Offering $100 to patients eligible for a preventive colonoscopy screening more than doubled the rate of screening when compared to a simple emailed request, according to new research from the Perelman School of Medicine at the University of Pennsylvania.
In preclinical studies, tumors that consitutively expressed the protein indoleamine 2,3-dioxygenase (IDO1) responded to the cyclooxygenase-2 (COX-2) inhibitor celecoxib (Celebrex) and had improved infiltration of certain subsets of T cells, making them more likely to respond to anti-PD1 therapies.
A cooperative research team led by researchers at Dartmouth's Norris Cotton Cancer Center devised a strategy to target cancer cells while sparing normal cells by capitalizing on vulnerabilities that are exposed only in tumor cells. These vulnerabilities are known as the 'Achilles heel' of cancer cells. Although much is known about the mutations that cause a cell to become malignant, little is known about these vulnerabilities. The team has published new findings on this topic.
Fewer Australian teenagers are drinking alcohol but more needs to be done to curb the drinking habits of Aussie students, based on the findings of the latest study by Adelaide researchers.
Scientists may be able to minimize the failure rate of drugs for diseases linked to high-calorie diets, such as colon cancer and type 2 diabetes, if they test treatments using a pig model, according to an international team of researchers.
New research provides insight into how changes that occur with age may predispose breast tissue cells to becoming cancerous. Specifically, the study demonstrates that regions in the genome where DNA methylation changes occur with age are particularly sensitive to disruption in cancer. This new data provides insight into how certain molecular changes with age in normal breast tissue itself may contribute to breast cancer risk.
Cancer survivors often talk about wanting to get back to normal, but a new study indicates many young adults who survived the disease struggle with attaining this goal two years after their initial diagnosis.
For patients with advanced, inoperable stage 3 lung cancer, concurrent chemotherapy and the specialized radiation treatment, proton therapy, offers improved survival compared to historical data for standard of care, according to a new study from The University of Texas MD Anderson Cancer Center.
The presence of a germline mutation in the GOT2 gene found in a patient with metastasis gives rise to increased activity of the encoder enzyme. Furthermore, the authors describe extraordinarily rare mutations in two patients: one in the SDHC gene and another in the IDH1. Finally, by way of an extension study focused on more than 60 patients with these neuroendocrine tumors, a new susceptibility gene, IDH3B, associated with the development of paragangliomas was identified.
Whether a melanoma patient will better respond to a single immunotherapy drug or two in combination depends on the abundance of certain white blood cells within their tumors, according to a new study conducted by UC San Francisco researchers joined by physicians from UCSF Health.