Brazilian researchers show that a combination of inflammatory cytokines in the blood and cannabis use, daily or during adolescence, heightens the odds of developing psychiatric disorders.
A UCLA clinical trial has shown encouraging results in helping daily smokers who are also heavy drinkers quit smoking and reduce their alcohol intake.
A discovery from researchers at the University of Illinois Chicago may lead to new treatments for individuals who suffer from alcohol use disorder and depression.
Nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen provide better pain control and have fewer adverse effects than codeine, a commonly prescribed opioid, when prescribed after outpatient surgery, according to new research published in CMAJ (Canadian Medical Association Journal).
Prevalence rates of opioid use disorder (OUD) have increased dramatically, accompanied by a surge of overdose deaths--nearly 50,000 in the U.S. in 2019. While opioid dependence has been extensively studied in preclinical models, an understanding of the biological alterations that occur in the brains of people who chronically use opioids and who are diagnosed with OUD remains limited.
Lab animals deficient in vitamin D crave and become dependent on opioids, which is curbed when normal levels of the vitamin are restored. Human health records indicate that people with low vitamin D are more likely to use and misuse opioids. Study results suggest a potential role for vitamin D supplementation in fighting opioid addiction.
Surgeons can ease their patients' pain from common operations without prescribing opioids, and avoid the possibility of starting someone on a path to long-term use, a pair of new studies suggests.
Researchers at UC San Diego, San Diego State University, and international collaborators have designed and validated a prediction model to signal counties at risk of future overdose death outbreaks.
New research published online in the journal Substance Use & Misuse is good news for those struggling with alcohol dependence: the possibility of ending this dependency gets easier with age. Moreover, more than half of individuals who have been dependent on alcohol are free of any addictions or mental illness, and nearly 40% are in excellent mental health.