Research from the Monell Center documented wide individual differences to the taste of the life-saving HIV medication Kaletra and identified genetic sources of the taste variation. The findings suggest that the growing field of pharmacogenetics should assess the sensory response to medicines to promote medication compliance and treatment success.
If just a quarter of high-risk men who have sex with men were to use daily preventive medicine, the United States could surpass its goal of reducing new HIV infections by 25 percent.
A KAIST research team of Professor Hyun Gyu Park at Department of Chemical and Biomolecular Engineering developed a new technology to detect the activity of RNase H, a RNA degrading enzyme. The team used highly efficient signal amplification reaction termed catalytic hairpin assembly (CHA) to effectively analyze the RNase H activity. Considering that RNase H is required in the proliferation of retroviruses such as HIV, this research finding could contribute to AIDS treatments in the future, researchers say.
A chemical found in marijuana, known as tetrahydrocannabinol, or THC, has been found to potentially slow the process in which mental decline can occur in up to 50 percent of HIV patients, says a new Michigan State University study.
HIV-1 regulation by the HLA-B*52:01 allele has been established for some time. However, evidence of regulation by its companion, the HLA-C*12:02 allele, has been difficult to produce due to the strong linkage. Researchers from the Center for AIDS research in Kumamoto University, Japan have produced the first evidence of HLA-C's control of HIV-1, but they note that it comes with a price. Namely, the possibility of a different autoimmune disease.
Almost half of combination antiretroviral therapy (cART)-treated HIV patients experience some degree of neurocognitive impairment (neuroHIV). To search for underlying pathology, scientists analyzed the brains of monkeys infected with simian immunodeficiency virus (SIV) then treated with cART. As reported in a new study in The American Journal of Pathology, the majority of the SIV-infected macaque brains showed signs of unusual lymphocyte-dominant inflammation, suggesting that persistent neuroinflammation may underlie cognitive problems in cART-treated HIV patients.
A new study has shown that HIV-infected women do not use statins as recommended by the most recent guidelines.
This is the first time that both Cryptococcus neoformans and Cryptococcus gattii have been found in such large numbers on trees in South Africa. To date, only two studies (one from 2009 and the other published in 2011) have reported the presence of these pathogens in the South African environment.
A recent study from North Carolina State University and the University of North Carolina at Chapel Hill finds that a 45-minute online sexual health program improved the ability of teen girls to communicate effectively about safe sex.
A randomized, double-blind, placebo-controlled clinical trial found no benefit for a therapeutic HIV vaccine, but could offer researchers much needed insights for future cure efforts.