A new study by Scripps Research, published today in Nature Communications, suggests scientists could build better drugs by learning from bacteria-derived molecules called thiocarboxylic acids.
An algorithm to monitor the joints of patients with arthritis, which could change the way that the severity of the condition is assessed, has been developed by a team of engineers, physicians and radiologists led by the University of Cambridge.
Constructing biological tissues, such as skin, muscle, or bone, in customized shapes is now one step closer. Researchers at EMBL have succeeded in guiding the folding and thus shape of tissues with optogenetics: a technique to control protein activity with light. Nature Communications publishes their results, with implications for regenerative medicine, on June 18.
In a study in The American Journal of Pathology, investigators report that treatment with aleglitazar, a dual peroxisome proliferator-activated receptor-alpha/gamma (PPARα/γ) agonist, reduced inflammation, vasoconstriction, angiogenesis, mucosal disruption, and tumor necrosis factor (TNF)-α overproduction in cirrhotic rats with PH. This suggests a promising new approach for treating liver cirrhosis.
A diverse mix of species improves the stability and fuel-oil yield of algal biofuel systems, as well as their resistance to invasion by outsiders, according to the findings of a federally funded outdoor study by University of Michigan researchers.
The PIM-2 protein kinase negatively regulates T cell responses in transplantation and tumor immunity, while PIM-1 and PIM-3 are positive regulators, report Medical University of South Carolina investigators in The Journal of Clinical Investigation. Blocking PIM-2 in allogeneic bone marrow transplant dramatically accelerated graft-versus-host disease. In adoptive immunotherapy with autologous T cells, silencing PIM-2 on T cells produced robust tumor immunity, highlighting the importance of PIM-specific inhibition.
It has been previously reported that the tunic of Halocynthia roretzi, mainly composed of cellulose, is actively deformed with mass transfer by the mechanical stimuli. In this study, how the tunic deforms in response to the mechanical environment was investigated.
Purdue University researchers have identified a new compound that in preliminary testing has shown itself to be as effective as antibiotics approved by the FDA to treat life-threatening infections while also appearing to be less susceptible to bacterial resistance. The compound has been potent against antibiotic-resistant pathogens such as MRSA, which is often found in hospitals and other health care settings, and vancomycin-resistant Staphylococcus, with vancomycin long considered a drug of last resort.
An international team of scientists, including NUST MISIS's Professor Gotthard Seifert, have made an important step towards the control of excitonic effects in two-dimensional van der Waals heterostructures. In the future, this research will help to create electronics with more controlled properties. The research has been published in Nature Physics.
An international team of scientists have predicted a new superhard material that can be used in drilling, machine building and other fields. The new tungsten boride they discovered outperforms the widely used 'pobedit' ? a hard tungsten carbide and cobalt composite material with artificial diamond interspersing.