An increased proportion of Indigenous American (IA) ancestry was associated with a greater incidence of HER2-positive breast cancer, according to a study published in Cancer Research, a journal of the American Association for Cancer Research.
An analysis of a large Swedish cohort revealed that breast density, microcalcifications, and masses are heritable features, and that breast density and microcalcifications were positively associated with a genetic predisposition to breast cancer, according to a study published in Cancer Research, a journal of the American Association for Cancer Research.
They identified a protein that, like a switch, controls the onset of cell death processes in cancer cells, which are regulated by p53, the protein known as 'the guardian of the genome.' The findings will be used to develop more tailored and effective cancer treatments.
Researchers say they have found a viable new therapeutic strategy for estrogen receptor-positive (ER+) breast cancer, even cancers that are resistant to current standard of care treatments. They will present the results of their new preclinical study accepted for presentation at ENDO 2020, the Endocrine Society's annual meeting, and publication in a special supplemental section of the Journal of the Endocrine Society.
Researchers have developed the first blood test that can accurately detect more than 50 types of cancer and identify in which tissue the cancer originated, often before there are any signs of the disease. The test has a false positive rate of less than 1% meaning that less than 1% of people would be wrongly identified as having cancer. It can correctly predict the tissue in which the cancer originated in 93% of samples. The study is published in Annals of Oncology.
Nearly 200 radiologists who interpreted about 251,000 digital breast tomosynthesis (DBT) and 2 million digital mammography screening examinations were included in this observational study that evaluated recall and cancer detection rates.
Whether it is a drug-resistant strain of bacteria, or cancer cells that no longer react to the drugs intended to kill them, diverse mutations make cells resistant to chemicals, and 'second generation' approaches are needed. Now, a team of Penn State engineers may have a way to predict which mutations will occur in people, creating an easier path to create effective pharmaceuticals.
Researchers used a large commercial claims database to estimate the percentage of US women in their 40s with private insurance who were eligible and received screening mammography in 2017 and national costs for this screening.
Statins are widely used to lower cholesterol and prevent heart disease and related deaths, but can they also help guard against heart damage caused by certain breast cancer therapies? New research being presented at the American College of Cardiology's Annual Scientific Session Together with World Congress of Cardiology (ACC.20/WCC) suggests the answer may be yes.
The protein peptidyl arginine deiminase 4 (PAD4), which enables some immune cells to trap bacteria, promoted breast cancer metastasis in mice when expressed in cancer cells, according to data published in Molecular Cancer Research, a journal of the American Association for Cancer Research.