Offering open-access genetic testing for the inherited breast cancers BRCA1 and 2 to Ashkenazi women unaffected by cancer, regardless of their family history, enables the identification of carriers who would otherwise have been missed.
George Washington University researchers, published in the New England Journal of Medicine, find through looking at genetic data sets of presumed cancer-free women who carry BRCA 1/2 variants, the co-occurrence of a rare COMT genetic variant in some women. This research outlines a strategy for looking at large genetic data sets for clues as to why a genetic carrier may never develop the associated diseases.
A study from Fred Hutchinson Cancer Research Center that will be presented at the American Society of Clinical Oncology annual meeting on June 5 in Chicago shows that asymptomatic women who have been treated for early-stage breast cancer often undergo advanced imaging and other tests that provide little if any medical benefit, could have harmful effects and may increase their financial burden.
A Massachusetts General Hospital-based research team has identified a novel mechanism behind the resistance of breast cancer brain metastases to HER2- or PI3K-targeted therapies and a treatment strategy that may overcome this resistance.
A Clinical Breast Cancer study demonstrates Videssa Breast can inform better next steps after abnormal mammogram results and potentially reduce biopsies up to 67 percent.
A new report that analyzed the global scientific research on how diet, weight and exercise affect breast cancer risk finds there are steps women can take to lower their risk. The report finds that daily alcohol consumption and adult weight gain increase risk; physical activity and breastfeeding lower risk. The report also reveals, for the first time, that vigorous exercise decreases the risk of both pre- and post-menopausal breast cancers.
Researchers from Princeton University's Department of Molecular Biology have identified a small RNA molecule that helps maintain the activity of stem cells in both healthy and cancerous breast tissue. The study, which will be published in the June issue of Nature Cell Biology, suggests that this 'microRNA' promotes particularly deadly forms of breast cancer and that inhibiting the effects of this molecule could improve the efficacy of existing breast cancer therapies.
An American Cancer Society study of Medicare enrollees finds the risk for interval colorectal cancers, cancers that develop after a colonoscopy but before the next recommended test, is higher for blacks than whites.
In the May 22, 2017, issue of Developmental Cell, researchers at the Medical University of South Carolina Hollings Cancer Center developed a cross-species genetic screen in worms to follow cell-to-cell communication in human cancer. The genome-wide screen is being used to chart a roadmap between mesodermal cells and epithelial cells in the tumor microenvironment.
Lung cancer patients are particularly susceptible to malignant pleural effusion, when fluid collects in the space between the lungs and the chest wall. Researchers at the Helmholtz Zentrum München, in partnership with the German Center for Lung Research, have discovered a novel mechanism that causes this to happen. Their study, published in 'Nature Communications,' also shows that various active substances could potentially be used to treat this condition.