression in gynecologic cancer models.
Researchers used silicone wristbands to examine the extent of chemical exposure among a small group of children in Montevideo, Uruguay. The 6- to 8-year-olds wore the bands for seven days. After analyzing the wristbands, researchers found an average of 13 pollutants in each one collected. Some of the wristbands showed exposure to DDT, a harmful pesticide that has been banned for use in many countries, including the U.S., since the 1970s.
The cover for issue 28 of Oncotarget features Figure 5, 'TMEM165 expression levels alters N-linked glycosylation,' by Murali, et al., and reported that the TMEM165 protein was not detected in non-malignant matched breast tissues and was detected in invasive ductal breast carcinoma tissues by mass spectrometry.
Volume 11, Issue 28 of Oncotarget features 'Lipid and protein tumor markers for head and neck squamous cell carcinoma identified by imaging mass spectrometry' by Schmidt et, al. which reported that the authors used MALDI imaging mass spectrometry and immunohistochemistry to seek tumor-specific expression of proteins and lipids in HNSCC samples.
The discovery of the oncogene responsible for glioblastoma could be the brain cancer's Achilles' heel, one researcher says.
Human papilloma viruses (HPVs) - a common group of viruses known to cause cervical cancers - may also have a causal role in prostate cancer, according to a literature review published in the open access journal Infectious Agents and Cancer, supporting the case for universal HPV vaccination.
Lung cancer in non-smokers is a biologically distinct disease from that in smokers, according to a new study. Researchers also found that non-smokers have signs of genetic damage from environmental carcinogens and that some cancers look molecularly like more advanced disease - with characteristics that could be targeted with tailored treatments.