A genetic variant found only in people of African descent significantly increases a smoker's preference for cigarettes containing menthol, a flavor additive. The variant of the MRGPRX4 gene is five to eight times more frequent among smokers who use menthol cigarettes than other smokers. The multi-ethnic study is the first to look across all genes to identify genetic vulnerability to menthol cigarettes.
- PLOS Genetics
- Family Smoking Prevention and Tobacco Control Act, NIH/National Institute on Deafness and Communication Disorders, NIH/National Center for Advancing Translational Sciences, NIH/National Institute of Mental Health